DGKE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DGKE_HUMAN
• UniProt AC: P52429
• Protein Name: Diacylglycerol kinase epsilon
• Gene Name: DGKE
• Organism: Homo sapiens (Human).
• Sequence Length: 567
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Membrane . Cytoplasm .
• Protein Description: Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition..
• Protein Sequence: MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMMLYFSGEQTDDDISSTSDQEDIKATE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Acetylation	VDEGCLRKADKRFQC CCHHHHHHCCCCCCC	48.25	30588123
109	Ubiquitination	ADKRFQCKEIMLKND CCCCCCCEEEECCCC	39.22	-
169	Ubiquitination	TVHDECMKNSLKNEK HHCHHHHHHHHCCCC	55.85	-
176	Ubiquitination	KNSLKNEKCDFGEFK HHHHCCCCCCCHHCC	48.80	-
203	Ubiquitination	NQMRKDKKTDYEVLA HHHHCCCCCCHHHHH	57.68	-
206	Phosphorylation	RKDKKTDYEVLASKL HCCCCCCHHHHHHHH	17.11	27642862
212	Ubiquitination	DYEVLASKLGKQWTP CHHHHHHHHCCCCCE	56.50	-
215	Ubiquitination	VLASKLGKQWTPLII HHHHHHCCCCCEEEE	53.77	-
254	Ubiquitination	VQVFDVTKTPPIKAL EEEEECCCCCCCHHH	59.90	-
265	Phosphorylation	IKALQLCTLLPYYSA CHHHHHHHHHHHCEE	39.66	-
351	Ubiquitination	GIKLDRWKVQVTNKG CCEECEEEEEEECCC	24.55	-
355	Phosphorylation	DRWKVQVTNKGYYNL CEEEEEEECCCCCCC	17.70	26074081
357	Ubiquitination	WKVQVTNKGYYNLRK EEEEEECCCCCCCCC	38.63	21890473
359	Phosphorylation	VQVTNKGYYNLRKPK EEEECCCCCCCCCCC	7.26	26074081
360	Phosphorylation	QVTNKGYYNLRKPKE EEECCCCCCCCCCCE	19.18	26074081
375	Phosphorylation	FTMNNYFSVGPDALM EECCCCEEECHHHHH	18.79	22210691
392	Ubiquitination	NFHAHREKAPSLFSS CCHHCHHHCCCHHHH	66.60	-
399	Phosphorylation	KAPSLFSSRILNKAV HCCCHHHHHHHHCHH	18.92	22210691
404	Ubiquitination	FSSRILNKAVYLFYG HHHHHHHCHHHHHHC	35.47	-
413	Ubiquitination	VYLFYGTKDCLVQEC HHHHHCCHHHHHHHH	41.92	-
558	Phosphorylation	DDDISSTSDQEDIKA CCCCCCCCCHHHHHH	38.96	24245541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DGKE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DGKE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DGKE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUDC_HUMAN	NUDC	physical	17353931
SET_HUMAN	SET	physical	17353931
PUR6_HUMAN	PAICS	physical	17353931
NUF2_HUMAN	NUF2	physical	17353931
ODPA_HUMAN	PDHA1	physical	17353931
RM44_HUMAN	MRPL44	physical	21988832
IFT46_HUMAN	IFT46	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615008: Nephrotic syndrome 7 (NPHS7)
• 615008: Hemolytic uremic syndrome atypical 7 (AHUS7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.