COCH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COCH_HUMAN
• UniProt AC: O43405
• Protein Name: Cochlin
• Gene Name: COCH
• Organism: Homo sapiens (Human).
• Sequence Length: 550
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Plays a role in the control of cell shape and motility in the trabecular meshwork..
• Protein Sequence: MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	N-linked_Glycosylation	YSLPGRENYSSVDAN EECCCCCCCCCCCCC	40.40	UniProtKB CARBOHYD
102	Phosphorylation	LPGRENYSSVDANGI CCCCCCCCCCCCCCH	35.15	27732954
103	Phosphorylation	PGRENYSSVDANGIQ CCCCCCCCCCCCCHH	17.41	27732954
120	Phosphorylation	MLSRWSASFTVTKGK HHHHEEEEEEEECCC	18.88	-
122	Phosphorylation	SRWSASFTVTKGKSS HHEEEEEEEECCCCC	25.44	-
124	Phosphorylation	WSASFTVTKGKSSTQ EEEEEEEECCCCCCC	30.90	-
124	O-linked_Glycosylation	WSASFTVTKGKSSTQ EEEEEEEECCCCCCC	30.90	46190039
129	Phosphorylation	TVTKGKSSTQEATGQ EEECCCCCCCEECCC	37.28	-
134	O-linked_Glycosylation	KSSTQEATGQAVSTA CCCCCEECCCCCCCC	29.13	OGP
139	O-linked_Glycosylation	EATGQAVSTAHPPTG EECCCCCCCCCCCCC	23.92	55834651
139	Phosphorylation	EATGQAVSTAHPPTG EECCCCCCCCCCCCC	23.92	24043423
140	O-linked_Glycosylation	ATGQAVSTAHPPTGK ECCCCCCCCCCCCCC	23.53	55834657
140	Phosphorylation	ATGQAVSTAHPPTGK ECCCCCCCCCCCCCC	23.53	24043423
145	O-linked_Glycosylation	VSTAHPPTGKRLKKT CCCCCCCCCCCCCCC	60.84	55834663
145	Phosphorylation	VSTAHPPTGKRLKKT CCCCCCCCCCCCCCC	60.84	24043423
199	Phosphorylation	ALMLGIGTEGPHVGL HHHCCCCCCCCEEEE	35.53	26091039
210	Phosphorylation	HVGLVQASEHPKIEF EEEEEECCCCCCEEE	21.24	26091039
218	Phosphorylation	EHPKIEFYLKNFTSA CCCCEEEEECCCCCH	12.18	26091039
221	N-linked_Glycosylation	KIEFYLKNFTSAKDV CEEEEECCCCCHHHH	42.72	UniProtKB CARBOHYD
223	Phosphorylation	EFYLKNFTSAKDVLF EEEECCCCCHHHHEE	36.85	26091039
224	Phosphorylation	FYLKNFTSAKDVLFA EEECCCCCHHHHEEE	29.23	26091039
257	O-linked_Glycosylation	HTAQKFFTVDAGVRK HHHHHEEEECHHHHC	22.17	55831013
330	Phosphorylation	CRNNGFFSYHMPNWF HCCCCCCCEECCCCC	16.33	29978859
331	Phosphorylation	RNNGFFSYHMPNWFG CCCCCCCEECCCCCC	9.29	29978859
339	Phosphorylation	HMPNWFGTTKYVKPL ECCCCCCCHHCHHHH	15.61	29978859
340	Phosphorylation	MPNWFGTTKYVKPLV CCCCCCCHHCHHHHH	22.28	29978859
342	Phosphorylation	NWFGTTKYVKPLVQK CCCCCHHCHHHHHHH	16.18	29978859
439	Phosphorylation	AVIRNIRYMSGGTAT HHHEEEEEECCCCCC	7.58	23532336
441	Phosphorylation	IRNIRYMSGGTATGD HEEEEEECCCCCCCC	25.74	25072903
444	Phosphorylation	IRYMSGGTATGDAIS EEEECCCCCCCCEEE	25.27	25072903
446	Phosphorylation	YMSGGTATGDAISFT EECCCCCCCCEEEEE	35.12	25072903
451	Phosphorylation	TATGDAISFTVRNVF CCCCCEEEEEEEECC	19.31	25072903
453	Phosphorylation	TGDAISFTVRNVFGP CCCEEEEEEEECCCC	16.27	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COCH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COCH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COCH_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of COCH_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.