LPCT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LPCT4_HUMAN
• UniProt AC: Q643R3
• Protein Name: Lysophospholipid acyltransferase LPCAT4
• Gene Name: LPCAT4
• Organism: Homo sapiens (Human).
• Sequence Length: 524
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors..
• Protein Sequence: MSQGSPGDWAPLDPTPGPPASPNPFVHELHLSRLQRVKFCLLGALLAPIRVLLAFIVLFLLWPFAWLQVAGLSEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGLSAGYVDAGAEPGRSRMISQEEFARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQAEGPNRLLYKDGFSTILHLLLGSPHPAATALHAELCQAGSSQGLSLCQFQNFSLHDPLYGKLFSTYLRPPHTSRGTSQTPNASSPGNPTALANGTVQAPKQKGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQGSPGDW ------CCCCCCCCC	43.16	18691976
5	Phosphorylation	---MSQGSPGDWAPL ---CCCCCCCCCCCC	20.33	25159151
97	Phosphorylation	HNGVLGLSRLLFFLL CCCHHHHHHHHHHHH	21.05	46160553
145	Ubiquitination	LLPCDLPKVVSRAEN EEECCHHHHHCHHHC	63.67	-
152	N-linked_Glycosylation	KVVSRAENLSVPVIG HHHCHHHCCCHHHHH	36.31	UniProtKB CARBOHYD
163	Ubiquitination	PVIGALLRFNQAILV HHHHHHHHHCCEEEE	29.35	22817900
167	Ubiquitination	ALLRFNQAILVSRHD HHHHHCCEEEECCCC	9.74	22817900
216	Ubiquitination	KKALLKFKPGAFIAG CHHHHHCCCCCEECC	40.74	-
319	Ubiquitination	VIVVGRLKVALEPQL EEEECCCEEECCHHH	24.89	-
331	Ubiquitination	PQLWELGKVLRKAGL HHHHHHHHHHHHCCC	51.20	22817900
335 (in isoform 1)	Ubiquitination	-	42.52	21906983
335	Ubiquitination	ELGKVLRKAGLSAGY HHHHHHHHCCCCCCC	42.52	22817900
354	Sulfoxidation	AEPGRSRMISQEEFA CCCCCCCCCCHHHHH	3.49	21406390
496	Phosphorylation	PPHTSRGTSQTPNAS CCCCCCCCCCCCCCC	19.29	63756869
497	Phosphorylation	PHTSRGTSQTPNASS CCCCCCCCCCCCCCC	34.58	63714489
499	Phosphorylation	TSRGTSQTPNASSPG CCCCCCCCCCCCCCC	20.48	63718237
503	Phosphorylation	TSQTPNASSPGNPTA CCCCCCCCCCCCCCC	43.64	18691976
504	Phosphorylation	SQTPNASSPGNPTAL CCCCCCCCCCCCCCC	34.12	21815630
509	Phosphorylation	ASSPGNPTALANGTV CCCCCCCCCCCCCCC	38.00	29052541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LPCT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LPCT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LPCT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPG7_HUMAN	SPG7	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
UBP33_HUMAN	USP33	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.