| UniProt ID | B4GA1_HUMAN | |
|---|---|---|
| UniProt AC | O43505 | |
| Protein Name | Beta-1,4-glucuronyltransferase 1 {ECO:0000303|PubMed:25279697, ECO:0000303|PubMed:25279699, ECO:0000312|HGNC:HGNC:15685} | |
| Gene Name | B4GAT1 {ECO:0000303|PubMed:25279697, ECO:0000303|PubMed:25279699, ECO:0000312|HGNC:HGNC:15685} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 415 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein . Localizes near the trans-Golgi apparatus. |
|
| Protein Description | Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. [PubMed: 25279699] | |
| Protein Sequence | MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVKAQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAGFDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | S-palmitoylation | QMSYAIRCAFYQLLL CHHHHHHHHHHHHHH | 29575903 | ||
| 60 | Ubiquitination | PRSVDQVKAQLRTAL CCCHHHHHHHHHHHH | - | ||
| 65 | Phosphorylation | QVKAQLRTALASGGV HHHHHHHHHHHHCCC | - | ||
| 65 | O-linked_Glycosylation | QVKAQLRTALASGGV HHHHHHHHHHHHCCC | OGP | ||
| 69 | Phosphorylation | QLRTALASGGVLDAS HHHHHHHHCCCCCCC | - | ||
| 188 | Ubiquitination | SCQEVFDKLARVAQP HHHHHHHHHHHHHCC | - | ||
| 204 | N-linked_Glycosylation | INYALGTNVSYPNNL CCHHCCCCCCCCCHH | UniProtKB CARBOHYD | ||
| 253 | O-linked_Glycosylation | QSNQWGGTALVVPAF HCCCCCCEEEEEEHH | OGP | ||
| 300 | N-linked_Glycosylation | TPCQAPTNYSRWVNL CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 377 | Ubiquitination | FLVHKGFKEALKFHP EEEECCHHHHHHHCC | - | ||
| 386 | Ubiquitination | ALKFHPQKEAENQHN HHHHCCCHHHHHHHH | - | ||
| 394 | Ubiquitination | EAENQHNKILYRQFK HHHHHHHHHHHHHHH | - | ||
| 411 | Phosphorylation | LKAKYPNSPRRC--- HHHHCCCCCCCC--- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of B4GA1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of B4GA1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of B4GA1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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