MYP0_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYP0_HUMAN
• UniProt AC: P25189
• Protein Name: Myelin protein P0
• Gene Name: MPZ
• Organism: Homo sapiens (Human).
• Sequence Length: 248
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein.; Isoform L-MPZ: Myelin membrane ; Single-pass type I membrane protein .
• Protein Description: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction..
• Protein Sequence: MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	EGGRDAISIFHYAKG CCCCEEEEEEEHHCC	22.41	24719451
82	Phosphorylation	DAISIFHYAKGQPYI EEEEEEEHHCCCCCC	10.16	24719451
122	N-linked_Glycosylation	HNLDYSDNGTFTCDV EECCCCCCCEEEEEC	45.52	UniProtKB CARBOHYD
139	Phosphorylation	PPDIVGKTSQVTLYV CCCCCCEECEEEEEE	20.61	-
154	Phosphorylation	FEKVPTRYGVVLGAV EEECCCCHHHHHHHH	19.42	-
177	Phosphorylation	LLLLLLFYVVRYCWL HHHHHHHHHHHHHHH	9.67	-
181	Phosphorylation	LLFYVVRYCWLRRQA HHHHHHHHHHHHHHH	4.03	-
195	Phosphorylation	AALQRRLSAMEKGKL HHHHHHHHHHHCCCC	24.61	26657352
210	Phosphorylation	HKPGKDASKRGRQTP CCCCCCHHHHCCCCH	32.78	7530295
216	Phosphorylation	ASKRGRQTPVLYAML HHHHCCCCHHHHHHC	17.63	23911959
220	Phosphorylation	GRQTPVLYAMLDHSR CCCCHHHHHHCCCCC	7.09	7530295
226	Phosphorylation	LYAMLDHSRSTKAVS HHHHCCCCCCCHHHH	27.82	7530295
228	Phosphorylation	AMLDHSRSTKAVSEK HHCCCCCCCHHHHHH	36.96	7530295
233	Phosphorylation	SRSTKAVSEKKAKGL CCCCHHHHHHHHCCC	48.86	7530295
243	Phosphorylation	KAKGLGESRKDKK-- HHCCCCCCCCCCC--	42.71	7530295
263 (in isoform 2)	Phosphorylation	-		29507054

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
210	S	Phosphorylation	Kinase	PKC	-	Uniprot
233	S	Phosphorylation	Kinase	PKC	-	Uniprot
243	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYP0_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYP0_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PMP22_HUMAN	PMP22	physical	10212299
PSB3_HUMAN	PSMB3	physical	21988832

Drug and Disease Associations

• Kegg Disease
• H00264: Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atroph
• H01155: Roussy-Levy syndrome
• OMIM Disease
• 118200: Charcot-Marie-Tooth disease 1B (CMT1B)
• 607677: Charcot-Marie-Tooth disease 2I (CMT2I)
• 607736: Charcot-Marie-Tooth disease 2J (CMT2J)
• 103100: Adie pupil (ADIEP)
• 607791: Charcot-Marie-Tooth disease, dominant, intermediate type, D (CMTDID)
• 145900: Dejerine-Sottas syndrome (DSS)
• 605253: Neuropathy, congenital hypomyelinating or amyelinating (CHN)
• 180800: Roussy-Levy syndrome (ROULS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.