CHSTA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHSTA_HUMAN
• UniProt AC: O43529
• Protein Name: Carbohydrate sulfotransferase 10
• Gene Name: CHST10
• Organism: Homo sapiens (Human).
• Sequence Length: 356
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis..
• Protein Sequence: MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDVYSAKQEFLFLTTMPEVRKLPEEKHIPEELKPTGKELPDSQLVQPLVYMERLELIRNVCRDDALKNLSHTPVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSDAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEIMYSVIGHHETLEDDAPYILKEAGIDHLVSYPTIPPGITVYNRTKVEHYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Ubiquitination	KFITLTFKDPDVYSA HHHHEECCCCCHHCC	64.22	33845483
45	O-linked_Glycosylation	KQEFLFLTTMPEVRK CCEEEEEECCHHHHC	17.45	OGP
66	Phosphorylation	IPEELKPTGKELPDS CCHHHCCCCCCCCHH	60.34	24719451
66	O-linked_Glycosylation	IPEELKPTGKELPDS CCHHHCCCCCCCCHH	60.34	55831019
81	Phosphorylation	QLVQPLVYMERLELI HCCHHHHHHHHHHHH	10.84	24719451
98	Ubiquitination	VCRDDALKNLSHTPV HCCHHHHHCCCCCCC	58.52	29967540
99	N-linked_Glycosylation	CRDDALKNLSHTPVS CCHHHHHCCCCCCCH	47.85	UniProtKB CARBOHYD
101	Phosphorylation	DDALKNLSHTPVSKF HHHHHCCCCCCCHHH	34.41	23532336
103	Phosphorylation	ALKNLSHTPVSKFVL HHHCCCCCCCHHHHH	23.24	23532336
128	Ubiquitination	ILFCQTPKVGNTQWK EEEECCCCCCCCCCE	67.19	-
177	Ubiquitination	FSDAEIQKRLKTYFK CCHHHHHHHHHHHHH	66.42	-
228	N-linked_Glycosylation	IIRKYRRNRTETRGI HHHHHHCCCCCCCCC	46.34	UniProtKB CARBOHYD
316	N-linked_Glycosylation	PPGITVYNRTKVEHY CCCEEEECCCCEEEE	40.59	UniProtKB CARBOHYD
328	Phosphorylation	EHYFLGISKRDIRRL EEEECCCCHHHHHHH	21.60	-
348	Phosphorylation	GDFKLFGYQKPDFLL CCEEECCCCCCCCCC	13.16	22817900
350	Ubiquitination	FKLFGYQKPDFLLN- EEECCCCCCCCCCC-	37.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHSTA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHSTA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHSTA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSF1_HUMAN	HSF1	physical	21988832
PON2_HUMAN	PON2	physical	26186194
PPM1A_HUMAN	PPM1A	physical	26186194
H6ST2_HUMAN	HS6ST2	physical	26186194
NPTX1_HUMAN	NPTX1	physical	26186194
PARL_HUMAN	PARL	physical	26186194
DPB1_HUMAN	HLA-DPB1	physical	26186194
SGPP1_HUMAN	SGPP1	physical	26186194
PARL_HUMAN	PARL	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
PON2_HUMAN	PON2	physical	28514442
PPM1A_HUMAN	PPM1A	physical	28514442
SGPP1_HUMAN	SGPP1	physical	28514442
S22AI_HUMAN	SLC22A18	physical	28514442
B4GA1_HUMAN	B4GAT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.