FACR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FACR2_HUMAN
• UniProt AC: Q96K12
• Protein Name: Fatty acyl-CoA reductase 2 {ECO:0000305|PubMed:15220348}
• Gene Name: FAR2 {ECO:0000312|HGNC:HGNC:25531}
• Organism: Homo sapiens (Human).
• Sequence Length: 515
• Subcellular Localization: Peroxisome membrane ; Single-pass membrane protein .
• Protein Description: Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. [PubMed: 15220348 It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity]
• Protein Sequence: MSTIAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFEKVKEVCPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQLNVTATRQLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKLIRDWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGFLRAIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRPKSTLVYHITSGNMNPCNWHKMGVQVLATFEKIPFERPFRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRLLRTVSMLEYFINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDMAGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVWFFIVSFCYKFLSYFRASSTLKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTIAAFYG ------CCCEEHHHC	28.64	27762562
3	Phosphorylation	-----MSTIAAFYGG -----CCCEEHHHCC	17.21	28122231
8	Phosphorylation	MSTIAAFYGGKSILI CCCEEHHHCCEEEEE	21.90	28122231
12	Phosphorylation	AAFYGGKSILITGAT EHHHCCEEEEEECCC	26.38	28122231
16	Phosphorylation	GGKSILITGATGFLG CCEEEEEECCCCHHH	19.81	28122231
19	Phosphorylation	SILITGATGFLGKVL EEEEECCCCHHHHHH	29.79	28555341
29	Ubiquitination	LGKVLMEKLFRTSPD HHHHHHHHHHCCCCC	38.67	-
63	Ubiquitination	VFQILDSKLFEKVKE HHHHHCHHHHHHHHH	57.79	21890473
230	Phosphorylation	NIAIIRPSIVGATWQ CEEEECHHHCCCCCC	21.76	24719451
235	Phosphorylation	RPSIVGATWQEPFPG CHHHCCCCCCCCCCC	23.04	24719451
257	Phosphorylation	PNGIIIATGKGFLRA CCEEEEEECHHHHHH	29.08	24719451
282	Ubiquitination	VIPVDTVVNLMLAVG CCCHHHHHHHHHHHC	5.03	-
351	Phosphorylation	SNSFTSQYWNAVSHR CCCHHHHHHHHHCCC	10.61	22817900
364	Phosphorylation	HRAPAIIYDCYLRLT CCCCHHHHHHHHHHH	8.21	22817900
367	Phosphorylation	PAIIYDCYLRLTGRK CHHHHHHHHHHHCCC	7.61	22817900
379	Ubiquitination	GRKPRMTKLMNRLLR CCCHHHHHHHHHHHH	36.07	21890473
387	Phosphorylation	LMNRLLRTVSMLEYF HHHHHHHHHHHHHHH	19.53	22210691
389	Phosphorylation	NRLLRTVSMLEYFIN HHHHHHHHHHHHHHH	19.62	22210691
406	Phosphorylation	WEWSTYNTEMLMSEL CCCCCCCHHHHHHCC	16.62	22210691
447	Ubiquitination	GVKKYLLKEDMAGIP HHHHHHCHHHHCCCH	49.42	-
468	Phosphorylation	KRLRNIHYLFNTALF HHHHHHHHHHHHHHH	14.80	22210691
472	Phosphorylation	NIHYLFNTALFLIAW HHHHHHHHHHHHHHH	19.87	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FACR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FACR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FACR2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FACR2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.