HTRA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HTRA1_HUMAN
• UniProt AC: Q92743
• Protein Name: Serine protease HTRA1
• Gene Name: HTRA1
• Organism: Homo sapiens (Human).
• Sequence Length: 480
• Subcellular Localization: Cell membrane . Secreted . Cytoplasm, cytosol . Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635).
• Protein Description: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets..
• Protein Sequence: MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
195	Phosphorylation	LFRKLPFSKREVPVA HHHCCCCCCCCCCCC	28.94	-
237	Phosphorylation	VELKNGATYEAKIKD EEECCCCEEEEEECC	24.24	-
238	Phosphorylation	ELKNGATYEAKIKDV EECCCCEEEEEECCC	17.23	-
305	Ubiquitination	STTQRGGKELGLRNS EECCCCCEEECCCCC	53.22	-
357	Phosphorylation	GISFAIPSDKIKKFL EEEEEECHHHHHHHH	45.48	-
365	Phosphorylation	DKIKKFLTESHDRQA HHHHHHHHHHCCHHH	38.28	-
367	Phosphorylation	IKKFLTESHDRQAKG HHHHHHHHCCHHHCC	26.00	-
382	Phosphorylation	KAITKKKYIGIRMMS CCCCHHHCEEEEEEE	17.17	23403867
393	Phosphorylation	RMMSLTSSKAKELKD EEEECCCHHHHHHHH	31.25	23403867
444	Phosphorylation	INGQSVVSANDVSDV ECCEEEEECHHHHHH	21.14	30576142
449	Phosphorylation	VVSANDVSDVIKRES EEECHHHHHHHHCHH	29.08	30576142
456	Phosphorylation	SDVIKRESTLNMVVR HHHHHCHHHHHHHEE	42.08	-
472	Phosphorylation	GNEDIMITVIPEEID CCCCEEEEECCCCCC	8.59	30243723

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HTRA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HTRA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HTRA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XIAP_HUMAN	XIAP	physical	21387310
IMDH1_HUMAN	IMPDH1	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.