KCNA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNA2_HUMAN
• UniProt AC: P16389
• Protein Name: Potassium voltage-gated channel subfamily A member 2
• Gene Name: KCNA2
• Organism: Homo sapiens (Human).
• Sequence Length: 499
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Membrane . Cell projection, axon . Cell junction, synapse . Endoplasmic reticulum membrane . Cell projection, lamellipodium membrane . Cell junction, synapse, synaptosome . Cell junction, synapse, presynaptic
• Protein Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. [PubMed: 19912772]
• Protein Sequence: MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	ERVVINISGLRFETQ CEEEEECCCCCHHHH	27.56	24719451
49	Ubiquitination	LRFETQLKTLAQFPE CCHHHHHHHHHHCCH	31.51	30230243
64	Ubiquitination	TLLGDPKKRMRYFDP HHHCCHHHCCCCCCC	57.74	30230243
76	Phosphorylation	FDPLRNEYFFDRNRP CCCCCCCCCCCCCCC	17.07	-
84	Phosphorylation	FFDRNRPSFDAILYY CCCCCCCCCCEEEEE	32.30	-
90	Phosphorylation	PSFDAILYYYQSGGR CCCCEEEEEECCCCC	8.26	22817900
91	Phosphorylation	SFDAILYYYQSGGRL CCCEEEEEECCCCCC	7.50	22817900
92	Phosphorylation	FDAILYYYQSGGRLR CCEEEEEECCCCCCC	5.22	22817900
132	Phosphorylation	MFREDEGYIKEEERP HHHHCCCCCCCCCCC	13.53	22817900
207	N-linked_Glycosylation	VTFHTYSNSTIGYQQ CEEEEECCCCEEEEC	32.53	12911333
207	N-linked_Glycosylation	VTFHTYSNSTIGYQQ CEEEEECCCCEEEEC	32.53	12911333
244	S-palmitoylation	FLVRFFACPSKAGFF HHHHHHCCCCCCCCC	3.10	-
308	Phosphorylation	VFRIFKLSRHSKGLQ HHHHHHHCCCCCHHH	28.65	26074081
415	Phosphorylation	VIVSNFNYFYHRETE EEEECCCEEEECCCC	11.02	22817900
417	Phosphorylation	VSNFNYFYHRETEGE EECCCEEEECCCCCH	6.93	22817900
429	Phosphorylation	EGEEQAQYLQVTSCP CCHHHHHEEEEECCC	11.34	27196784
433	Phosphorylation	QAQYLQVTSCPKIPS HHHEEEEECCCCCCC	16.20	25332170
434	Phosphorylation	AQYLQVTSCPKIPSS HHEEEEECCCCCCCC	29.57	24076635
440	Phosphorylation	TSCPKIPSSPDLKKS ECCCCCCCCCCHHCC	58.96	22817900
441	Phosphorylation	SCPKIPSSPDLKKSR CCCCCCCCCCHHCCC	19.65	22817900
447	Phosphorylation	SSPDLKKSRSASTIS CCCCHHCCCCCCCCC	29.85	25332170
449	Phosphorylation	PDLKKSRSASTISKS CCHHCCCCCCCCCHH	33.39	27794612
451	Phosphorylation	LKKSRSASTISKSDY HHCCCCCCCCCHHHH	27.76	27794612
452	Phosphorylation	KKSRSASTISKSDYM HCCCCCCCCCHHHHH	29.05	23532336
454	Phosphorylation	SRSASTISKSDYMEI CCCCCCCCHHHHHHH	26.62	27794612
458	Phosphorylation	STISKSDYMEIQEGV CCCCHHHHHHHHHHC	12.07	-
468	Phosphorylation	IQEGVNNSNEDFREE HHHHCCCCCHHHHHH	36.07	24076635
479	Phosphorylation	FREENLKTANCTLAN HHHHHHHHCCCEECC	26.69	29083192
483	Phosphorylation	NLKTANCTLANTNYV HHHHCCCEECCCCCE	28.81	29083192
487	Phosphorylation	ANCTLANTNYVNITK CCCEECCCCCEEHHE	23.48	29083192
489	Phosphorylation	CTLANTNYVNITKML CEECCCCCEEHHEEE	7.88	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
440	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
441	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
449	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNA1_HUMAN	KCNA1	physical	10428084
KCNA4_HUMAN	KCNA4	physical	10428084
KCAB2_HUMAN	KCNAB2	physical	10428084
SRC8_HUMAN	CTTN	physical	12151401
KCAB1_HUMAN	KCNAB1	physical	8636142
KCAB2_HUMAN	KCNAB2	physical	8636142
PTPRA_HUMAN	PTPRA	physical	9878055
KCNA2_HUMAN	KCNA2	physical	8980147
KCNA5_HUMAN	KCNA5	physical	11149959
SRC8_HUMAN	CTTN	physical	17959782

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616366: Epileptic encephalopathy, early infantile, 32 (EIEE32)
• Kegg Drug
• D01554: Pilsicainide hydrochloride hydrate (JAN); Pilsicainide hydrochloride; SUN 1165 (TN); Sunrythm (TN)
• D08377: Pilsicainide (INN)
• DrugBank
• There are no disease associations of PTM sites.