SNX25_HUMAN - dbPTM
SNX25_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNX25_HUMAN
UniProt AC Q9H3E2
Protein Name Sorting nexin-25
Gene Name SNX25
Organism Homo sapiens (Human).
Sequence Length 840
Subcellular Localization Endosome membrane
Peripheral membrane protein . Detected in endosome-derived secreted vesicles (exosomes) from malignant pleural effusions.
Protein Description May be involved in several stages of intracellular trafficking..
Protein Sequence MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIARQLHHRLSHVDVVKVVCNDVVRTLLTHFCDLKAANARHEEQPRPFVLHACLRNSDDEVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLLAQLAYREQMNEHHKRAYTYAPSYEDFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTDWWCENLGMWKASITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEETEEDSDLSDYGDDVDGRKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWIFSEQMLVYYINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIPDMLQSLVGQQNARHGIIKIFNALQETRANKHLLYALMELLLIELCPELRVHLDQLKAGQV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationLKEVFDYSYRDYILS
HHHHHCCHHHHHHHH		18.6124719451
16PhosphorylationFDYSYRDYILSWYGN
HCCHHHHHHHHHHCC		8.51-
19PhosphorylationSYRDYILSWYGNLSR
HHHHHHHHHHCCCCC		14.5327050516
21PhosphorylationRDYILSWYGNLSRDE
HHHHHHHHCCCCCCC		7.86-
25PhosphorylationLSWYGNLSRDEGQLY
HHHHCCCCCCCCHHH		41.50-
43UbiquitinationLEDFWEIARQLHHRL
HHHHHHHHHHHHHHH		5.0121890473
66PhosphorylationVCNDVVRTLLTHFCD
HHHHHHHHHHHHHHC		17.9522468782
69PhosphorylationDVVRTLLTHFCDLKA
HHHHHHHHHHHCHHH		18.93-
118PhosphorylationLVFCLLPSKDVQSLS
HHHHHCCCCCHHHHH		41.2724719451
123PhosphorylationLPSKDVQSLSLRIML
CCCCCHHHHHHHHHH		21.5517081983
125PhosphorylationSKDVQSLSLRIMLAE
CCCHHHHHHHHHHHH		22.3517081983
135PhosphorylationIMLAEILTTKVLKPV
HHHHHHHHHHHHHHH		30.17-
136PhosphorylationMLAEILTTKVLKPVV
HHHHHHHHHHHHHHH		18.73-
162PhosphorylationMLLAQLAYREQMNEH
HHHHHHHHHHHHHHH		24.23-
197UbiquitinationNSDVEFLKQLRYQIV
CCCHHHHHHHCHHHH		53.2421890473
243PhosphorylationRARNMKRYINQLTVA
HHHHHHHHHHHHHHH		9.94-
361UbiquitinationSLYKEIQQCLVGNKG
HHHHHHHHHHCCCCC		28.3321890473
410PhosphorylationKEEEKHASQMISNKD
HHHHHHHHHHHCCCC		21.7218077418
554PhosphorylationWTVPRRLSEFQNLHR
CCCCCCHHHHHHHHH		34.2630108239
577PhosphorylationLKKVQLPSLSKLPFK
CCCCCCCCCCCCCCC		54.5929449344
579PhosphorylationKVQLPSLSKLPFKSI
CCCCCCCCCCCCCCC		36.1622985185
584AcetylationSLSKLPFKSIDQKFM
CCCCCCCCCCCHHHH		44.5620167786
589AcetylationPFKSIDQKFMEKSKN
CCCCCCHHHHHHHHH		42.827705955
593AcetylationIDQKFMEKSKNQLNK
CCHHHHHHHHHHHHH		55.757493333
639PhosphorylationDVQGKKNSFSLSSFL
ECCCCCCCCCHHHHH		25.7030108239
641PhosphorylationQGKKNSFSLSSFLER
CCCCCCCCHHHHHHH		27.4530108239
665PhosphorylationEEETEEDSDLSDYGD
CCCCCCCCCHHHCCC		43.6720363803
668PhosphorylationTEEDSDLSDYGDDVD
CCCCCCHHHCCCCCC		33.5020363803
670PhosphorylationEDSDLSDYGDDVDGR
CCCCHHHCCCCCCCC		21.0523909892
725PhosphorylationINKQIRDTVSWIFSE
CCHHHHHHHHHHHCH		13.4425907765
727PhosphorylationKQIRDTVSWIFSEQM
HHHHHHHHHHHCHHH		19.2925907765
731PhosphorylationDTVSWIFSEQMLVYY
HHHHHHHCHHHHHHH		20.1325907765
737PhosphorylationFSEQMLVYYINIFRD
HCHHHHHHHHHHCCC		8.4825907765
738PhosphorylationSEQMLVYYINIFRDA
CHHHHHHHHHHCCCC		4.6825907765
764PhosphorylationTIRSKEQSQETKQRA
CCCCHHHHHHHHHHH		30.95-
785PhosphorylationNIPDMLQSLVGQQNA
CHHHHHHHHHCCHHH		22.5127174698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNX25_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNX25_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNX25_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SNX25_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNX25_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665 AND SER-668, ANDMASS SPECTROMETRY.

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