GDF11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDF11_HUMAN
• UniProt AC: O95390
• Protein Name: Growth/differentiation factor 11 {ECO:0000303|PubMed:10391213}
• Gene Name: GDF11
• Organism: Homo sapiens (Human).
• Sequence Length: 407
• Subcellular Localization: Secreted .
• Protein Description: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. [PubMed: 28257634]
• Protein Sequence: MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	O-linked_Glycosylation	RSSRPAPSVAPEPDG CCCCCCCCCCCCCCC	32.77	OGP
81	Phosphorylation	LRLESIKSQILSKLR HHHHHHHHHHHHHHC	22.30	-
85	Phosphorylation	SIKSQILSKLRLKEA HHHHHHHHHHCCCCC	31.13	24719451
94	N-linked_Glycosylation	LRLKEAPNISREVVK HCCCCCCCCCHHHHH	52.49	UniProtKB CARBOHYD
96	Phosphorylation	LKEAPNISREVVKQL CCCCCCCCHHHHHHH	29.09	28787133
167	Phosphorylation	LCCHFHFSPKVMFTK EEEEEECCCHHHHHH	18.42	24719451
232	Phosphorylation	KIELHSRSGHWQSID EEEEECCCCCCEEEC	37.72	29083192
237	Phosphorylation	SRSGHWQSIDFKQVL CCCCCCEEECHHHHH	20.95	29083192
246	Phosphorylation	DFKQVLHSWFRQPQS CHHHHHHHHHCCCCC	24.61	29083192
336	Phosphorylation	WIIAPKRYKANYCSG EEECCCCEECCCCCH	22.15	-
340	Phosphorylation	PKRYKANYCSGQCEY CCCEECCCCCHHCCE	7.89	-
342	Phosphorylation	RYKANYCSGQCEYMF CEECCCCCHHCCEEE	22.87	-
347	Phosphorylation	YCSGQCEYMFMQKYP CCCHHCCEEEEECCC	11.86	-
367	Phosphorylation	QQANPRGSAGPCCTP ECCCCCCCCCCCCCC	31.19	22210691
373	Phosphorylation	GSAGPCCTPTKMSPI CCCCCCCCCCCCCCC	40.48	22210691
375	Phosphorylation	AGPCCTPTKMSPINM CCCCCCCCCCCCCEE	22.64	22210691
378	Phosphorylation	CCTPTKMSPINMLYF CCCCCCCCCCEEEEE	24.96	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDF11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDF11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDF11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GDF11_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.