NRAM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRAM2_HUMAN
• UniProt AC: P49281
• Protein Name: Natural resistance-associated macrophage protein 2
• Gene Name: SLC11A2
• Organism: Homo sapiens (Human).
• Sequence Length: 568
• Subcellular Localization: Isoform 2: Cell membrane ; Multi-pass membrane protein . Early endosome .; Endosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Also found in extra
• Protein Description: Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria..
• Protein Sequence: MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LGPEQKMSDDSVSGD CCCCCCCCCCCCCCC	45.35	26074081
13	Phosphorylation	EQKMSDDSVSGDHGE CCCCCCCCCCCCCCC	24.15	26074081
15	Phosphorylation	KMSDDSVSGDHGESA CCCCCCCCCCCCCCC	42.32	26074081
18 (in isoform 4)	Phosphorylation	-	45.50	24719451
18 (in isoform 3)	Phosphorylation	-	45.50	24719451
21	Phosphorylation	VSGDHGESASLGNIN CCCCCCCCCCCCCCC	27.96	26074081
23	Phosphorylation	GDHGESASLGNINPA CCCCCCCCCCCCCCC	46.20	26074081
23 (in isoform 4)	Phosphorylation	-	46.20	28348404
23 (in isoform 3)	Phosphorylation	-	46.20	28348404
25 (in isoform 4)	Phosphorylation	-	30.40	28348404
25 (in isoform 3)	Phosphorylation	-	30.40	28348404
28 (in isoform 4)	Phosphorylation	-	21.10	28348404
28 (in isoform 3)	Phosphorylation	-	21.10	28348404
29 (in isoform 4)	Phosphorylation	-	28.86	28348404
29 (in isoform 3)	Phosphorylation	-	28.86	28348404
31	Phosphorylation	LGNINPAYSNPSLSQ CCCCCCCCCCCCHHC	15.39	27251275
32	Phosphorylation	GNINPAYSNPSLSQS CCCCCCCCCCCHHCC	44.35	29802988
35	Phosphorylation	NPAYSNPSLSQSPGD CCCCCCCCHHCCCCC	44.92	28348404
37	Phosphorylation	AYSNPSLSQSPGDSE CCCCCCHHCCCCCCH	32.71	27251275
39	Phosphorylation	SNPSLSQSPGDSEEY CCCCHHCCCCCCHHH	27.72	28348404
43	Phosphorylation	LSQSPGDSEEYFATY HHCCCCCCHHHHHHH	37.94	28348404
46	Phosphorylation	SPGDSEEYFATYFNE CCCCCHHHHHHHHCC	8.41	28348404
56	Phosphorylation	TYFNEKISIPEEEYS HHHCCCCCCCHHHHC	43.06	29507054
64	S-palmitoylation	IPEEEYSCFSFRKLW CCHHHHCCCHHHHHH	3.03	29575903
66	Phosphorylation	EEEYSCFSFRKLWAF HHHHCCCHHHHHHHH	28.59	24719451
81	Phosphorylation	TGPGFLMSIAYLDPG HCCCEEEEEEECCCC	13.25	23663014
84	Phosphorylation	GFLMSIAYLDPGNIE CEEEEEEECCCCCCC	15.23	23663014
129	Phosphorylation	AARLGVVTGLHLAEV HHHHCCHHHHHHHHH	31.45	-
176	Phosphorylation	AIAINLLSVGRIPLW HHHHHHHCCCCCCCC	26.20	-
250	Phosphorylation	PSCSGCRTPQIEQAV CCCCCCCCHHHHHHH	24.50	-
273	Phosphorylation	PHNMYLHSALVKSRQ CCHHHHHHHHHHHHC	22.24	-
336	N-linked_Glycosylation	QVVEVCTNTSSPHAG CEEEHHCCCCCCCCC	32.60	UniProtKB CARBOHYD
349	N-linked_Glycosylation	AGLFPKDNSTLAVDI CCCCCCCCCEEEEEE	42.91	UniProtKB CARBOHYD
536	Phosphorylation	CLIALGMSFLDCGHT HHHHHHCHHHCCCCC	22.36	-
555 (in isoform 5)	Phosphorylation	-	13.89	-
559 (in isoform 2)	Phosphorylation	-	19.19	-
564	Phosphorylation	LNTMDADSLVSR--- EECCCHHHHHCC---	32.18	25137130
567	Phosphorylation	MDADSLVSR------ CCHHHHHCC------	37.25	25137130
588 (in isoform 3)	Phosphorylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	WWP2	O00308	PMID:18776082
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:19706893

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRAM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRAM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFIP1_HUMAN	NDFIP1	physical	18776082
NFIP2_HUMAN	NDFIP2	physical	18776082
PRKN_HUMAN	PARK2	physical	20089134
NFIP1_HUMAN	NDFIP1	physical	19706893
NEDD4_HUMAN	NEDD4	physical	19706893

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.