HPLN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPLN3_HUMAN
• UniProt AC: Q96S86
• Protein Name: Hyaluronan and proteoglycan link protein 3
• Gene Name: HAPLN3
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: May function in hyaluronic acid binding..
• Protein Sequence: MGLLLLVPLLLLPGSYGLPFYNGFYYSNSANDQNLGNGHGKDLLNGVKLVVETPEETLFTYQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVHLRQDKEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAPGVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPDPQSRLYGVYCYRQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Phosphorylation	QDKEHDVSLEIQDLR CCCCCCEEEEEECCC	26.75	25850435
172	Phosphorylation	GVVFPYQSPNGRYQF EEEEEEECCCCCEEE	17.94	30257219
177	Phosphorylation	YQSPNGRYQFNFHEG EECCCCCEEEECCCC	20.89	24043423
192	Phosphorylation	QQVCAEQAAVVASFE CEEHHHHHHHHHCHH	8.17	-
197	Phosphorylation	EQAAVVASFEQLFRA HHHHHHHCHHHHHHH	20.08	24043423
255	Phosphorylation	RHRRLHRYDVFCFAT CCCCCCCCCHHHHHH	13.00	21712546
262	Phosphorylation	YDVFCFATALKGRVY CCHHHHHHHHCCCEE	16.57	21712546
317	Phosphorylation	RCDAGWLADGSVRYP CCCCCEECCCEEEEC	16.77	-
324	Phosphorylation	ADGSVRYPVVHPHPN CCCEEEECEECCCCC	15.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPLN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPLN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPLN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHAC2_HUMAN	CHAC2	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
ARMC8_HUMAN	ARMC8	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.