SAMD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAMD8_HUMAN
• UniProt AC: Q96LT4
• Protein Name: Sphingomyelin synthase-related protein 1
• Gene Name: SAMD8
• Organism: Homo sapiens (Human).
• Sequence Length: 415
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway..
• Protein Sequence: MAGPNQLCIRRWTTKHVAVWLKDEGFFEYVDILCNKHRLDGITLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKIHIDVLEEMGYNSDSPMGSMTPFISALQSTDWLCNGELSHDCDGPITDLNSDQYQYMNGKNKHSVRRLDPEYWKTILSCIYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFAMTEVCGMILCYIWLLVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKIYGSVWEKLHRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYQQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	QLCIRRWTTKHVAVW CEEEECCCCCEEEEE	24.93	22798277
60	Ubiquitination	RSPPLEIKVLGDIKR CCCCEEEEEHHHHHH	23.25	2190698
66	Ubiquitination	IKVLGDIKRLMLSVR EEEHHHHHHHHHHHH	44.19	-
123	Ubiquitination	SHDCDGPITDLNSDQ CCCCCCCCCCCCCHH	5.98	21906983
183	Phosphorylation	RVPDMQTYPPLPDIF CCCCCCCCCCCCCCC	5.98	-
193	Phosphorylation	LPDIFLDSVPRIPWA CCCCCCCCCCCCCHH	35.85	21815630
234	Phosphorylation	ILLRRLCSLMGTVFL HHHHHHHHHHHHHHH	26.44	-
238	Phosphorylation	RLCSLMGTVFLLRCF HHHHHHHHHHHHHHH	8.30	-
246	Phosphorylation	VFLLRCFTMFVTSLS HHHHHHHHHHHHHCC	17.21	29083192
250	Phosphorylation	RCFTMFVTSLSVPGQ HHHHHHHHHCCCCCC	16.82	29083192
251	Phosphorylation	CFTMFVTSLSVPGQH HHHHHHHHCCCCCCC	17.22	29083192
253	Phosphorylation	TMFVTSLSVPGQHLQ HHHHHHCCCCCCCEE	26.49	29083192
262	Phosphorylation	PGQHLQCTGKIYGSV CCCCEEECCEEEHHH	28.66	29083192
362	Phosphorylation	ITTRLFLYYHTLANT HHHHHHHHHHHHHCC	5.95	29759185
363	Phosphorylation	TTRLFLYYHTLANTR HHHHHHHHHHHHCCH	7.17	24260401
365	Phosphorylation	RLFLYYHTLANTRAY HHHHHHHHHHCCHHH	16.08	29759185
369	Phosphorylation	YYHTLANTRAYQQSR HHHHHHCCHHHHHHH	15.86	24260401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAMD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAMD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAMD8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SAMD8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.