S12A2_HUMAN - dbPTM
S12A2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S12A2_HUMAN
UniProt AC P55011
Protein Name Solute carrier family 12 member 2
Gene Name SLC12A2
Organism Homo sapiens (Human).
Sequence Length 1212
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume..
Protein Sequence MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEPRPTAP
-------CCCCCCCC		57.9222223895
9PhosphorylationEPRPTAPSSGAPGLA
CCCCCCCCCCCCCCC		38.6522210691
21PhosphorylationGLAGVGETPSAAALA
CCCCCCCCHHHHHHH		19.3327050516
23PhosphorylationAGVGETPSAAALAAA
CCCCCCHHHHHHHHH		37.6529496963
41PhosphorylationLPGTAVPSVPEDAAP
CCCCCCCCCCCCCCC		43.6428348404
50PhosphorylationPEDAAPASRDGGGVR
CCCCCCCCCCCCCCC		29.8222210691
75PhosphorylationLGRPLGPTPSQSRFQ
CCCCCCCCCCCCCEE		33.5023401153
77PhosphorylationRPLGPTPSQSRFQVD
CCCCCCCCCCCEEEE		43.1823401153
79PhosphorylationLGPTPSQSRFQVDLV
CCCCCCCCCEEEEEC		39.1230266825
87PhosphorylationRFQVDLVSENAGRAA
CEEEEECCCCHHHHH		32.2228348404
114UbiquitinationAGAGAGAKQTPADGE
HCCCCCCCCCCCCCC		54.5121906983
114 (in isoform 1)Ubiquitination-54.5121890473
114 (in isoform 3)Ubiquitination-54.5121890473
116PhosphorylationAGAGAKQTPADGEAS
CCCCCCCCCCCCCCC		21.5321815630
123PhosphorylationTPADGEASGESEPAK
CCCCCCCCCCCCCCC		38.5025849741
126PhosphorylationDGEASGESEPAKGSE
CCCCCCCCCCCCCCH		53.0228985074
130UbiquitinationSGESEPAKGSEEAKG
CCCCCCCCCCHHHCC		73.9321906983
130 (in isoform 1)Ubiquitination-73.9321890473
130 (in isoform 3)Ubiquitination-73.9321890473
132PhosphorylationESEPAKGSEEAKGRF
CCCCCCCCHHHCCCE		31.4029496963
136UbiquitinationAKGSEEAKGRFRVNF
CCCCHHHCCCEEEEE		54.63-
203PhosphorylationHQHYYYDTHTNTYYL
CCCEEEECCCCEEEE		17.9320442269
207PhosphorylationYYDTHTNTYYLRTFG
EEECCCCEEEEEECC		18.0720442269
208PhosphorylationYDTHTNTYYLRTFGH
EECCCCEEEEEECCC		11.5425884760
212PhosphorylationTNTYYLRTFGHNTMD
CCEEEEEECCCCCCC		31.2330266825
217PhosphorylationLRTFGHNTMDAVPRI
EEECCCCCCCCCCCC		15.6830266825
227PhosphorylationAVPRIDHYRHTAAQL
CCCCCCHHHHHHHHH		10.5921945579
230PhosphorylationRIDHYRHTAAQLGEK
CCCHHHHHHHHHHHH		18.0621945579
237UbiquitinationTAAQLGEKLLRPSLA
HHHHHHHHHHCHHHH		51.53-
237 (in isoform 1)Ubiquitination-51.5321890473
237 (in isoform 3)Ubiquitination-51.5321890473
242PhosphorylationGEKLLRPSLAELHDE
HHHHHCHHHHHHHHH		33.5020442269
252UbiquitinationELHDELEKEPFEDGF
HHHHHHHCCCCCCCC		81.1421906983
252 (in isoform 1)Ubiquitination-81.1421890473
252 (in isoform 3)Ubiquitination-81.1421890473
265PhosphorylationGFANGEESTPTRDAV
CCCCCCCCCCCCCEE		35.0730266825
266PhosphorylationFANGEESTPTRDAVV
CCCCCCCCCCCCEEE		31.7730266825
268PhosphorylationNGEESTPTRDAVVTY
CCCCCCCCCCEEEEE		41.0730266825
274PhosphorylationPTRDAVVTYTAESKG
CCCCEEEEEEECCCC		14.4621945579
275PhosphorylationTRDAVVTYTAESKGV
CCCEEEEEEECCCCE		7.7321945579
276PhosphorylationRDAVVTYTAESKGVV
CCEEEEEEECCCCEE		18.0021945579
279PhosphorylationVVTYTAESKGVVKFG
EEEEEECCCCEEEEH		32.0421945579
280UbiquitinationVTYTAESKGVVKFGW
EEEEECCCCEEEEHH		47.4321906983
280 (in isoform 1)Ubiquitination-47.4321890473
280 (in isoform 3)Ubiquitination-47.4321890473
353PhosphorylationFVRGGGAYYLISRSL
CEECCCCEEEEEHHH		11.33-
399PhosphorylationVELLKEHSILMIDEI
HHHHHHCCEEEEEEC		20.6422210691
424PhosphorylationVVILLGISVAGMEWE
HHHHHCCHHHCCCHH		12.2422210691
711PhosphorylationWRPAFKYYNMWISLL
CCHHHHHHHHHHHHH		10.1128787133
785UbiquitinationSGVEDHVKNFRPQCL
CCHHHHHHHCCCCEE		47.12-
833MethylationGPRRQAMKEMSIDQA
CHHHHHHHHCCCCHH		53.9654403003
833UbiquitinationGPRRQAMKEMSIDQA
CHHHHHHHHCCCCHH		53.96-
836PhosphorylationRQAMKEMSIDQAKYQ
HHHHHHCCCCHHHHH		24.8924719451
841UbiquitinationEMSIDQAKYQRWLIK
HCCCCHHHHHHHHHH		35.96-
842PhosphorylationMSIDQAKYQRWLIKN
CCCCHHHHHHHHHHH		13.3124719451
848UbiquitinationKYQRWLIKNKMKAFY
HHHHHHHHHHHHHHC		48.63-
850UbiquitinationQRWLIKNKMKAFYAP
HHHHHHHHHHHHCCC		36.45-
852MalonylationWLIKNKMKAFYAPVH
HHHHHHHHHHCCCCC		36.6330639696
855PhosphorylationKNKMKAFYAPVHADD
HHHHHHHCCCCCHHH		18.1723403867
923UbiquitinationGVVVIRLKEGLDISH
EEEEEEECCCCCHHH		39.6321906983
923 (in isoform 1)Ubiquitination-39.6321890473
923 (in isoform 3)Ubiquitination-39.6321890473
929PhosphorylationLKEGLDISHLQGQEE
ECCCCCHHHHCCHHH		20.1520068231
939PhosphorylationQGQEELLSSQEKSPG
CCHHHHHHCCCCCCC		42.4730266825
940PhosphorylationGQEELLSSQEKSPGT
CHHHHHHCCCCCCCC		42.1817525332
943UbiquitinationELLSSQEKSPGTKDV
HHHHCCCCCCCCCCE		55.0721906983
943 (in isoform 1)Ubiquitination-55.0721890473
943 (in isoform 3)Ubiquitination-55.0721890473
944PhosphorylationLLSSQEKSPGTKDVV
HHHCCCCCCCCCCEE		28.0126055452
947PhosphorylationSQEKSPGTKDVVVSV
CCCCCCCCCCEEEEE		27.7026074081
948UbiquitinationQEKSPGTKDVVVSVE
CCCCCCCCCEEEEEE		55.2122053931
948 (in isoform 1)Ubiquitination-55.2121890473
948 (in isoform 3)Ubiquitination-55.2121890473
953PhosphorylationGTKDVVVSVEYSKKS
CCCCEEEEEEEECHH		9.5329978859
956PhosphorylationDVVVSVEYSKKSDLD
CEEEEEEEECHHCCC		24.5128152594
957PhosphorylationVVVSVEYSKKSDLDT
EEEEEEEECHHCCCC		21.8028152594
958UbiquitinationVVSVEYSKKSDLDTS
EEEEEEECHHCCCCC		56.2321906983
958 (in isoform 1)Ubiquitination-56.2321890473
958 (in isoform 3)Ubiquitination-56.2321890473
959UbiquitinationVSVEYSKKSDLDTSK
EEEEEECHHCCCCCC		43.1721906983
959 (in isoform 1)Ubiquitination-43.1721890473
959 (in isoform 3)Ubiquitination-43.1721890473
964PhosphorylationSKKSDLDTSKPLSEK
ECHHCCCCCCCCCCC		46.0424275569
965PhosphorylationKKSDLDTSKPLSEKP
CHHCCCCCCCCCCCC		31.7624719451
966UbiquitinationKSDLDTSKPLSEKPI
HHCCCCCCCCCCCCC		52.6621906983
966 (in isoform 1)Ubiquitination-52.6621890473
966 (in isoform 3)Ubiquitination-52.6621890473
971UbiquitinationTSKPLSEKPITHKVE
CCCCCCCCCCCCCCC		38.0421906983
971 (in isoform 1)Ubiquitination-38.0421890473
971 (in isoform 3)Ubiquitination-38.0421890473
974 (in isoform 3)Phosphorylation-24.9528348404
976UbiquitinationSEKPITHKVEEEDGK
CCCCCCCCCCCCCCC		42.5721906983
976 (in isoform 1)Ubiquitination-42.5721890473
976 (in isoform 3)Ubiquitination-42.57-
978 (in isoform 3)Phosphorylation-61.5528348404
979 (in isoform 3)Ubiquitination-65.4621890473
983UbiquitinationKVEEEDGKTATQPLL
CCCCCCCCCCCHHHC		47.51983
983 (in isoform 1)Ubiquitination-47.5121890473
984PhosphorylationVEEEDGKTATQPLLK
CCCCCCCCCCHHHCC		40.2326074081
986PhosphorylationEEDGKTATQPLLKKE
CCCCCCCCHHHCCCC		35.6326074081
991UbiquitinationTATQPLLKKESKGPI
CCCHHHCCCCCCCCC		63.2821906983
991 (in isoform 1)Ubiquitination-63.2821890473
991 (in isoform 3)Ubiquitination-63.2821890473
994PhosphorylationQPLLKKESKGPIVPL
HHHCCCCCCCCCEEC		52.3623401153
995UbiquitinationPLLKKESKGPIVPLN
HHCCCCCCCCCEECC		70.5621906983
995 (in isoform 1)Ubiquitination-70.5621890473
1001 (in isoform 3)Ubiquitination-5.8021890473
1007UbiquitinationPLNVADQKLLEASTQ
ECCHHHHHHHHHHHH		56.4321890473
1007 (in isoform 1)Ubiquitination-56.4321890473
1012PhosphorylationDQKLLEASTQFQKKQ
HHHHHHHHHHHHHHC		17.2323312004
1013PhosphorylationQKLLEASTQFQKKQG
HHHHHHHHHHHHHCC		40.2123312004
10172-HydroxyisobutyrylationEASTQFQKKQGKNTI
HHHHHHHHHCCCCCE		48.64-
1017UbiquitinationEASTQFQKKQGKNTI
HHHHHHHHHCCCCCE		48.6421906983
1017 (in isoform 1)Ubiquitination-48.6421890473
1045 (in isoform 3)Ubiquitination-40.6121890473
1061MalonylationIRVFIGGKINRIDHD
EEEEECCCCCCCCCC		31.4326320211
1061UbiquitinationIRVFIGGKINRIDHD
EEEEECCCCCCCCCC		31.43-
1061 (in isoform 1)Ubiquitination-31.4321890473
1074PhosphorylationHDRRAMATLLSKFRI
CCHHHHHHHHHHHCC		18.3623312004
1077PhosphorylationRAMATLLSKFRIDFS
HHHHHHHHHHCCCHH		32.6224719451
1078UbiquitinationAMATLLSKFRIDFSD
HHHHHHHHHCCCHHH		38.33-
1079 (in isoform 3)Ubiquitination-8.1121890473
1082 (in isoform 3)Ubiquitination-32.5121890473
1095UbiquitinationVLGDINTKPKKENII
EEECCCCCCCCCCEE		50.8021906983
1095 (in isoform 1)Ubiquitination-50.8021890473
1097UbiquitinationGDINTKPKKENIIAF
ECCCCCCCCCCEEEE		74.42-
1098SumoylationDINTKPKKENIIAFE
CCCCCCCCCCEEEEE		65.60-
1098UbiquitinationDINTKPKKENIIAFE
CCCCCCCCCCEEEEE		65.6021906983
1098 (in isoform 1)Ubiquitination-65.6021890473
1102 (in isoform 3)Ubiquitination-5.6121890473
1109 (in isoform 3)Ubiquitination-41.7721890473
1118UbiquitinationYRLHEDDKEQDIADK
HCCCCCCCCCHHHHH		70.3821906983
1118 (in isoform 1)Ubiquitination-70.3821890473
1125UbiquitinationKEQDIADKMKEDEPW
CCCHHHHHHCCCCCC		42.7321906983
1125 (in isoform 1)Ubiquitination-42.7321890473
1127UbiquitinationQDIADKMKEDEPWRI
CHHHHHHCCCCCCCC		68.69-
1127 (in isoform 3)Ubiquitination-68.6921890473
1142PhosphorylationTDNELELYKTKTYRQ
CCCCHHHHHCCHHHH		13.7730631047
1143UbiquitinationDNELELYKTKTYRQI
CCCHHHHHCCHHHHH		57.052190698
1143 (in isoform 1)Ubiquitination-57.0521890473
1144PhosphorylationNELELYKTKTYRQIR
CCHHHHHCCHHHHHH		18.3030631047
1146PhosphorylationLELYKTKTYRQIRLN
HHHHHCCHHHHHHHH		29.2127966365
1147PhosphorylationELYKTKTYRQIRLNE
HHHHCCHHHHHHHHH		11.3227966365
1211PhosphorylationHQSVLTFYS------
CCEEEEEEC------		14.2923312004
1212PhosphorylationQSVLTFYS-------
CEEEEEEC-------		29.5623312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
77SPhosphorylationKinaseAMPKA1Q13131
PSP
77SPhosphorylationKinaseAMPKA1P54645
PSP
203TPhosphorylationKinaseOXSR1O95747
GPS
203TPhosphorylationKinaseSTK39Q9UEW8
GPS
207TPhosphorylationKinaseOXSR1O95747
GPS
207TPhosphorylationKinaseSTK39Q9UEW8
GPS
212TPhosphorylationKinaseOXSR1O95747
GPS
212TPhosphorylationKinaseSTK39Q9UEW8
GPS
217TPhosphorylationKinaseOXSR1O95747
GPS
230TPhosphorylationKinaseOXSR1O95747
GPS
242SPhosphorylationKinaseAMPKA1Q13131
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S12A2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S12A2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
S12A2_HUMANSLC12A2physical
10736171
SEC13_HUMANSEC13physical
22939629
COMD1_HUMANCOMMD1physical
23515529
GBG12_HUMANGNG12physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00247 Bumetanide (JP16/USP/INN); Bumex (TN)
D00313 Etacrynic acid (JP16/INN); Ethacrynic acid (USP)
D00331 Furosemide (JP16/USP/INN); Frusemide; Lasix (TN)
D00382 Torasemide (JAN/INN); Torsemide (USP); Demadex (TN); Luprac (TN)
D01323 Azosemide (JAN/USAN/INN); Diart (TN)
D01634 Piretanide (JAN/USAN/INN); Arelix (TN)
D01895 Tripamide (JAN/USAN/INN); Normonal (TN)
D04079 Ethacrynate sodium (USP)
D05093 Muzolimine (USAN/INN)
D07999 Sodium furosemide; Frosemide sodium; Lasix (TN)
D08001 Furosemide diolamine; Furosemide diethanolamine salt; Nuriban (TN)
D08619 Torasemide sodium; Torem (TN)
D09772 Alilusem potassium (JAN); M17055
DrugBank
DB00887Bumetanide
DB00761Potassium Chloride
DB01325Quinethazone
Regulatory Network of S12A2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-79 AND SER-994,AND MASS SPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266, AND MASSSPECTROMETRY.

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