VANG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VANG2_HUMAN
• UniProt AC: Q9ULK5
• Protein Name: Vang-like protein 2
• Gene Name: VANGL2
• Organism: Homo sapiens (Human).
• Sequence Length: 521
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity)..
• Protein Sequence: MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGGRGDKSVTIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLDCSRHLGVAAGATLALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVVSYWLFYGVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKFVMRLQSETSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTESQYSGY -----CCCCCHHCCC	35.92	27732954
5	Phosphorylation	---MDTESQYSGYSY ---CCCCCHHCCCCC	36.19	27732954
7	Phosphorylation	-MDTESQYSGYSYKS -CCCCCHHCCCCCCC	17.22	27732954
8	Phosphorylation	MDTESQYSGYSYKSG CCCCCHHCCCCCCCC	24.50	27732954
10	Phosphorylation	TESQYSGYSYKSGHS CCCHHCCCCCCCCCC	11.68	27732954
11	Phosphorylation	ESQYSGYSYKSGHSR CCHHCCCCCCCCCCC	29.61	27732954
12	Phosphorylation	SQYSGYSYKSGHSRS CHHCCCCCCCCCCCC	10.73	27732954
42	Ubiquitination	RDGGRGDKSVTIQAP CCCCCCCCCEEEECC	50.04	-
43	Phosphorylation	DGGRGDKSVTIQAPG CCCCCCCCEEEECCC	29.27	25002506
45	Phosphorylation	GRGDKSVTIQAPGEP CCCCCCEEEECCCCC	17.92	25002506
58	Phosphorylation	EPLLDNESTRGDERD CCCCCCCCCCCCCCC	29.65	30266825
59	Phosphorylation	PLLDNESTRGDERDD CCCCCCCCCCCCCCC	32.28	30266825
71	Phosphorylation	RDDNWGETTTVVTGT CCCCCCCCEEEEEEC	24.67	27732954
72	Phosphorylation	DDNWGETTTVVTGTS CCCCCCCEEEEEECC	17.19	30266825
73	Phosphorylation	DNWGETTTVVTGTSE CCCCCCEEEEEECCC	22.02	30266825
76	Phosphorylation	GETTTVVTGTSEHSI CCCEEEEEECCCCCC	30.33	30266825
78	Phosphorylation	TTTVVTGTSEHSISH CEEEEEECCCCCCCH	22.90	30266825
79	Phosphorylation	TTVVTGTSEHSISHD EEEEEECCCCCCCHH	34.36	30266825
82	Phosphorylation	VTGTSEHSISHDDLT EEECCCCCCCHHHHH	23.02	30266825
84	Phosphorylation	GTSEHSISHDDLTRI ECCCCCCCHHHHHHH	24.71	30266825
89	Phosphorylation	SISHDDLTRIAKDME CCCHHHHHHHHHHCC	27.33	30266825
174	Phosphorylation	FFRRPKASLPRVFVL HHCCCCCCCCHHHHH	45.06	24719451
195	Phosphorylation	LVFLLVVSYWLFYGV HHHHHHHHHHHHHHH	11.78	-
196	Phosphorylation	VFLLVVSYWLFYGVR HHHHHHHHHHHHHHH	8.43	-
200	Phosphorylation	VVSYWLFYGVRILDA HHHHHHHHHHHHHCH	16.73	-
258	Phosphorylation	VRSTDGASRFYNVGH EECCCCCCCEEEECC	28.58	23532336
267	Phosphorylation	FYNVGHLSIQRVAVW EEEECCHHHHHHHHH	15.82	24719451
279	Phosphorylation	AVWILEKYYHDFPVY HHHHHHHHCCCCCCC	9.17	26657352
286	Phosphorylation	YYHDFPVYNPALLNL HCCCCCCCCHHHHCC	18.70	26657352
303	Phosphorylation	SVLAKKVSGFKVYSL HHHHHHCCCCEEEEC	47.60	24719451
306	Ubiquitination	AKKVSGFKVYSLGEE HHHCCCCEEEECCCC	43.73	-
308	Phosphorylation	KVSGFKVYSLGEENS HCCCCEEEECCCCCC	9.96	25884760
309	Phosphorylation	VSGFKVYSLGEENST CCCCEEEECCCCCCC	32.65	-
315	Phosphorylation	YSLGEENSTNNSTGQ EECCCCCCCCCCCHH	35.47	24719451
316	Phosphorylation	SLGEENSTNNSTGQS ECCCCCCCCCCCHHH	50.42	28348404
337	Phosphorylation	AARRRDNSHNEYYYE HHHHCCCCCCCCCCH	31.79	-
341	Phosphorylation	RDNSHNEYYYEEAEH CCCCCCCCCCHHHHH	19.37	25884760
342	Phosphorylation	DNSHNEYYYEEAEHE CCCCCCCCCHHHHHH	9.75	-
343	Phosphorylation	NSHNEYYYEEAEHER CCCCCCCCHHHHHHH	13.34	-
379	Ubiquitination	RLQEEEQKNPREVMD HHHHHHHHCHHHHCC	72.67	-
507	Ubiquitination	SEEFVDPKSHKFVMR CHHHCCCCCCCHHHH	61.81	-
517	Phosphorylation	KFVMRLQSETSV--- CHHHHHHHCCCC---	47.65	28176443
519	Phosphorylation	VMRLQSETSV----- HHHHHHCCCC-----	39.78	28176443
520	Phosphorylation	MRLQSETSV------ HHHHHCCCC------	23.06	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VANG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VANG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VANG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VANG1_HUMAN	VANGL1	physical	26754771
SQSTM_HUMAN	SQSTM1	physical	26754771
MK08_HUMAN	MAPK8	physical	26754771
HSP7C_HUMAN	HSPA8	physical	28514442
RNF41_HUMAN	RNF41	physical	28481871
DVL1_MOUSE	Dvl1	physical	28481871

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 182940: Neural tube defects (NTD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.