CHID1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHID1_HUMAN
• UniProt AC: Q9BWS9
• Protein Name: Chitinase domain-containing protein 1
• Gene Name: CHID1
• Organism: Homo sapiens (Human).
• Sequence Length: 393
• Subcellular Localization: Secreted . Lysosome .
• Protein Description: Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro)..
• Protein Sequence: MRTLFNLLWLALACSPVHTTLSKSDAKKAASKTLLEKSQFSDKPVQDRGLVVTDLKAESVVLEHRSYCSAKARDRHFAGDVLGYVTPWNSHGYDVTKVFGSKFTQISPVWLQLKRRGREMFEVTGLHDVDQGWMRAVRKHAKGLHIVPRLLFEDWTYDDFRNVLDSEDEIEELSKTVVQVAKNQHFDGFVVEVWNQLLSQKRVGLIHMLTHLAEALHQARLLALLVIPPAITPGTDQLGMFTHKEFEQLAPVLDGFSLMTYDYSTAHQPGPNAPLSWVRACVQVLDPKSKWRSKILLGLNFYGMDYATSKDAREPVVGARYIQTLKDHRPRMVWDSQASEHFFEYKKSRSGRHVVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MRTLFNLLWL -----CCHHHHHHHH	34.11	-
32	Ubiquitination	DAKKAASKTLLEKSQ HHHHHHHHHHHHHHC	38.17	27667366
33 (in isoform 2)	Phosphorylation	-	33.80	-
37 (in isoform 3)	Ubiquitination	-	49.91	21906983
37	Ubiquitination	ASKTLLEKSQFSDKP HHHHHHHHHCCCCCC	49.91	2190698
38	Phosphorylation	SKTLLEKSQFSDKPV HHHHHHHHCCCCCCC	27.38	20068231
41	Phosphorylation	LLEKSQFSDKPVQDR HHHHHCCCCCCCCCC	36.77	27050516
43	Ubiquitination	EKSQFSDKPVQDRGL HHHCCCCCCCCCCCE	45.98	29967540
48	Methylation	SDKPVQDRGLVVTDL CCCCCCCCCEEEEEE	24.21	-
56	Ubiquitination	GLVVTDLKAESVVLE CEEEEEECCEEEEEE	53.57	29967540
71	Ubiquitination	HRSYCSAKARDRHFA CCCHHCHHHCCCCCC	27.88	-
81	Ubiquitination	DRHFAGDVLGYVTPW CCCCCCCCCEEECCC	4.34	29967540
90	Phosphorylation	GYVTPWNSHGYDVTK EEECCCCCCCCCHHH	17.89	24247654
98 (in isoform 1)	Ubiquitination	-	4.86	21906983
102	Ubiquitination	VTKVFGSKFTQISPV HHHHCCCCCCCCCHH	53.46	-
104	Phosphorylation	KVFGSKFTQISPVWL HHCCCCCCCCCHHHH	28.82	-
107	Phosphorylation	GSKFTQISPVWLQLK CCCCCCCCHHHHHHH	12.00	-
114	Ubiquitination	SPVWLQLKRRGREMF CHHHHHHHHHCCCCE	27.39	21963094
127 (in isoform 2)	Ubiquitination	-	34.10	-
139 (in isoform 2)	Ubiquitination	-	41.12	-
139	Ubiquitination	GWMRAVRKHAKGLHI HHHHHHHHHCCCCCC	41.12	21963094
142	Ubiquitination	RAVRKHAKGLHIVPR HHHHHHCCCCCCCCC	62.82	29967540
144	Ubiquitination	VRKHAKGLHIVPRLL HHHHCCCCCCCCCHH	2.16	21963094
166	Phosphorylation	DFRNVLDSEDEIEEL HHHHHCCCHHHHHHH	42.67	29449344
167	Ubiquitination	FRNVLDSEDEIEELS HHHHCCCHHHHHHHH	60.37	29967540
175	Ubiquitination	DEIEELSKTVVQVAK HHHHHHHHHHHHHHH	58.94	29967540
199	Ubiquitination	EVWNQLLSQKRVGLI HHHHHHHHHHHHHHH	42.10	21963094
200	Ubiquitination	VWNQLLSQKRVGLIH HHHHHHHHHHHHHHH	37.23	29967540
257	Ubiquitination	APVLDGFSLMTYDYS HHHCCCEEEEEEECC	23.82	29967540
288	Ubiquitination	CVQVLDPKSKWRSKI HHHHCCCCCHHHHHH	65.42	29967540
293	Phosphorylation	DPKSKWRSKILLGLN CCCCHHHHHHHHHCE	23.96	24719451
308	Phosphorylation	FYGMDYATSKDAREP ECCCCCCCCCCCCCC	30.04	24719451
313	Ubiquitination	YATSKDAREPVVGAR CCCCCCCCCCCCCHH	59.91	29967540
315 (in isoform 2)	Ubiquitination	-	22.12	-
318 (in isoform 2)	Phosphorylation	-	12.45	24719451
326	Ubiquitination	ARYIQTLKDHRPRMV HHHHHHHHHCCCCCC	55.67	-
333 (in isoform 2)	Phosphorylation	-	5.61	24719451
350	Phosphorylation	FEYKKSRSGRHVVFY HHEECCCCCCEEEEE	47.47	30631047
351 (in isoform 2)	Ubiquitination	-	23.70	-
359	Phosphorylation	RHVVFYPTLKSLQVR CEEEEECCHHHHHHH	35.12	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHID1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHID1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHID1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
LYAG_HUMAN	GAA	physical	26344197
MA2B1_HUMAN	MAN2B1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.