dbPTM

CHD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHD6_HUMAN
UniProt AC	Q8TD26
Protein Name	Chromodomain-helicase-DNA-binding protein 6
Gene Name	CHD6
Organism	Homo sapiens (Human).
Sequence Length	2715
Subcellular Localization	Nucleus, nucleoplasm . Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin.
Protein Description	DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. [PubMed: 28533432 Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.; (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.]
Protein Sequence	MKMKIQKKEKQLSNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQEEKIEDVASHCLPQKDLYTAEEEAATLFPRKMTSHNGMEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKRKREPKEPKEPRKAKEPKKAKEHKEPKQKDGAKKARKPREASGTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVESLELDQGLTNPSLRSPEESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDDANIIEKILASKTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKDPRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYVEVDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEEDVDPAKVKEFESLQVLPEIKHVERPASDSWQKLEKSREYKNSNQLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLRGIHGPFLIIAPLSTITNWEREFRTWTEMNAIVYHGSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGGTNGVQQLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKIAELDTEAKNEKESLVIDRPRVRKQTKHYNSFEEDELMEFSELDSDSDERPTRSRRLNDKARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVYCVKHYKGDEKIKSFIWELITPTKDGQAQTLQNHSGLSAPVPRGRKGKKTKNQLLIPELKDADWLATCNPEVVLHDDGYKKHLKQHCNKVLLRVRMLYYLKAEILGEAAEKAFEGSPARELDVPLPDIDYMEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSLSAEQGVTDGTSDIPERGNTDKEDNAEDKVDGLQKQTESSSDGGDGVFSEKKDDSRAAQDGSDPDKSPWPVSSALTARLRRLVTVYQRCNRKELCRPEILGPGNQGYWVQEEMFRRTSEMDLINKEAQKRWTRREQADFYRTVSSFGVVYDQEKKTFDWTQFRIISRLDKKSDESLEQYFYSFVAMCRNVCRLPTWKDGGPPDTTIYVEPITEERAARTLYRIELLRKVREQVLKCPQLHERLQLCRPSLYLPVWWECGKHDRDLLIGTAKHGLNRTDCYIMNDPQLSFLDAYRNYAQHKRSGTQAPGNLCCLYQTNSKLYESLTYSQMSRTSESLENEPENLVRVESRDDHLSLPDVTCENFISKVQDVISINHDESLLPESLESMMYGKKVLSQEPSSFQESPSTNTESRKDVITISISKDGNCQSGGPEAEIASGPTFMGSLEAGGVAQANIKNGKHLLMSISKEGELCCSEAGQRPENIGQLEAKCLASPSLNPGNESGFVDMCSLSVCDSKRNLSSDQQLIDLLENKSLESKLILSQNHSDEEEEEEENEEENLAMAVGMGERPEVLHLTEPTTNISREKNQGFQDETKKGSLEVANQTPGLQRAFPAPAACQCHCKHMERWMHGLENDEFEIEKPKAYIPDLFKSKTNTIAMEGEPTAIPSQPFKVKHELLKEPWKESAEGQNVFPTYPLEGSELKSEDMDFENKDDYDRDGNCHSQDYPGKYSEEESKSSTSGITGDIGDELQEARAPTIAQLLQEKTLYSFSEWPKDRVIINRLDNICHVVLKGKWPSSQQYEPSGTLPTPVLTSSAGSRTSLSEPEAAEHSFSNGAALAAQIHKESFLAPVFTKDEQKHRRPYEFEVERDAKARGLEQFSATHGHTPIILNGWHGESAMDLSCSSEGSPGATSPFPVSASTPKIGAISSLQGALGMDLSGILQAGLIHPVTGQIVNGSLRRDDAATRRRRGRRKHVEGGMDLIFLKEQTLQAGILEVHEDPGQATLSTTHPEGPGPATSAPEPATAASSQAEKSIPSKSLLDWLRQQADYSLEVPGFGANFSDKPKQRRPRCKEPGKLDVSSLSGEERVPAIPKEPGLRGFLPENKFNHTLAEPILRDTGPRRRGRRPRSELLKAPSIVADSPSGMGPLFMNGLIAGMDLVGLQNMRNMPGIPLTGLVGFPAGFATMPTGEEVKSTLSMLPMMLPGMAAVPQMFGVGGLLSPPMATTCTSTAPASLSSTTKSGTAVTEKTAEDKPSSHDVKTDTLAEDKPGPGPFSDQSEPAITTSSPVAFNPFLIPGVSPGLIYPSMFLSPGMGMALPAMQQARHSEIVGLESQKRKKKKTKGDNPNSHPEPAPSCEREPSGDENCAEPSAPLPAEREHGAQAGEGALKDSNNDTN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	MKIQKKEKQLSNLKV CCCCHHHHHHHCCEE	66.47	25953088
21	Phosphorylation	NLKVLNHSPMSDASV CCEECCCCCCCCCCC	22.64	25159151
24	Phosphorylation	VLNHSPMSDASVNFD ECCCCCCCCCCCCCC	33.15	25159151
27	Phosphorylation	HSPMSDASVNFDYKS CCCCCCCCCCCCCCC	23.68	25159151
34	Phosphorylation	SVNFDYKSPSPFDCS CCCCCCCCCCCCCCC	25.12	30266825
36	Phosphorylation	NFDYKSPSPFDCSTD CCCCCCCCCCCCCCC	45.34	30266825
40 (in isoform 2)	Phosphorylation	-	4.89	30631047
41	Phosphorylation	SPSPFDCSTDQEEKI CCCCCCCCCCHHHHH	36.54	30266825
41 (in isoform 2)	Phosphorylation	-	36.54	30631047
42	Phosphorylation	PSPFDCSTDQEEKIE CCCCCCCCCHHHHHH	48.29	30266825
53	Phosphorylation	EKIEDVASHCLPQKD HHHHHHHHHHCCHHH	18.00	17924679
77	Phosphorylation	TLFPRKMTSHNGMED HHCCCCCCCCCCCCC	29.84	21406692
78	Phosphorylation	LFPRKMTSHNGMEDS HCCCCCCCCCCCCCC	16.08	21406692
85	Phosphorylation	SHNGMEDSGGGGTGV CCCCCCCCCCCCCCC	26.49	25159151
90	Phosphorylation	EDSGGGGTGVKKKRK CCCCCCCCCCCCCCC	41.92	21406692
111	Phosphorylation	QEGAAKGSKDREPKP HHHHHCCCCCCCCCC	30.58	-
134	Ubiquitination	PKEPRKAKEPKKAKE CCCCCCCCCCHHHHH	77.05	-
138	Ubiquitination	RKAKEPKKAKEHKEP CCCCCCHHHHHCCCC	75.34	-
183	Acetylation	AARTKSRKASKEQGP HHHHHHHHHHHHHCC	65.19	19821051
185	Phosphorylation	RTKSRKASKEQGPTP HHHHHHHHHHHCCCC	39.50	24719451
186	Acetylation	TKSRKASKEQGPTPV HHHHHHHHHHCCCCC	59.94	20167786
191	Phosphorylation	ASKEQGPTPVEKKKK HHHHHCCCCCHHCCC	46.95	21815630
198	Acetylation	TPVEKKKKGKRKSET CCCHHCCCCCCCCCC	77.78	90741
262	Phosphorylation	VVDDDGETIAVLGAG EECCCCCEEEEECCC	21.55	-
296	Ubiquitination	DDANIIEKILASKTV CCCHHHHHHHHCCCC	32.39	29967540
301	Ubiquitination	IEKILASKTVQEVHP HHHHHHCCCCCCCCC	47.29	29967540
327	Phosphorylation	VKYRNFSYLHCKWAT EEECCCEEEEEEEEC	9.05	-
334	Phosphorylation	YLHCKWATMEELEKD EEEEEEECHHHHHHC	24.81	-
340	Acetylation	ATMEELEKDPRIAQK ECHHHHHHCHHHHHH	82.65	12649973
374	Phosphorylation	EDLFNPDYVEVDRIL HHHCCCCCEEHHHHH	10.36	27642862
424	Ubiquitination	DVDPAKVKEFESLQV CCCHHHHHHHHHHCC	56.85	29967540
436	Ubiquitination	LQVLPEIKHVERPAS HCCCCCCCCCCCCCC	39.68	29967540
448	Ubiquitination	PASDSWQKLEKSREY CCCHHHHHHHHHHHC	52.97	29967540
455	Phosphorylation	KLEKSREYKNSNQLR HHHHHHHCCCHHHHH	17.85	29978859
458	Phosphorylation	KSREYKNSNQLREYQ HHHHCCCHHHHHHHH	23.08	29978859
493	Phosphorylation	DEMGLGKTIQSITFL CCCCCCHHHHHHHHH	23.58	24275569
565	Phosphorylation	DAQGNPLSGVFKFHV CCCCCCCCCCEEEEE	33.88	21406692
609	Ubiquitination	RLKNRNCKLLEGLKL HHCCCCCCHHHHHHH	60.71	-
615	Ubiquitination	CKLLEGLKLMALEHK CCHHHHHHHHHHCCC	47.26	29967540
670	Ubiquitination	KTEEQVKKLQSILKP CCHHHHHHHHHHHHH	53.56	29967540
673	Phosphorylation	EQVKKLQSILKPMML HHHHHHHHHHHHHHH	40.08	24719451
710	Phosphorylation	LTNIQKKYYRAILEK CHHHHHHHHHHHHHH	12.76	-
711	Phosphorylation	TNIQKKYYRAILEKN HHHHHHHHHHHHHHC	11.49	-
717	Ubiquitination	YYRAILEKNFSFLTK HHHHHHHHCCCHHHC	60.90	-
737	Phosphorylation	NMPNLINTMMELRKC CCCHHHHHHHHHHHH	15.76	26425664
743	Ubiquitination	NTMMELRKCCNHPYL HHHHHHHHHCCCCCH	56.62	-
749	Phosphorylation	RKCCNHPYLINGAEE HHHCCCCCHHCCHHH	16.80	20860994
790	Ubiquitination	GKLVLIDKLLPKLIA CHHHHHHHHHHHHHC	44.95	-
808	Sulfoxidation	KVLIFSQMVRCLDIL EEEEEHHHHHHHHHH	1.67	31801345
900	Acetylation	CHRIGQSKAVKVYRL HHHHCCCHHHHHEEE	49.68	23749302
920	Ubiquitination	YEREMFDKASLKLGL HHHHCCCHHHHHHCC	28.72	-
924	Ubiquitination	MFDKASLKLGLDKAV CCCHHHHHHCCCHHH	37.70	33845483
929	Ubiquitination	SLKLGLDKAVLQDIN HHHHCCCHHHHHHHH	45.50	29967540
941	Phosphorylation	DINRKGGTNGVQQLS HHHHCCCCCHHHHHH	37.15	-
958	Ubiquitination	EVEDLLRKGAYGALM CHHHHHHCCCCCCCC	48.11	-
1003	Acetylation	GKGSTFAKASFVASG CCCCCEEEEEEEEEC	40.13	26051181
1003	Ubiquitination	GKGSTFAKASFVASG CCCCCEEEEEEEEEC	40.13	32142685
1005	Phosphorylation	GSTFAKASFVASGNR CCCEEEEEEEEECCC	21.39	-
1025	Ubiquitination	DDPNFWQKWAKIAEL CCCCHHHHHHHHHHC	39.45	-
1028	Ubiquitination	NFWQKWAKIAELDTE CHHHHHHHHHHCCHH	41.14	29967540
1040	Ubiquitination	DTEAKNEKESLVIDR CHHHCCCHHCCCCCC	63.09	29967540
1042	Phosphorylation	EAKNEKESLVIDRPR HHCCCHHCCCCCCHH	38.72	20873877
1059	Phosphorylation	KQTKHYNSFEEDELM HHCCCCCCCCHHHHH	27.20	30624053
1069	Phosphorylation	EDELMEFSELDSDSD HHHHHHHHHCCCCCC	24.76	30624053
1073	Phosphorylation	MEFSELDSDSDERPT HHHHHCCCCCCCCCC	52.19	33259812
1075	Phosphorylation	FSELDSDSDERPTRS HHHCCCCCCCCCCHH	45.37	24719451
1145	Phosphorylation	LVYCVKHYKGDEKIK HHHHHHHCCCCHHHH	15.79	20049867
1169	Phosphorylation	TKDGQAQTLQNHSGL CCCCCCCCHHHCCCC	33.07	22199227
1174	Phosphorylation	AQTLQNHSGLSAPVP CCCHHHCCCCCCCCC	49.32	22199227
1177	Phosphorylation	LQNHSGLSAPVPRGR HHHCCCCCCCCCCCC	33.77	22199227
1199	Ubiquitination	QLLIPELKDADWLAT CCCCCCCCCCCHHHH	49.56	29967540
1237	Phosphorylation	LLRVRMLYYLKAEIL HHHHHHHHHHHHHHH	9.45	21406692
1238	Phosphorylation	LRVRMLYYLKAEILG HHHHHHHHHHHHHHH	9.58	21406692
1250	Ubiquitination	ILGEAAEKAFEGSPA HHHHHHHHHHCCCCC	54.36	29967540
1255	Phosphorylation	AEKAFEGSPARELDV HHHHHCCCCCCCCCC	14.27	26699800
1284	Phosphorylation	WDAEADKSLLIGVFK CCHHCCHHHEEEHHH	29.02	20068231
1311	Ubiquitination	PALCFLEKVGMPDEK HHHHHHHHCCCCCHH	46.35	-
1327	Phosphorylation	LSAEQGVTDGTSDIP CCHHHCCCCCCCCCC	35.22	-
1339	Phosphorylation	DIPERGNTDKEDNAE CCCCCCCCCCCCCHH	51.80	25849741
1356	Phosphorylation	VDGLQKQTESSSDGG CCCHHHHHCCCCCCC	44.89	28111955
1358	Phosphorylation	GLQKQTESSSDGGDG CHHHHHCCCCCCCCC	38.23	28111955
1359	Phosphorylation	LQKQTESSSDGGDGV HHHHHCCCCCCCCCC	26.64	25849741
1360	Phosphorylation	QKQTESSSDGGDGVF HHHHCCCCCCCCCCC	49.94	25849741
1381	Phosphorylation	SRAAQDGSDPDKSPW CCCCCCCCCCCCCCC	55.02	22985185
1436	Phosphorylation	QEEMFRRTSEMDLIN HHHHHHHCCHHHHCC	25.45	28348404
1437	Phosphorylation	EEMFRRTSEMDLINK HHHHHHCCHHHHCCH	29.16	28857561
1444	Ubiquitination	SEMDLINKEAQKRWT CHHHHCCHHHHHHHH	47.64	29967540
1459	Phosphorylation	RREQADFYRTVSSFG HHHHHHHHHHHHHCC	13.11	-
1469	Phosphorylation	VSSFGVVYDQEKKTF HHHCCCEEECCCCEE	14.98	-
1491	Phosphorylation	ISRLDKKSDESLEQY HHCCCCCCCHHHHHH	52.96	27259358
1494	Phosphorylation	LDKKSDESLEQYFYS CCCCCCHHHHHHHHH	42.04	27259358
1500	Phosphorylation	ESLEQYFYSFVAMCR HHHHHHHHHHHHHHH	9.03	-
1540	Phosphorylation	ERAARTLYRIELLRK HHHHHHHHHHHHHHH	14.66	-
1590	Ubiquitination	DLLIGTAKHGLNRTD CCHHHHHCCCCCCCC	37.73	29967540
1599	Phosphorylation	GLNRTDCYIMNDPQL CCCCCCEEEECCCCH	13.15	30242111
1607	Phosphorylation	IMNDPQLSFLDAYRN EECCCCHHHHHHHHH	20.65	30242111
1612	Phosphorylation	QLSFLDAYRNYAQHK CHHHHHHHHHHHHHH	10.08	30242111
1640	Phosphorylation	YQTNSKLYESLTYSQ EECCCHHHHHCCHHH	13.75	27732954
1642	Phosphorylation	TNSKLYESLTYSQMS CCCHHHHHCCHHHHC	16.68	25072903
1644	Phosphorylation	SKLYESLTYSQMSRT CHHHHHCCHHHHCCC	30.33	25072903
1645	Phosphorylation	KLYESLTYSQMSRTS HHHHHCCHHHHCCCC	11.38	27732954
1646	Phosphorylation	LYESLTYSQMSRTSE HHHHCCHHHHCCCCH	17.74	25072903
1649	Phosphorylation	SLTYSQMSRTSESLE HCCHHHHCCCCHHHC	25.44	27732954
1651	Phosphorylation	TYSQMSRTSESLENE CHHHHCCCCHHHCCC	29.55	27732954
1652	Phosphorylation	YSQMSRTSESLENEP HHHHCCCCHHHCCCC	24.87	27732954
1654	Phosphorylation	QMSRTSESLENEPEN HHCCCCHHHCCCCCC	40.53	24719451
1667	Phosphorylation	ENLVRVESRDDHLSL CCCEEEEECCCCCCC	37.85	21712546
1673	Phosphorylation	ESRDDHLSLPDVTCE EECCCCCCCCCCCHH	34.14	23663014
1678	Phosphorylation	HLSLPDVTCENFISK CCCCCCCCHHHHHHH	22.83	30266825
1684	Phosphorylation	VTCENFISKVQDVIS CCHHHHHHHHHHHHH	23.72	21712546
1691	Phosphorylation	SKVQDVISINHDESL HHHHHHHHCCCCCCC	19.72	25849741
1710	Ubiquitination	LESMMYGKKVLSQEP HHHHHHCCCCCCCCC	23.40	29967540
1711	Ubiquitination	ESMMYGKKVLSQEPS HHHHHCCCCCCCCCC	44.01	29967540
1714	Phosphorylation	MYGKKVLSQEPSSFQ HHCCCCCCCCCCCCC	35.17	27732954
1718	Phosphorylation	KVLSQEPSSFQESPS CCCCCCCCCCCCCCC	42.93	27732954
1719	Phosphorylation	VLSQEPSSFQESPST CCCCCCCCCCCCCCC	41.48	27732954
1723	Phosphorylation	EPSSFQESPSTNTES CCCCCCCCCCCCCCC	17.23	25159151
1725	Phosphorylation	SSFQESPSTNTESRK CCCCCCCCCCCCCCC	43.50	27732954
1726	Phosphorylation	SFQESPSTNTESRKD CCCCCCCCCCCCCCE	49.93	27732954
1728	Phosphorylation	QESPSTNTESRKDVI CCCCCCCCCCCCEEE	35.11	27732954
1730	Phosphorylation	SPSTNTESRKDVITI CCCCCCCCCCEEEEE	42.46	27732954
1736	Phosphorylation	ESRKDVITISISKDG CCCCEEEEEEEECCC	14.44	23663014
1738	Phosphorylation	RKDVITISISKDGNC CCEEEEEEEECCCCC	16.50	23663014
1740	Phosphorylation	DVITISISKDGNCQS EEEEEEEECCCCCCC	20.22	23663014
1783	Phosphorylation	NGKHLLMSISKEGEL CCCEEEEEEECCCCE	24.55	29523821
1785	Phosphorylation	KHLLMSISKEGELCC CEEEEEEECCCCEEC	19.83	28450419
1793	Phosphorylation	KEGELCCSEAGQRPE CCCCEECCCCCCCCC	29.50	28555341
1812	Phosphorylation	LEAKCLASPSLNPGN HHHHHHCCCCCCCCC	11.32	24719451
1814	Phosphorylation	AKCLASPSLNPGNES HHHHCCCCCCCCCCC	37.98	26074081
1839	Phosphorylation	CDSKRNLSSDQQLID CCCCCCCCCHHHHHH	35.10	25159151
1840	Phosphorylation	DSKRNLSSDQQLIDL CCCCCCCCHHHHHHH	42.47	28450419
1851	Ubiquitination	LIDLLENKSLESKLI HHHHHHCCCHHHHHH	47.22	29967540
1852	Phosphorylation	IDLLENKSLESKLIL HHHHHCCCHHHHHHH	49.29	25849741
1855	Phosphorylation	LENKSLESKLILSQN HHCCCHHHHHHHHCC	37.75	21712546
1860	Phosphorylation	LESKLILSQNHSDEE HHHHHHHHCCCCHHH	23.18	22210691
1864	Phosphorylation	LILSQNHSDEEEEEE HHHHCCCCHHHHHHH	55.02	22210691
1897	Phosphorylation	VLHLTEPTTNISREK EEEECCCCCCCCHHH	26.66	-
1898	Phosphorylation	LHLTEPTTNISREKN EEECCCCCCCCHHHC	41.07	-
1916	Phosphorylation	QDETKKGSLEVANQT CCCHHCCCEEHHHCC	30.18	26425664
1923	Phosphorylation	SLEVANQTPGLQRAF CEEHHHCCCCHHHCC	21.09	26055452
1941	Acetylation	AACQCHCKHMERWMH HHHHHHHHHHHHHHC	23.48	25953088
1959	Ubiquitination	NDEFEIEKPKAYIPD CCCCEECCCHHHCCH	58.44	29967540
1972	Phosphorylation	PDLFKSKTNTIAMEG CHHHHCCCCEEEECC	44.69	-
1992	Sumoylation	PSQPFKVKHELLKEP CCCCCCCCHHHHHCC	31.77	-
1992	Sumoylation	PSQPFKVKHELLKEP CCCCCCCCHHHHHCC	31.77	-
1997	Ubiquitination	KVKHELLKEPWKESA CCCHHHHHCCCCCCC	74.49	29967540
2041	Phosphorylation	DRDGNCHSQDYPGKY CCCCCCCCCCCCCCC	27.26	17525332
2048	Phosphorylation	SQDYPGKYSEEESKS CCCCCCCCCHHHHCC	27.51	27732954
2049	Phosphorylation	QDYPGKYSEEESKSS CCCCCCCCHHHHCCC	41.85	27732954
2053	Phosphorylation	GKYSEEESKSSTSGI CCCCHHHHCCCCCCC	40.91	27732954
2055	Phosphorylation	YSEEESKSSTSGITG CCHHHHCCCCCCCCC	48.40	25159151
2056	Phosphorylation	SEEESKSSTSGITGD CHHHHCCCCCCCCCC	30.26	25159151
2057	Phosphorylation	EEESKSSTSGITGDI HHHHCCCCCCCCCCH	37.76	25159151
2058	Phosphorylation	EESKSSTSGITGDIG HHHCCCCCCCCCCHH	30.10	29507054
2061	Phosphorylation	KSSTSGITGDIGDEL CCCCCCCCCCHHHHH	32.12	27732954
2075	Phosphorylation	LQEARAPTIAQLLQE HHHCCCCHHHHHHHH	28.14	27050516
2083	Ubiquitination	IAQLLQEKTLYSFSE HHHHHHHHHCCCCCC	30.76	29967540
2084	Phosphorylation	AQLLQEKTLYSFSEW HHHHHHHHCCCCCCC	30.12	26270265
2086	Phosphorylation	LLQEKTLYSFSEWPK HHHHHHCCCCCCCCC	16.95	26270265
2087	Phosphorylation	LQEKTLYSFSEWPKD HHHHHCCCCCCCCCC	25.96	26270265
2089	Phosphorylation	EKTLYSFSEWPKDRV HHHCCCCCCCCCCCE	32.58	26270265
2138	Phosphorylation	TSSAGSRTSLSEPEA CCCCCCCCCCCCHHH	35.40	28348404
2139	Phosphorylation	SSAGSRTSLSEPEAA CCCCCCCCCCCHHHH	28.87	28348404
2141	Phosphorylation	AGSRTSLSEPEAAEH CCCCCCCCCHHHHHH	51.37	28348404
2149	Phosphorylation	EPEAAEHSFSNGAAL CHHHHHHCCCCHHHH	23.13	28348404
2151	Phosphorylation	EAAEHSFSNGAALAA HHHHHCCCCHHHHHH	37.05	28348404
2164	Phosphorylation	AAQIHKESFLAPVFT HHHHHHHHCCCEECC	30.29	28674419
2172	Ubiquitination	FLAPVFTKDEQKHRR CCCEECCCCHHCCCC	48.04	29967540
2181	Phosphorylation	EQKHRRPYEFEVERD HHCCCCCCCEEECHH	31.29	-
2284	Phosphorylation	LRRDDAATRRRRGRR CCCCCHHHHHHHCCH	26.82	22798277
2355	Phosphorylation	QAEKSIPSKSLLDWL HHHHHCCCHHHHHHH	32.95	24719451
2356	Ubiquitination	AEKSIPSKSLLDWLR HHHHCCCHHHHHHHH	39.51	-
2357	Phosphorylation	EKSIPSKSLLDWLRQ HHHCCCHHHHHHHHH	38.20	22199227
2384	Ubiquitination	ANFSDKPKQRRPRCK CCCCCCCCCCCCCCC	63.28	-
2399	Phosphorylation	EPGKLDVSSLSGEER CCCCCCHHHCCCCCC	25.81	21815630
2400	Phosphorylation	PGKLDVSSLSGEERV CCCCCHHHCCCCCCC	26.80	21815630
2402	Phosphorylation	KLDVSSLSGEERVPA CCCHHHCCCCCCCCC	46.21	25159151
2412	Ubiquitination	ERVPAIPKEPGLRGF CCCCCCCCCCCCCCC	71.12	29967540
2417	Methylation	IPKEPGLRGFLPENK CCCCCCCCCCCCCCC	39.47	-
2424	Ubiquitination	RGFLPENKFNHTLAE CCCCCCCCCCCCCCC	45.97	-
2428	Phosphorylation	PENKFNHTLAEPILR CCCCCCCCCCCHHHH	28.86	28555341
2437	Phosphorylation	AEPILRDTGPRRRGR CCHHHHCCCCCCCCC	42.52	28555341
2652	Phosphorylation	SEIVGLESQKRKKKK HHHCCCHHHHCCCCC	46.15	25159151
2654	Ubiquitination	IVGLESQKRKKKKTK HCCCHHHHCCCCCCC	75.39	29967540
2667	Phosphorylation	TKGDNPNSHPEPAPS CCCCCCCCCCCCCCC	41.50	29978859
2674	Phosphorylation	SHPEPAPSCEREPSG CCCCCCCCCCCCCCC	30.62	26657352
2680	Phosphorylation	PSCEREPSGDENCAE CCCCCCCCCCCCCCC	54.87	25849741
2689	Phosphorylation	DENCAEPSAPLPAER CCCCCCCCCCCCCCH	33.74	29978859
2710	Phosphorylation	GEGALKDSNNDTN-- CCCCCCCCCCCCC--	35.63	21712546
2714	Phosphorylation	LKDSNNDTN------ CCCCCCCCC------	44.97	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CHD6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHD6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CHD3_HUMAN	CHD3	physical	17027977

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CHD6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1069 AND SER-1073, ANDMASS SPECTROMETRY.	17081983 [Abstract]