CAMLG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAMLG_HUMAN
• UniProt AC: P49069
• Protein Name: Calcium signal-modulating cyclophilin ligand
• Gene Name: CAMLG
• Organism: Homo sapiens (Human).
• Sequence Length: 296
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B..
• Protein Sequence: MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESMAVATDG -----CCCCEEECCC	15.67	26074081
8	Phosphorylation	MESMAVATDGGERPG CCCCEEECCCCCCCC	28.69	19664995
20	Phosphorylation	RPGVPAGSGLSASQR CCCCCCCCCCCHHHH	38.37	22199227
23	Phosphorylation	VPAGSGLSASQRRAE CCCCCCCCHHHHHHH	29.42	22199227
25	Phosphorylation	AGSGLSASQRRAELR CCCCCCHHHHHHHHH	22.35	22199227
40	Phosphorylation	RRKLLMNSEQRINRI HHHHHCCHHHHHHHH	22.57	25159151
55	Phosphorylation	MGFHRPGSGAEEESQ HCCCCCCCCCHHHHH	37.20	23927012
61	Phosphorylation	GSGAEEESQTKSKQQ CCCCHHHHHCCCCCC	46.56	23403867
63	Phosphorylation	GAEEESQTKSKQQDS CCHHHHHCCCCCCCH	46.71	23403867
72	Acetylation	SKQQDSDKLNSLSVP CCCCCHHHHHCCCCC	54.22	20167786
75	Phosphorylation	QDSDKLNSLSVPSVS CCHHHHHCCCCCCCC	32.24	24173317
77	Phosphorylation	SDKLNSLSVPSVSKR HHHHHCCCCCCCCCE	31.63	23403867
80	Phosphorylation	LNSLSVPSVSKRVVL HHCCCCCCCCCEEEC	36.55	23403867
83	Acetylation	LSVPSVSKRVVLGDS CCCCCCCCEEECCCC	47.24	20167786
116	Phosphorylation	QLGDKLDSFIKPPEC CCHHHHHHHCCCCCC	39.03	24719451
124	Phosphorylation	FIKPPECSSDVNLEL HCCCCCCCCCCCHHH	28.10	28348404
125	Phosphorylation	IKPPECSSDVNLELR CCCCCCCCCCCHHHH	58.18	28348404
140	Phosphorylation	QRNRGDLTADSVQRG HHCCCCCCHHHHHHH	32.91	23403867
143	Phosphorylation	RGDLTADSVQRGSRH CCCCCHHHHHHHHHH	20.06	21815630
146	Methylation	LTADSVQRGSRHGLE CCHHHHHHHHHHHHH	42.79	-
148	Phosphorylation	ADSVQRGSRHGLEQY HHHHHHHHHHHHHHH	24.24	20363803
155	Phosphorylation	SRHGLEQYLSRFEEA HHHHHHHHHHHHHHH	9.40	27642862
164	Ubiquitination	SRFEEAMKLRKQLIS HHHHHHHHHHHHHHH	52.79	-
171	Phosphorylation	KLRKQLISEKPSQED HHHHHHHHCCCCCCC	48.43	24719451
173	Ubiquitination	RKQLISEKPSQEDGN HHHHHHCCCCCCCCC	43.08	27667366
175	Phosphorylation	QLISEKPSQEDGNTT HHHHCCCCCCCCCCC	58.22	22496350
233	Ubiquitination	GLYKYFPKSEKKIKT HHHHHCCCCHHHHHH	62.44	27667366
250	Phosphorylation	LTAALLLSGIPAEVI HHHHHHHCCCCHHHH	34.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAMLG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAMLG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAMLG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGFR_HUMAN	EGFR	physical	12919676
TR13B_HUMAN	TNFRSF13B	physical	9311921
TR13B_HUMAN	TNFRSF13B	physical	10880535
TMUB1_HUMAN	TMUB1	physical	20582322
KCNA2_HUMAN	KCNA2	physical	25416956
WRB_HUMAN	WRB	physical	26186194
ASNA_HUMAN	ASNA1	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00091: Cyclosporine