PRPS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRPS2_HUMAN
• UniProt AC: P11908
• Protein Name: Ribose-phosphate pyrophosphokinase 2
• Gene Name: PRPS2
• Organism: Homo sapiens (Human).
• Sequence Length: 318
• Protein Description: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis..
• Protein Sequence: MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPNIVLFSGSSHQDL CCCEEEECCCCCHHH	33.34	23403867
10	Phosphorylation	NIVLFSGSSHQDLSQ CEEEECCCCCHHHHH	24.37	23403867
11	Phosphorylation	IVLFSGSSHQDLSQR EEEECCCCCHHHHHH	28.79	23403867
16	Phosphorylation	GSSHQDLSQRVADRL CCCCHHHHHHHHHHH	24.99	23403867
29 (in isoform 2)	Ubiquitination	-	46.27	21890473
29	Ubiquitination	RLGLELGKVVTKKFS HHCHHHHHHHEEECC	46.27	21890473
29	Acetylation	RLGLELGKVVTKKFS HHCHHHHHHHEEECC	46.27	23236377
29 (in isoform 1)	Ubiquitination	-	46.27	21890473
34	Ubiquitination	LGKVVTKKFSNQETS HHHHHEEECCCCCEE	44.66	21890473
34 (in isoform 1)	Ubiquitination	-	44.66	21890473
34 (in isoform 2)	Ubiquitination	-	44.66	21890473
94	Phosphorylation	AVIPCFPYARQDKKD EEEECCCHHCCCCCC	8.31	28152594
103	Phosphorylation	RQDKKDKSRAPISAK CCCCCCCCCCCCCHH	43.75	28348404
146	Phosphorylation	DIPVDNLYAEPAVLQ CCCCCCCCCCHHHHH	18.38	-
163	Methylation	RENIAEWKNCIIVSP HHHHHHHCCEEEECC	33.18	115975773
176	Ubiquitination	SPDAGGAKRVTSIAD CCCCCCCHHHHHHHH	51.15	-
176	2-Hydroxyisobutyrylation	SPDAGGAKRVTSIAD CCCCCCCHHHHHHHH	51.15	-
176	Acetylation	SPDAGGAKRVTSIAD CCCCCCCHHHHHHHH	51.15	25953088
179 (in isoform 2)	Ubiquitination	-	20.60	-
179	Phosphorylation	AGGAKRVTSIADRLN CCCCHHHHHHHHHHC	20.60	23312004
180	Phosphorylation	GGAKRVTSIADRLNV CCCHHHHHHHHHHCC	16.96	20068231
182 (in isoform 2)	Phosphorylation	-	8.81	27251275
184	Methylation	RVTSIADRLNVEFAL HHHHHHHHHCCEEEE	21.09	115489115
194	Ubiquitination	VEFALIHKERKKANE CEEEEHHHHHHHCCC	52.82	-
194	Acetylation	VEFALIHKERKKANE CEEEEHHHHHHHCCC	52.82	23749302
204	Methylation	KKANEVDRMVLVGDV HHCCCCCEEEEECCH	23.45	-
205	Sulfoxidation	KANEVDRMVLVGDVK HCCCCCEEEEECCHH	2.06	21406390
212 (in isoform 1)	Ubiquitination	-	44.55	21890473
212	Ubiquitination	MVLVGDVKDRVAILV EEEECCHHHCEEEEE	44.55	21890473
212	Acetylation	MVLVGDVKDRVAILV EEEECCHHHCEEEEE	44.55	19820079
212	2-Hydroxyisobutyrylation	MVLVGDVKDRVAILV EEEECCHHHCEEEEE	44.55	-
215 (in isoform 2)	Ubiquitination	-	5.80	21890473
225	Phosphorylation	LVDDMADTCGTICHA EEHHHHCHHHHHHHH	11.87	28857561
228	Phosphorylation	DMADTCGTICHAADK HHHCHHHHHHHHHHH	23.68	28857561
228 (in isoform 2)	Phosphorylation	-	23.68	27251275
235	Ubiquitination	TICHAADKLLSAGAT HHHHHHHHHHHCCCC	46.75	-
235	Acetylation	TICHAADKLLSAGAT HHHHHHHHHHHCCCC	46.75	26051181
238	Phosphorylation	HAADKLLSAGATKVY HHHHHHHHCCCCEEE	34.78	23312004
242	Phosphorylation	KLLSAGATKVYAILT HHHHCCCCEEEHHHH	21.81	-
245	Phosphorylation	SAGATKVYAILTHGI HCCCCEEEHHHHCCC	6.89	28152594
249	Phosphorylation	TKVYAILTHGIFSGP CEEEHHHHCCCCCCH	16.37	28152594
254	Phosphorylation	ILTHGIFSGPAISRI HHHCCCCCCHHHHHH	41.78	28348404
257 (in isoform 2)	Phosphorylation	-	18.86	27251275
259	Phosphorylation	IFSGPAISRINNAAF CCCCHHHHHHCHHHC	29.25	28348404
272	Phosphorylation	AFEAVVVTNTIPQED HCEEEEEECCCCHHH	18.29	30301811
280 (in isoform 1)	Ubiquitination	-	49.44	21890473
280	Ubiquitination	NTIPQEDKMKHCTKI CCCCHHHHCCCCCEE	49.44	2190698
282	Ubiquitination	IPQEDKMKHCTKIQV CCHHHHCCCCCEEEE	41.07	-
283 (in isoform 2)	Ubiquitination	-	22.45	21890473
285 (in isoform 2)	Ubiquitination	-	30.79	-
303	Phosphorylation	LAEAIRRTHNGESVS HHHHHHHHCCCCEEE	15.16	20068231
308	Phosphorylation	RRTHNGESVSYLFSH HHHCCCCEEEEEEEC	20.12	18669648
310	Phosphorylation	THNGESVSYLFSHVP HCCCCEEEEEEECCC	25.95	20068231
311	Phosphorylation	HNGESVSYLFSHVPL CCCCEEEEEEECCCC	15.03	20068231
314	Phosphorylation	ESVSYLFSHVPL--- CEEEEEEECCCC---	22.45	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
180	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRPS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRPS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRPS2_HUMAN	PRPS2	physical	25416956
KPRA_HUMAN	PRPSAP1	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
PRPS1_HUMAN	PRPS1	physical	26186194
KPRA_HUMAN	PRPSAP1	physical	26186194
KPRB_HUMAN	PRPSAP2	physical	26186194
PRI2_HUMAN	PRIM2	physical	26186194
NMT2_HUMAN	NMT2	physical	26186194
KPRA_HUMAN	PRPSAP1	physical	26344197
KPRB_HUMAN	PRPSAP2	physical	26344197
SBDS_HUMAN	SBDS	physical	26344197
KPRB_HUMAN	PRPSAP2	physical	28514442
PRPS1_HUMAN	PRPS1	physical	28514442
KPRA_HUMAN	PRPSAP1	physical	28514442
NMT2_HUMAN	NMT2	physical	28514442
I5P1_HUMAN	INPP5A	physical	28514442
PRI2_HUMAN	PRIM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.