FKTN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FKTN_HUMAN
• UniProt AC: O75072
• Protein Name: Fukutin
• Gene Name: FKTN
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. [PubMed: 17034757 May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development.]
• Protein Sequence: MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSTKNGAGLSKSKGSRIGFDSTQWRAVKKFIMLTSNQNVPVFLIDPLILELINKNFEQVKNTSHGSTSQCKFFCVPRDFTAFALQYHLWKNEEGWFRIAENMGFQCLKIESKDPRLDGIDSLSGTEIPLHYICKLATHAIHLVVFHERSGNYLWHGHLRLKEHIDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLEVLIPKDPMHFVEEVPHSRFIECRYKEARAFFQQYLDDNTVEAVAFRKSAKELLQLAAKTLNKLGVPFWLSSGTCLGWYRQCNIIPYSKDVDLGIFIQDYKSDIILAFQDAGLPLKHKFGKVEDSLELSFQGKDDVKLDVFFFYEETDHMWNGGTQAKTGKKFKYLFPKFTLCWTEFVDMKVHVPCETLEYIEANYGKTWKIPVKTWDWKRSPPNVQPNGIWPISEWDEVIQLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	QLYYYKHYLSTKNGA HHHHHHHHHHCCCCC	9.74	-
33	Phosphorylation	YYYKHYLSTKNGAGL HHHHHHHHCCCCCCC	30.12	-
92	N-linked_Glycosylation	KNFEQVKNTSHGSTS CCHHHHCCCCCCCCC	48.21	UniProtKB CARBOHYD
276	Phosphorylation	EAVAFRKSAKELLQL HHHHHHHHHHHHHHH	40.07	-
328	Acetylation	GIFIQDYKSDIILAF EEEEEECCCCEEEEE	50.36	7378473
352	Phosphorylation	KFGKVEDSLELSFQG CCCCCCCEEEEEECC	15.39	-
408	"N6,N6-dimethyllysine"	WTEFVDMKVHVPCET EEEECCCEEECCHHH	25.40	-
408	Methylation	WTEFVDMKVHVPCET EEEECCCEEECCHHH	25.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FKTN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FKTN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FKTN_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FKTN_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.