SMOC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMOC1_HUMAN
• UniProt AC: Q9H4F8
• Protein Name: SPARC-related modular calcium-binding protein 1
• Gene Name: SMOC1
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane . In or around the basement membrane.
• Protein Description: Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation..
• Protein Sequence: MLPARCARLLTPHLLLVLVQLSPARGHRTTGPRFLISDRDPQCNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVYSCDQERQSALEEAQQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKTTEADDPFKDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEGRLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	O-linked_Glycosylation	TGPRFLISDRDPQCN CCCCEECCCCCCCCC	28.83	55835975
48	Phosphorylation	PQCNLHCSRTQPKPI CCCCCCCCCCCCCCE	27.84	27134283
53	Ubiquitination	HCSRTQPKPICASDG CCCCCCCCCEECCCC	36.88	-
147	Phosphorylation	TPDGKPISGSSVQNK CCCCCCCCCCCCCCC	40.94	23879269
149	Phosphorylation	DGKPISGSSVQNKTP CCCCCCCCCCCCCCC	22.12	23879269
150	Phosphorylation	GKPISGSSVQNKTPV CCCCCCCCCCCCCCC	31.11	23879269
155	Phosphorylation	GSSVQNKTPVCSGSV CCCCCCCCCCCCCCC	28.62	25159151
163	Phosphorylation	PVCSGSVTDKPLSQG CCCCCCCCCCCCCCC	39.75	23879269
163	O-linked_Glycosylation	PVCSGSVTDKPLSQG CCCCCCCCCCCCCCC	39.75	55827347
165	Ubiquitination	CSGSVTDKPLSQGNS CCCCCCCCCCCCCCC	38.19	-
168	O-linked_Glycosylation	SVTDKPLSQGNSGRK CCCCCCCCCCCCCCC	44.56	55827353
172	O-linked_Glycosylation	KPLSQGNSGRKDDGS CCCCCCCCCCCCCCC	46.96	55827359
184	O-linked_Glycosylation	DGSKPTPTMETQPVF CCCCCCCCCCCCCCC	30.07	OGP
197	O-linked_Glycosylation	VFDGDEITAPTLWIK CCCCCCCCCCCEEEE	25.24	OGP
212	Ubiquitination	HLVIKDSKLNNTNIR EEEECCCCCCCCCCC	66.42	-
214	N-linked_Glycosylation	VIKDSKLNNTNIRNS EECCCCCCCCCCCCC	57.95	20068230
214	N-linked_Glycosylation	VIKDSKLNNTNIRNS EECCCCCCCCCCCCC	57.95	UniProtKB CARBOHYD
300	O-linked_Glycosylation	ESDARAKTTEADDPF CCHHCCCCCCCCCCC	28.96	104413
301	O-linked_Glycosylation	SDARAKTTEADDPFK CHHCCCCCCCCCCCC	28.59	55823749
308	Ubiquitination	TEADDPFKDRELPGC CCCCCCCCCCCCCCC	62.35	-
351	O-linked_Glycosylation	PTGGGRFSEPDPSHT CCCCCCCCCCCCCCC	47.03	55832097
374	N-linked_Glycosylation	YFSQLDSNSSNDINK HHHCCCCCCCCCCCH	49.47	UniProtKB CARBOHYD
390	Phosphorylation	EMKPFKRYVKKKAKP HCHHHHHHHHHHCCC	19.74	26074081
412	Ubiquitination	TDYCDLNKDKVISLP HHHCCCCCCCEEEHH	67.24	-
414	Ubiquitination	YCDLNKDKVISLPEL HCCCCCCCEEEHHHH	42.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMOC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMOC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMOC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
NDKB_HUMAN	NME2	physical	28514442
NAF1_HUMAN	NAF1	physical	28514442
UBR2_HUMAN	UBR2	physical	28514442
PININ_HUMAN	PNN	physical	28514442
CISD3_HUMAN	CISD3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 206920: Ophthalmoacromelic syndrome (OAS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.