PMP22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMP22_HUMAN
• UniProt AC: Q01453
• Protein Name: Peripheral myelin protein 22
• Gene Name: PMP22
• Organism: Homo sapiens (Human).
• Sequence Length: 160
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Might be involved in growth regulation, and in myelinization in the peripheral nervous system..
• Protein Sequence: MLLLLLSIIVLHVAVLVLLFVSTIVSQWIVGNGHATDLWQNCSTSSSGNVHHCFSSSPNEWLQSVQATMILSIIFSILSLFLFFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYTVRHPEWHLNSDYSYGFAYILAWVAFPLALLSGVIYVILRKRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	HATDLWQNCSTSSSG CCCCHHHHCCCCCCC	15.32	10982389
41	N-linked_Glycosylation	HATDLWQNCSTSSSG CCCCHHHHCCCCCCC	15.32	10982389
85	S-palmitoylation	LSLFLFFCQLFTLTK HHHHHHHHHHHHCCC	2.42	29575903
99	Phosphorylation	KGGRFYITGIFQILA CCCEEEHHHHHHHHH	16.91	24719451
117	Phosphorylation	VMSAAAIYTVRHPEW HHHHHHHHHCCCCHH	8.41	24719451
118	Phosphorylation	MSAAAIYTVRHPEWH HHHHHHHHCCCCHHH	12.63	24719451
153	Phosphorylation	ALLSGVIYVILRKRE HHHHHCHHHHHHCCC	4.50	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMP22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMP22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMP22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYP0_HUMAN	MPZ	physical	10212299
SMIM3_HUMAN	SMIM3	physical	25416956
SYVN1_HUMAN	SYVN1	physical	25385046
AMFR_HUMAN	AMFR	physical	25385046
RER1_HUMAN	RER1	physical	25385046
CALX_HUMAN	CANX	physical	25385046

Drug and Disease Associations

• Kegg Disease
• H00264: Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atroph
• H01296: Hereditary neuropathy with liability to pressure palsies (HNPP)
• OMIM Disease
• 118220: Charcot-Marie-Tooth disease 1A (CMT1A)
• 145900: Dejerine-Sottas syndrome (DSS)
• 162500: Hereditary neuropathy with liability to pressure palsies (HNPP)
• 118300: Charcot-Marie-Tooth disease 1E (CMT1E)
• 139393: Inflammatory demyelinating polyneuropathy (IDP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.