S47A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S47A1_HUMAN
• UniProt AC: Q96FL8
• Protein Name: Multidrug and toxin extrusion protein 1
• Gene Name: SLC47A1
• Organism: Homo sapiens (Human).
• Sequence Length: 570
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Predominantly localized at the plasma membrane but also found in intracellular organelles.
• Protein Description: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes..
• Protein Sequence: MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAPEEPA -------CCCCCCCC	10.01	22814378
17	Phosphorylation	VRGGPEATLEVRGSR CCCCCCCEEEECHHH	23.07	26434552
23	Phosphorylation	ATLEVRGSRCLRLSA CEEEECHHHHEEHHH	14.84	26434552
29	Phosphorylation	GSRCLRLSAFREELR HHHHEEHHHHHHHHH	20.94	24719451
258	Phosphorylation	ECLQDWASFLRLAIP HHHHHHHHHHHHHHH	22.14	24719451
476	Ubiquitination	AQVHANLKVNNVPRS CCCCCCCEECCCCCC	42.60	29967540
536	Ubiquitination	EHPQDGAKLSRKQLV CCCCCCCCCCHHHHH	53.15	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S47A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S47A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S47A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPM2_HUMAN	TPM2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.