H6ST2_HUMAN - dbPTM
H6ST2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID H6ST2_HUMAN
UniProt AC Q96MM7
Protein Name Heparan-sulfate 6-O-sulfotransferase 2
Gene Name HS6ST2
Organism Homo sapiens (Human).
Sequence Length 605
Subcellular Localization Membrane
Single-pass type II membrane protein .
Protein Description 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate..
Protein Sequence MALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRGVSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNMDEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKTGGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRNFHYITILRDPVSRYLSEWRHVQRGATWKASLHVCDGRPPTSEELPSCYTGDDWSGCPLKEFMDCPYNLANNRQVRMLSDLTLVGCYNLSVMPEKQRNKVLLESAKSNLKHMAFFGLTEFQRKTQYLFEKTFNMNFISPFTQYNTTRASSVEINEEIQKRIEGLNFLDMELYSYAKDLFLQRYQFMRQKEHQEARRKRQEQRKFLKGRLLQTHFQSQGQGQSQNPNQNQSQNPNPNANQNLTQNLMQNLTQSLSQKENRESPKQNSGKEQNDNTSNGTNDYIGSVEKWR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
75PhosphorylationLDKPRKASSSLAGAA
CCCCCCCCHHHHHHH		24.40-
76PhosphorylationDKPRKASSSLAGAAC
CCCCCCCHHHHHHHH		33.94-
77PhosphorylationKPRKASSSLAGAACA
CCCCCCHHHHHHHHH		21.53-
135PhosphorylationHVLGAIFSKIFGPMA
HHHHHHHHHHHCCHH		20.8024719451
209N-linked_GlycosylationARFVPRYNFTRGDLL
CCCCCCCCCCCCHHH		32.85UniProtKB CARBOHYD
218MethylationTRGDLLRKVDFDIKG
CCCHHHCEECEECCC		46.23116253533
315PhosphorylationRDARLRPSRNFHYIT
CCCCCCCCCCCEEEE		33.1624719451
398PhosphorylationVRMLSDLTLVGCYNL
HEECCCCEEEEEEEC		25.12-
398O-linked_GlycosylationVRMLSDLTLVGCYNL
HEECCCCEEEEEEEC		25.1229237092
404N-linked_GlycosylationLTLVGCYNLSVMPEK
CEEEEEEECCCCCHH		29.89UniProtKB CARBOHYD
406PhosphorylationLVGCYNLSVMPEKQR
EEEEEECCCCCHHHH		16.8422210691
447PhosphorylationTQYLFEKTFNMNFIS
HHHHHHHHCCCCCCC		17.0324043423
454PhosphorylationTFNMNFISPFTQYNT
HCCCCCCCCCCCCCC		15.1524043423
457PhosphorylationMNFISPFTQYNTTRA
CCCCCCCCCCCCCCC		33.2624043423
459PhosphorylationFISPFTQYNTTRASS
CCCCCCCCCCCCCCH		16.0624043423
460N-linked_GlycosylationISPFTQYNTTRASSV
CCCCCCCCCCCCCHH		25.75UniProtKB CARBOHYD
461PhosphorylationSPFTQYNTTRASSVE
CCCCCCCCCCCCHHH		16.8424043423
462PhosphorylationPFTQYNTTRASSVEI
CCCCCCCCCCCHHHH		22.1724043423
528O-linked_GlycosylationLKGRLLQTHFQSQGQ
HHHHHHHHHHHCCCC		25.3255834579
544N-linked_GlycosylationQSQNPNQNQSQNPNP
CCCCCCCCCCCCCCC		50.54UniProtKB CARBOHYD
556N-linked_GlycosylationPNPNANQNLTQNLMQ
CCCCHHHHHHHHHHH		44.88UniProtKB CARBOHYD
564N-linked_GlycosylationLTQNLMQNLTQSLSQ
HHHHHHHHHHHHHHH		30.96UniProtKB CARBOHYD
577PhosphorylationSQKENRESPKQNSGK
HHHHHCCCCCCCCCC		33.8726091039
589N-linked_GlycosylationSGKEQNDNTSNGTND
CCCCCCCCCCCCCCC		53.62UniProtKB CARBOHYD
591PhosphorylationKEQNDNTSNGTNDYI
CCCCCCCCCCCCCCC		39.2425159151
592N-linked_GlycosylationEQNDNTSNGTNDYIG
CCCCCCCCCCCCCCC		60.31UniProtKB CARBOHYD
594PhosphorylationNDNTSNGTNDYIGSV
CCCCCCCCCCCCCCE		29.2121659604
597PhosphorylationTSNGTNDYIGSVEKW
CCCCCCCCCCCEECC		14.8428985074
600PhosphorylationGTNDYIGSVEKWR--
CCCCCCCCEECCC--		19.9721659604
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of H6ST2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of H6ST2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of H6ST2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of H6ST2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of H6ST2_HUMAN

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Related Literatures of Post-Translational Modification

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