| UniProt ID | FUZZY_HUMAN | |
|---|---|---|
| UniProt AC | Q9BT04 | |
| Protein Name | Protein fuzzy homolog | |
| Gene Name | FUZ | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 418 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, cilium basal body . | |
| Protein Description | Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).. | |
| Protein Sequence | MGEEGTGGTVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHDSITLIVLSSEVGISELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCGPSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKEPSPEQRRRLLRNFYTLVTSTHFPPEPGPPEKTEDEVYQAQLPRACYLVLGTEEPGTGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTPLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | Phosphorylation | NTTVVWKSFHDSITL CEEEEEEEECCEEEE | 16.47 | - | |
| 80 | Phosphorylation | KSFHDSITLIVLSSE EEECCEEEEEEEECC | 17.87 | - | |
| 85 | Phosphorylation | SITLIVLSSEVGISE EEEEEEEECCCCCCH | 17.35 | - | |
| 91 | Phosphorylation | LSSEVGISELRLERL EECCCCCCHHHHHHH | 25.34 | 24719451 | |
| 191 | O-linked_Glycosylation | SGRVVAATEGWWRLG CCEEEEECCCCHHCC | 25.87 | 29351928 | |
| 319 | Ubiquitination | TVEPLGDKEPSPEQR CCCCCCCCCCCHHHH | 70.49 | - | |
| 351 | Ubiquitination | PEPGPPEKTEDEVYQ CCCCCCCCCCCHHHH | 64.09 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FUZZY_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FUZZY_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FUZZY_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| INTU_HUMAN | INTU | physical | 28514442 | |
| OSBL9_HUMAN | OSBPL9 | physical | 28514442 | |
| HPS1_HUMAN | HPS1 | physical | 28514442 | |
| OSB11_HUMAN | OSBPL11 | physical | 28514442 | |
| UBB_HUMAN | UBB | physical | 28514442 | |
| DDX11_HUMAN | DDX11 | physical | 28514442 | |
| HSP7C_HUMAN | HSPA8 | physical | 28514442 | |
| UBE3A_HUMAN | UBE3A | physical | 28514442 | |
| BAG6_HUMAN | BAG6 | physical | 28514442 | |
| ARP6_HUMAN | ACTR6 | physical | 28514442 | |
| PGES2_HUMAN | PTGES2 | physical | 28514442 | |
| CND3_HUMAN | NCAPG | physical | 28514442 | |
| GET4_HUMAN | GET4 | physical | 28514442 | |
| UBR4_HUMAN | UBR4 | physical | 28514442 | |
| ESPL1_HUMAN | ESPL1 | physical | 28514442 | |
| VP13B_HUMAN | VPS13B | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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