RER1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RER1_HUMAN
• UniProt AC: O15258
• Protein Name: Protein RER1
• Gene Name: RER1
• Organism: Homo sapiens (Human).
• Sequence Length: 196
• Subcellular Localization: Golgi apparatus membrane; Multi-pass membrane protein.
• Protein Description: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment..
• Protein Sequence: MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEGDSVGE ------CCCCCCCCC	50.73	29255136
2	Acetylation	------MSEGDSVGE ------CCCCCCCCC	50.73	20068231
6	Phosphorylation	--MSEGDSVGESVHG --CCCCCCCCCCCCC	42.76	22167270
10	Phosphorylation	EGDSVGESVHGKPSV CCCCCCCCCCCCHHH	17.31	22167270
14	Malonylation	VGESVHGKPSVVYRF CCCCCCCCHHHHHHH	21.17	26320211
14	Ubiquitination	VGESVHGKPSVVYRF CCCCCCCCHHHHHHH	21.17	21890473
16	Phosphorylation	ESVHGKPSVVYRFFT CCCCCCHHHHHHHHH	27.92	29396449
19	Phosphorylation	HGKPSVVYRFFTRLG CCCHHHHHHHHHHHH	10.27	29396449
35	Ubiquitination	IYQSWLDKSTPYTAV HHHHHHCCCCCCHHH	54.80	21906983
54	Phosphorylation	TLGLSFVYMIRVYLL HHHHHHHHHHHHHHH	5.70	-
59	Phosphorylation	FVYMIRVYLLQGWYI HHHHHHHHHHCHHHH	7.58	-
84	Phosphorylation	NLFIAFLSPKVDPSL HHHHHHHCCCCCHHH	19.07	-
90	Phosphorylation	LSPKVDPSLMEDSDD HCCCCCHHHCCCCCC	35.57	30266825
92	Sulfoxidation	PKVDPSLMEDSDDGP CCCCHHHCCCCCCCC	6.71	21406390
95	Phosphorylation	DPSLMEDSDDGPSLP CHHHCCCCCCCCCCC	25.05	29255136
100	Phosphorylation	EDSDDGPSLPTKQNE CCCCCCCCCCCCCCH	53.13	30266825
103	Phosphorylation	DDGPSLPTKQNEEFR CCCCCCCCCCCHHCH	51.02	23927012
171	Ubiquitination	RQIKHMIKYRYIPFT HHHHHHHHHCCCCCC	18.99	-
174	Phosphorylation	KHMIKYRYIPFTHGK HHHHHHCCCCCCCCC	15.17	28152594
181	Ubiquitination	YIPFTHGKRRYRGKE CCCCCCCCCCCCCCC	26.54	21890473
192	Ubiquitination	RGKEDAGKAFAS--- CCCCCCHHHCCC---	41.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RER1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RER1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RER1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIC60_HUMAN	IMMT	physical	16169070
HAP1_HUMAN	HAP1	physical	16169070
SH3G3_HUMAN	SH3GL3	physical	16169070
PMP22_HUMAN	PMP22	physical	25385046
STX12_HUMAN	STX12	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-95, AND MASSSPECTROMETRY.
PubMed: 18691976