HM13_HUMAN - dbPTM
HM13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HM13_HUMAN
UniProt AC Q8TCT9
Protein Name Minor histocompatibility antigen H13
Gene Name HM13
Organism Homo sapiens (Human).
Sequence Length 377
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Membrane
Multi-pass membrane protein
Lumenal side .
Isoform 4: Cell membrane
Multi-pass membrane protein .
Protein Description Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. [PubMed: 11714810 May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein]
Protein Sequence MDSALSDPHNGSAEAGGPTNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARGKNASDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVTEMFSYEESNPKDPAAVTESKEGTEASASKGLEKKEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10N-linked_GlycosylationSALSDPHNGSAEAGG
CCCCCCCCCCCCCCC		52.0512077416
10N-linked_GlycosylationSALSDPHNGSAEAGG
CCCCCCCCCCCCCCC		52.0512077416
12PhosphorylationLSDPHNGSAEAGGPT
CCCCCCCCCCCCCCC		28.4020860994
20N-linked_GlycosylationAEAGGPTNSTTRPPS
CCCCCCCCCCCCCCC		40.2612077416
20N-linked_GlycosylationAEAGGPTNSTTRPPS
CCCCCCCCCCCCCCC		40.2612077416
61 (in isoform 2)Ubiquitination-43.7321890473
61MalonylationSVRCARGKNASDMPE
HHHHHCCCCHHHCCC		43.7326320211
61UbiquitinationSVRCARGKNASDMPE
HHHHHCCCCHHHCCC		43.7321906983
61 (in isoform 5)Ubiquitination-43.7321890473
61 (in isoform 4)Ubiquitination-43.7321890473
61 (in isoform 1)Ubiquitination-43.7321890473
64PhosphorylationCARGKNASDMPETIT
HHCCCCHHHCCCCCC		43.7821712546
66SulfoxidationRGKNASDMPETITSR
CCCCHHHCCCCCCHH		2.7521406390
69PhosphorylationNASDMPETITSRDAA
CHHHCCCCCCHHHHH		24.5527732954
71PhosphorylationSDMPETITSRDAARF
HHCCCCCCHHHHHHC		25.7327732954
72PhosphorylationDMPETITSRDAARFP
HCCCCCCHHHHHHCH		25.0627732954
90PhosphorylationSCTLLGLYLFFKIFS
HHHHHHHHHHHHHHC		10.32-
138PhosphorylationASFPNRQYQLLFTQG
CCCCCCEEEEEEECC		9.63-
150 (in isoform 1)Ubiquitination-53.0421890473
150 (in isoform 4)Ubiquitination-53.0421890473
150 (in isoform 2)Ubiquitination-53.0421890473
150 (in isoform 5)Ubiquitination-53.0421890473
150UbiquitinationTQGSGENKEEIINYE
ECCCCCCHHHEEEEE		53.0421906983
156PhosphorylationNKEEIINYEFDTKDL
CHHHEEEEECCCCCC		13.94-
199 (in isoform 5)Ubiquitination-3.2021890473
241 (in isoform 2)Ubiquitination-37.2221890473
241UbiquitinationKSFEAPIKLVFPQDL
HHCCCCEEEECCHHH		37.2220639865
241 (in isoform 4)Ubiquitination-37.2221890473
241 (in isoform 1)Ubiquitination-37.2221890473
241UbiquitinationKSFEAPIKLVFPQDL
HHCCCCEEEECCHHH		37.2221890473
242 (in isoform 5)Ubiquitination-5.0621890473
284UbiquitinationLRFDISLKKNTHTYF
HHCCEECCCCCCCCC		36.8721906983
284 (in isoform 4)Ubiquitination-36.8721890473
284 (in isoform 2)Ubiquitination-36.8721890473
284 (in isoform 1)Ubiquitination-36.8721890473
310 (in isoform 5)Ubiquitination-19.9521890473
319 (in isoform 5)Ubiquitination-4.0421890473
328 (in isoform 5)Ubiquitination-22.2321890473
341PhosphorylationALAKGEVTEMFSYEE
HHHCCCEEECEECCC		19.8920860994
343SulfoxidationAKGEVTEMFSYEESN
HCCCEEECEECCCCC		1.6528465586
345PhosphorylationGEVTEMFSYEESNPK
CCEEECEECCCCCCC		30.2620860994
346PhosphorylationEVTEMFSYEESNPKD
CEEECEECCCCCCCC		16.6727642862
352 (in isoform 1)Ubiquitination-79.2721890473
352AcetylationSYEESNPKDPAAVTE
ECCCCCCCCCCCCCC		79.2726051181
352UbiquitinationSYEESNPKDPAAVTE
ECCCCCCCCCCCCCC		79.2721906983
356 (in isoform 2)Phosphorylation-17.7224719451
356 (in isoform 4)Phosphorylation-17.7224719451
358PhosphorylationPKDPAAVTESKEGTE
CCCCCCCCCCCCCCH		29.7920068231
360PhosphorylationDPAAVTESKEGTEAS
CCCCCCCCCCCCHHH		27.0020068231
360 (in isoform 2)Phosphorylation-27.0028450419
360 (in isoform 4)Phosphorylation-27.0028450419
361 (in isoform 1)Ubiquitination-54.6621890473
361UbiquitinationPAAVTESKEGTEASA
CCCCCCCCCCCHHHH		54.6621906983
364 (in isoform 2)Phosphorylation-29.4830266825
364 (in isoform 4)Phosphorylation-29.4830266825
364PhosphorylationVTESKEGTEASASKG
CCCCCCCCHHHHHCC		29.4828857561
366 (in isoform 2)Phosphorylation-15.3830266825
366 (in isoform 4)Phosphorylation-15.3830266825
367PhosphorylationSKEGTEASASKGLEK
CCCCCHHHHHCCCCC		27.1812077416
368 (in isoform 4)Phosphorylation-23.4730266825
368 (in isoform 2)Phosphorylation-23.4730266825
369PhosphorylationEGTEASASKGLEKKE
CCCHHHHHCCCCCCC		25.4323312004
370 (in isoform 1)Ubiquitination-68.2021890473
370UbiquitinationGTEASASKGLEKKEK
CCHHHHHCCCCCCCC		68.202190698
371 (in isoform 4)Phosphorylation-36.2530266825
371 (in isoform 2)Phosphorylation-36.2530266825
375 (in isoform 2)Phosphorylation-62.4528450419
375 (in isoform 4)Phosphorylation-62.4528450419
392 (in isoform 2)Phosphorylation-28796482
395 (in isoform 2)Phosphorylation-28796482
410 (in isoform 2)Ubiquitination-21890473
419 (in isoform 2)Ubiquitination-21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HM13_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HM13_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HM13_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSRA_HUMANSSR1physical
22939629
DERL1_HUMANDERL1physical
25239945
RN139_HUMANRNF139physical
25239945
XBP1_HUMANXBP1physical
25239945
LZTS2_HUMANLZTS2physical
25416956
AT2B1_HUMANATP2B1physical
26344197
AT2B3_HUMANATP2B3physical
26344197
AT2B4_HUMANATP2B4physical
26344197
STOM_HUMANSTOMphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HM13_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-10 AND ASN-20, AND MASSSPECTROMETRY.

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