TM39B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM39B_HUMAN
• UniProt AC: Q9GZU3
• Protein Name: Transmembrane protein 39B
• Gene Name: TMEM39B
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MGGRRGPNRTSYCRNPLCEPGSSGGSSGSHTSSASVTSVRSRTRSSSGTGLSSPPLATQTVVPLQHCKIPELPVQASILFELQLFFCQLIALFVHYINIYKTVWWYPPSHPPSHTSLNFHLIDFNLLMVTTIVLGRRFIGSIVKEASQRGKVSLFRSILLFLTRFTVLTATGWSLCRSLIHLFRTYSFLNLLFLCYPFGMYIPFLQLNCDLRKTSLFNHMASMGPREAVSGLAKSRDYLLTLRETWKQHTRQLYGPDAMPTHACCLSPSLIRSEVEFLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKNTHYYDKRWSCELFLLVSISTSVILMQHLLPASYCDLLHKAAAHLGCWQKVDPALCSNVLQHPWTEECMWPQGVLVKHSKNVYKAVGHYNVAIPSDVSHFRFHFFFSKPLRILNILLLLEGAVIVYQLYSLMSSEKWHQTISLALILFSNYYAFFKLLRDRLVLGKAYSYSASPQRDLDHRFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	N-linked_Glycosylation	MGGRRGPNRTSYCRN CCCCCCCCCCCCCCC	63.79	UniProtKB CARBOHYD
10	Phosphorylation	GRRGPNRTSYCRNPL CCCCCCCCCCCCCCC	30.59	-
14	Ubiquitination	PNRTSYCRNPLCEPG CCCCCCCCCCCCCCC	39.30	-
22	Phosphorylation	NPLCEPGSSGGSSGS CCCCCCCCCCCCCCC	36.20	21712546
23	Phosphorylation	PLCEPGSSGGSSGSH CCCCCCCCCCCCCCC	53.76	21712546
26	Phosphorylation	EPGSSGGSSGSHTSS CCCCCCCCCCCCCCC	34.74	30576142
31	Phosphorylation	GGSSGSHTSSASVTS CCCCCCCCCCCEEEE	26.52	-
35	Ubiquitination	GSHTSSASVTSVRSR CCCCCCCEEEEECCC	28.07	-
37	Phosphorylation	HTSSASVTSVRSRTR CCCCCEEEEECCCCC	21.00	30576142
43	Phosphorylation	VTSVRSRTRSSSGTG EEEECCCCCCCCCCC	35.83	28857561
45	Phosphorylation	SVRSRTRSSSGTGLS EECCCCCCCCCCCCC	28.39	23927012
46	Phosphorylation	VRSRTRSSSGTGLSS ECCCCCCCCCCCCCC	29.51	23927012
47	Phosphorylation	RSRTRSSSGTGLSSP CCCCCCCCCCCCCCC	41.44	23927012
49	Phosphorylation	RTRSSSGTGLSSPPL CCCCCCCCCCCCCCC	36.58	23927012
52	Phosphorylation	SSSGTGLSSPPLATQ CCCCCCCCCCCCCCC	41.99	23663014
53	Phosphorylation	SSGTGLSSPPLATQT CCCCCCCCCCCCCCE	35.26	23663014
58	Phosphorylation	LSSPPLATQTVVPLQ CCCCCCCCCEEEECC	32.24	23663014
60	Phosphorylation	SPPLATQTVVPLQHC CCCCCCCEEEECCCC	21.08	23663014
201	Phosphorylation	LCYPFGMYIPFLQLN HHHHHHHHHHHHHCC	13.06	-
213	Ubiquitination	QLNCDLRKTSLFNHM HCCCCCCCCHHHHHH	50.16	-
234	Ubiquitination	EAVSGLAKSRDYLLT HHHHHHHHCHHHHHH	51.58	-
276	Ubiquitination	SLIRSEVEFLKMDFN HHHHHHHHHHHCCCC	41.01	-
293	Phosphorylation	MKEVLVSSMLSAYYV HHHHHHHHHHHHHHH	19.10	-
296	Phosphorylation	VLVSSMLSAYYVAFV HHHHHHHHHHHHHHE	12.94	-
327	Phosphorylation	CELFLLVSISTSVIL EEEHHHHHHHHHHHH	15.70	-
329	Phosphorylation	LFLLVSISTSVILMQ EHHHHHHHHHHHHHH	13.71	-
331	Phosphorylation	LLVSISTSVILMQHL HHHHHHHHHHHHHHH	10.60	-
348	Ubiquitination	ASYCDLLHKAAAHLG HHHHHHHHHHHHHCC	25.63	21890473
416	Phosphorylation	FRFHFFFSKPLRILN EEEEHHCCCHHHHHH	28.36	24719451
449	Phosphorylation	SSEKWHQTISLALIL CCHHHHHHHHHHHHH	10.31	26552605
451	Phosphorylation	EKWHQTISLALILFS HHHHHHHHHHHHHHH	15.81	26552605
458	Phosphorylation	SLALILFSNYYAFFK HHHHHHHHHHHHHHH	22.07	26552605
460	Phosphorylation	ALILFSNYYAFFKLL HHHHHHHHHHHHHHH	8.58	26552605
461	Phosphorylation	LILFSNYYAFFKLLR HHHHHHHHHHHHHHH	10.94	26552605
475	Ubiquitination	RDRLVLGKAYSYSAS HHHHHHCCEECCCCC	39.73	21890473
482	Phosphorylation	KAYSYSASPQRDLDH CEECCCCCCCCCCCC	18.67	25159151
492	Phosphorylation	RDLDHRFS------- CCCCCCCC-------	38.99	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM39B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM39B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM39B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM39B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.