GNPTG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNPTG_HUMAN
• UniProt AC: Q9UJJ9
• Protein Name: N-acetylglucosamine-1-phosphotransferase subunit gamma
• Gene Name: GNPTG
• Organism: Homo sapiens (Human).
• Sequence Length: 305
• Subcellular Localization: Secreted . Golgi apparatus .
• Protein Description: Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors..
• Protein Sequence: MAAGLARLLLLLGLSAGGPAPAGAAKMKVVEEPNAFGVNNPFLPQASRLQAKRDPSPVSGPVHLFRLSGKCFSLVESTYKYEFCPFHNVTQHEQTFRWNAYSGILGIWHEWEIANNTFTGMWMRDGDACRSRSRQSKVELACGKSNRLAHVSEPSTCVYALTFETPLVCHPHALLVYPTLPEALQRQWDQVEQDLADELITPQGHEKLLRTLFEDAGYLKTPEENEPTQLEGGPDSLGFETLENCRKAHKELSKEIKRLKGLLTQHGIPYTRPTETSNLEHLGHETPRAKSPEQLRGDPGLRGSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LLLLLGLSAGGPAPA HHHHHHHHCCCCCCC	24.06	20068231
56	Phosphorylation	LQAKRDPSPVSGPVH HHCCCCCCCCCCCEE	42.07	23312004
87	Ubiquitination	KYEFCPFHNVTQHEQ CEEECCCCCCCCCCE	17.00	22817900
88	N-linked_Glycosylation	YEFCPFHNVTQHEQT EEECCCCCCCCCCEE	38.62	UniProtKB CARBOHYD
115	N-linked_Glycosylation	WHEWEIANNTFTGMW EEEEEECCCEECCEE	54.45	15532026
133	Phosphorylation	GDACRSRSRQSKVEL CHHHHHHCCCCHHHH	35.60	-
144	Ubiquitination	KVELACGKSNRLAHV HHHHHHCCCCCCCCC	44.43	29967540
207	Ubiquitination	ITPQGHEKLLRTLFE CCHHHHHHHHHHHHH	47.34	22817900
211	O-linked_Glycosylation	GHEKLLRTLFEDAGY HHHHHHHHHHHHCCC	35.45	OGP
223	Ubiquitination	AGYLKTPEENEPTQL CCCCCCCCCCCCCCC	77.88	22817900
228	O-linked_Glycosylation	TPEENEPTQLEGGPD CCCCCCCCCCCCCCC	39.34	OGP
253	Phosphorylation	RKAHKELSKEIKRLK HHHHHHHHHHHHHHH	29.36	-
271	O-linked_Glycosylation	TQHGIPYTRPTETSN HHCCCCCCCCCCCCC	25.48	55832741
274	O-linked_Glycosylation	GIPYTRPTETSNLEH CCCCCCCCCCCCCHH	48.91	55832747
276	O-linked_Glycosylation	PYTRPTETSNLEHLG CCCCCCCCCCCHHHC	25.95	55832753
277	O-linked_Glycosylation	YTRPTETSNLEHLGH CCCCCCCCCCHHHCC	32.93	55832759
286	O-linked_Glycosylation	LEHLGHETPRAKSPE CHHHCCCCCCCCCHH	16.64	55832763
291	O-linked_Glycosylation	HETPRAKSPEQLRGD CCCCCCCCHHHHCCC	32.46	55833755

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNPTG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNPTG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNPTG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPSB3_HUMAN	SPSB3	physical	28514442
GNPTA_HUMAN	GNPTAB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 252605: Mucolipidosis type III complementation group C (MLIIIC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.