PAQR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAQR2_HUMAN
• UniProt AC: Q86V24
• Protein Name: Adiponectin receptor protein 2 {ECO:0000303|PubMed:25969726}
• Gene Name: ADIPOR2 {ECO:0000312|HGNC:HGNC:24041}
• Organism: Homo sapiens (Human).
• Sequence Length: 386
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Localized to the cell membrane and intracellular organelles.
• Protein Description: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. [PubMed: 12802337]
• Protein Sequence: MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKSSEEHEYSDEAPQEDEGFMGMSPLLQAHHAMEKMEEFVCKVWEGRWRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYVISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCSEEDAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	TENRLGCSRTPEPDI CCCCCCCCCCCCCCC		23312004
14	Phosphorylation	NRLGCSRTPEPDIRL CCCCCCCCCCCCCEE		21815630
23	Ubiquitination	EPDIRLRKGHQLDGT CCCCEECCCCCCCCC		29967540
53	Phosphorylation	LEASVLSSHHKKSSE HHHHHHHHCCCCCCC		28555341
56	Ubiquitination	SVLSSHHKKSSEEHE HHHHHCCCCCCCCCC		29967540
58	Phosphorylation	LSSHHKKSSEEHEYS HHHCCCCCCCCCCCC		26471730
59	Phosphorylation	SSHHKKSSEEHEYSD HHCCCCCCCCCCCCC		26471730
64	Phosphorylation	KSSEEHEYSDEAPQE CCCCCCCCCCCCCCC		26471730
65	Phosphorylation	SSEEHEYSDEAPQED CCCCCCCCCCCCCCC		26471730
79	Phosphorylation	DEGFMGMSPLLQAHH CCCCCCHHHHHHHHH		28555341
90	Ubiquitination	QAHHAMEKMEEFVCK HHHHHHHHHHHHHHH		29967540
97	Ubiquitination	KMEEFVCKVWEGRWR HHHHHHHHHHCCCCE		21963094
116	Ubiquitination	DVLPDWLKDNDFLLH HCCCHHHHCCCEECC		-
137	Ubiquitination	PSFRACFKSIFRIHT HHHHHHHHHHHHHHC		21963094
216	Phosphorylation	EGVSRLFSKLDYSGI HHHHHHHHCCCCCHH		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAQR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAQR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAQR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DP13A_HUMAN	APPL1	physical	16622416
NCK1_HUMAN	NCK1	physical	26186194
RN181_HUMAN	RNF181	physical	26186194
RN181_HUMAN	RNF181	physical	28514442
NCK1_HUMAN	NCK1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.