HTRA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HTRA3_HUMAN
• UniProt AC: P83110
• Protein Name: Serine protease HTRA3
• Gene Name: HTRA3
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Subcellular Localization: Secreted . Secretion increased during decidualization of endometrial stromal cells.
• Protein Description: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. [PubMed: 21321049]
• Protein Sequence: MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Phosphorylation	PLGLHQLSSPRYKFN CCCCCCCCCCCHHHH	31.55	17081983
135	Phosphorylation	LGLHQLSSPRYKFNF CCCCCCCCCCHHHHH	23.22	17081983
214	Phosphorylation	VQLQNGDSYEATIKD EEECCCCCEEEEECC	26.69	27251275
334	Phosphorylation	GISFAIPSDRITRFL EEEEEECHHHHHHHH	33.15	-
363	Phosphorylation	FIGIRMRTITPSLVD HHEEEEEEECHHHHH	21.62	29449344
365	Phosphorylation	GIRMRTITPSLVDEL EEEEEEECHHHHHHH	13.25	29449344
367	Phosphorylation	RMRTITPSLVDELKA EEEEECHHHHHHHHH	32.16	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HTRA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HTRA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HTRA3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HTRA3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.