LS14B_HUMAN - dbPTM
LS14B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LS14B_HUMAN
UniProt AC Q9BX40
Protein Name Protein LSM14 homolog B
Gene Name LSM14B
Organism Homo sapiens (Human).
Sequence Length 385
Subcellular Localization
Protein Description May play a role in control of mRNA translation..
Protein Sequence MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAASSLLSQQYAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSGSSGTPY
------CCCCCCCCC		47.5919413330
2Phosphorylation------MSGSSGTPY
------CCCCCCCCC		47.5923663014
4Phosphorylation----MSGSSGTPYLG
----CCCCCCCCCCC		20.4923663014
5Phosphorylation---MSGSSGTPYLGS
---CCCCCCCCCCCC		50.6523663014
7Phosphorylation-MSGSSGTPYLGSKI
-CCCCCCCCCCCCHH		15.6523663014
9PhosphorylationSGSSGTPYLGSKISL
CCCCCCCCCCCHHEE		24.4323663014
12PhosphorylationSGTPYLGSKISLISK
CCCCCCCCHHEEEEE		24.9923663014
13UbiquitinationGTPYLGSKISLISKA
CCCCCCCHHEEEEEC		34.2222505724
15PhosphorylationPYLGSKISLISKAQI
CCCCCHHEEEEECEE		24.3224719451
17UbiquitinationLGSKISLISKAQIRY
CCCHHEEEEECEEEE		2.9522817900
18PhosphorylationGSKISLISKAQIRYE
CCHHEEEEECEEEEE		27.5123663014
18UbiquitinationGSKISLISKAQIRYE
CCHHEEEEECEEEEE		27.5122817900
19AcetylationSKISLISKAQIRYEG
CHHEEEEECEEEEEE		37.0025953088
19UbiquitinationSKISLISKAQIRYEG
CHHEEEEECEEEEEE		37.00-
28 (in isoform 3)Phosphorylation-4.5423927012
32 (in isoform 3)Phosphorylation-39.9629116813
36 (in isoform 3)Phosphorylation-27.3723927012
37 (in isoform 3)Phosphorylation-18.9525159151
39 (in isoform 3)Phosphorylation-11.2425159151
40 (in isoform 3)Phosphorylation-4.0525159151
41 (in isoform 3)Phosphorylation-9.8823927012
42UbiquitinationNSTVALAKVRSFGTE
CCEEEEEEEHHCCCC		38.7422053931
42 (in isoform 1)Ubiquitination-38.7422053931
43 (in isoform 3)Phosphorylation-5.2923927012
48 (in isoform 3)Phosphorylation-32.4729978859
53PhosphorylationFGTEDRPTDRPAPPR
CCCCCCCCCCCCCCH		45.60-
53 (in isoform 3)Phosphorylation-45.6022199227
54 (in isoform 3)Phosphorylation-58.1922199227
60 (in isoform 3)Phosphorylation-53.7922199227
64PhosphorylationAPPREEIYEYIIFRG
CCCHHHHHEEEEEEC		13.1325884760
66PhosphorylationPREEIYEYIIFRGSD
CHHHHHEEEEEECCC		5.15-
70 (in isoform 3)Phosphorylation-33.0422210691
77 (in isoform 3)Phosphorylation-2.3622210691
84UbiquitinationITVCEPPKAQHTLPQ
CEEECCCCCCCCCCC		71.9729967540
86 (in isoform 3)Phosphorylation-35.9022210691
88PhosphorylationEPPKAQHTLPQDPAI
CCCCCCCCCCCCCHH		28.2227251275
92UbiquitinationAQHTLPQDPAIVQSS
CCCCCCCCCHHHHCC		32.4322817900
93UbiquitinationQHTLPQDPAIVQSSL
CCCCCCCCHHHHCCC		20.7422817900
98PhosphorylationQDPAIVQSSLGSASA
CCCHHHHCCCCCCCC		19.3520873877
99PhosphorylationDPAIVQSSLGSASAS
CCHHHHCCCCCCCCC		21.4720873877
102PhosphorylationIVQSSLGSASASPFQ
HHHCCCCCCCCCCCC		25.0930576142
104PhosphorylationQSSLGSASASPFQPH
HCCCCCCCCCCCCCC		30.8625159151
104 (in isoform 3)Phosphorylation-30.8621712546
106PhosphorylationSLGSASASPFQPHVP
CCCCCCCCCCCCCCC		24.6125159151
110 (in isoform 3)Phosphorylation-30.7225159151
114PhosphorylationPFQPHVPYSPFRGMA
CCCCCCCCCCCCCCC		28.0821712546
115PhosphorylationFQPHVPYSPFRGMAP
CCCCCCCCCCCCCCC		16.1125159151
118MethylationHVPYSPFRGMAPYGP
CCCCCCCCCCCCCCH		37.0454557173
119 (in isoform 3)Phosphorylation-19.5821712546
121 (in isoform 3)Phosphorylation-9.2921712546
128UbiquitinationAPYGPLAASSLLSQQ
CCCCHHHHHHHHHHH		13.8222817900
128 (in isoform 3)Ubiquitination-13.8221906983
129UbiquitinationPYGPLAASSLLSQQY
CCCHHHHHHHHHHHH		18.8622817900
147 (in isoform 2)Phosphorylation-30.3623927012
148PhosphorylationGLGAGFPSIPVGKSP
CCCCCCCCCCCCCCH		36.9429523821
151 (in isoform 2)Phosphorylation-16.7629116813
154PhosphorylationPSIPVGKSPMVEQAV
CCCCCCCCHHHHHHH		16.5829255136
155 (in isoform 2)Phosphorylation-34.0323927012
156SulfoxidationIPVGKSPMVEQAVQT
CCCCCCHHHHHHHHH		7.1821406390
156 (in isoform 2)Phosphorylation-7.1825159151
158 (in isoform 2)Phosphorylation-26.9425159151
159UbiquitinationGKSPMVEQAVQTGSA
CCCHHHHHHHHHCCC		35.1123000965
159 (in isoform 2)Phosphorylation-35.1125159151
160 (in isoform 2)Phosphorylation-5.0623927012
161UbiquitinationSPMVEQAVQTGSADN
CHHHHHHHHHCCCCC		5.3823000965
162 (in isoform 2)Phosphorylation-43.0623927012
163PhosphorylationMVEQAVQTGSADNLN
HHHHHHHHCCCCCCC		26.8921712546
165PhosphorylationEQAVQTGSADNLNAK
HHHHHHCCCCCCCCC		35.5230278072
167 (in isoform 2)Phosphorylation-62.9429978859
172AcetylationSADNLNAKKLLPGKG
CCCCCCCCCCCCCCC		42.7725953088
172UbiquitinationSADNLNAKKLLPGKG
CCCCCCCCCCCCCCC		42.7723000965
172 (in isoform 1)Ubiquitination-42.7722053931
172 (in isoform 2)Phosphorylation-42.7722199227
173UbiquitinationADNLNAKKLLPGKGT
CCCCCCCCCCCCCCC		53.5022817900
173 (in isoform 2)Phosphorylation-53.5022199227
178UbiquitinationAKKLLPGKGTTGTQL
CCCCCCCCCCCCCCC		51.6629967540
179 (in isoform 2)Phosphorylation-34.1322199227
185UbiquitinationKGTTGTQLNGRQAQP
CCCCCCCCCCEECCC		8.0324816145
198PhosphorylationQPSSKTASDVVQPAA
CCCCCCHHHHHCHHH		35.8528555341
198UbiquitinationQPSSKTASDVVQPAA
CCCCCCHHHHHCHHH		35.8522817900
199UbiquitinationPSSKTASDVVQPAAV
CCCCCHHHHHCHHHH		41.9922817900
211UbiquitinationAAVQAQGQVNDENRR
HHHHHCCCCCCCCCC		20.8222817900
212UbiquitinationAVQAQGQVNDENRRP
HHHHCCCCCCCCCCC		14.4322817900
224PhosphorylationRRPQRRRSGNRRTRN
CCCCHHHHCCCCHHC		38.31-
229PhosphorylationRRSGNRRTRNRSRGQ
HHHCCCCHHCCCCCC		29.1123911959
233PhosphorylationNRRTRNRSRGQNRPT
CCCHHCCCCCCCCCC		44.2924275748
233 (in isoform 2)Phosphorylation-44.2927762562
234MethylationRRTRNRSRGQNRPTN
CCHHCCCCCCCCCCC		47.6954557161
234UbiquitinationRRTRNRSRGQNRPTN
CCHHCCCCCCCCCCC		47.6923000965
236UbiquitinationTRNRSRGQNRPTNVK
HHCCCCCCCCCCCCC		41.4723000965
237UbiquitinationRNRSRGQNRPTNVKE
HCCCCCCCCCCCCCC		55.5122817900
238UbiquitinationNRSRGQNRPTNVKEN
CCCCCCCCCCCCCCC		31.3722817900
240PhosphorylationSRGQNRPTNVKENTI
CCCCCCCCCCCCCEE		49.7823911959
247UbiquitinationTNVKENTIKFEGDFD
CCCCCCEEEEECCCC		7.8923000965
248SumoylationNVKENTIKFEGDFDF
CCCCCEEEEECCCCH		35.0128112733
248UbiquitinationNVKENTIKFEGDFDF
CCCCCEEEEECCCCH		35.0122817900
257PhosphorylationEGDFDFESANAQFNR
ECCCCHHHHHHHCCH		27.15-
258UbiquitinationGDFDFESANAQFNRE
CCCCHHHHHHHCCHH		14.2623000965
260UbiquitinationFDFESANAQFNREEL
CCHHHHHHHCCHHHH		18.3023000965
270UbiquitinationNREELDKEFKKKLNF
CHHHHHHHHHHHCCC		63.4723000965
271UbiquitinationREELDKEFKKKLNFK
HHHHHHHHHHHCCCC		20.2723000965
272UbiquitinationEELDKEFKKKLNFKD
HHHHHHHHHHCCCCC		50.5223000965
273UbiquitinationELDKEFKKKLNFKDD
HHHHHHHHHCCCCCC		68.7422817900
274UbiquitinationLDKEFKKKLNFKDDK
HHHHHHHHCCCCCCC		49.6122817900
283UbiquitinationNFKDDKAEKGEEKDL
CCCCCCHHHCCCCCE		68.3023000965
284UbiquitinationFKDDKAEKGEEKDLA
CCCCCHHHCCCCCEE		76.2023000965
286UbiquitinationDDKAEKGEEKDLAVV
CCCHHHCCCCCEEEE		73.3023000965
288UbiquitinationKAEKGEEKDLAVVTQ
CHHHCCCCCEEEEEE		54.4623000965
290UbiquitinationEKGEEKDLAVVTQSA
HHCCCCCEEEEEECC		6.0423000965
294PhosphorylationEKDLAVVTQSAEAPA
CCCEEEEEECCCCCC		15.3728796482
296PhosphorylationDLAVVTQSAEAPAEE
CEEEEEECCCCCCCC		20.7928796482
296UbiquitinationDLAVVTQSAEAPAEE
CEEEEEECCCCCCCC		20.7924816145
297UbiquitinationLAVVTQSAEAPAEED
EEEEEECCCCCCCCC		13.7323000965
301UbiquitinationTQSAEAPAEEDLLGP
EECCCCCCCCCCCCC		39.6023000965
310UbiquitinationEDLLGPNCYYDKSKS
CCCCCCCCCCCCCHH		3.6124816145
311PhosphorylationDLLGPNCYYDKSKSF
CCCCCCCCCCCCHHH		22.7228796482
312PhosphorylationLLGPNCYYDKSKSFF
CCCCCCCCCCCHHHH		21.0628796482
314UbiquitinationGPNCYYDKSKSFFDN
CCCCCCCCCHHHHHH		43.6023000965
315PhosphorylationPNCYYDKSKSFFDNI
CCCCCCCCHHHHHHH		30.5421712546
316UbiquitinationNCYYDKSKSFFDNIS
CCCCCCCHHHHHHHH		57.9623000965
317PhosphorylationCYYDKSKSFFDNISS
CCCCCCHHHHHHHHH		37.9328857561
323PhosphorylationKSFFDNISSELKTSS
HHHHHHHHHHHHHCC		24.8225159151
324PhosphorylationSFFDNISSELKTSSR
HHHHHHHHHHHHCCC		43.0525159151
327UbiquitinationDNISSELKTSSRRTT
HHHHHHHHHCCCCCC		42.1623000965
328PhosphorylationNISSELKTSSRRTTW
HHHHHHHHCCCCCCH		44.5523882029
329PhosphorylationISSELKTSSRRTTWA
HHHHHHHCCCCCCHH		21.9123917254
330PhosphorylationSSELKTSSRRTTWAE
HHHHHHCCCCCCHHH		30.8921712546
333PhosphorylationLKTSSRRTTWAEERK
HHHCCCCCCHHHHHC		26.1123882029
334PhosphorylationKTSSRRTTWAEERKL
HHCCCCCCHHHHHCC		22.3623882029
340UbiquitinationTTWAEERKLNTETFG
CCHHHHHCCCCCCCC		49.7423000965
342UbiquitinationWAEERKLNTETFGVS
HHHHHCCCCCCCCCC		38.6123000965
343PhosphorylationAEERKLNTETFGVSG
HHHHCCCCCCCCCCC		47.0028555341
345PhosphorylationERKLNTETFGVSGRF
HHCCCCCCCCCCCCC		24.5323186163
349PhosphorylationNTETFGVSGRFLRGR
CCCCCCCCCCCCCCC		25.3221712546
351MethylationETFGVSGRFLRGRSS
CCCCCCCCCCCCCCC		21.6618967049
353UbiquitinationFGVSGRFLRGRSSRG
CCCCCCCCCCCCCCC		5.6723000965
354MethylationGVSGRFLRGRSSRGG
CCCCCCCCCCCCCCC		35.4530760309
355UbiquitinationVSGRFLRGRSSRGGF
CCCCCCCCCCCCCCC		35.6523000965
356MethylationSGRFLRGRSSRGGFR
CCCCCCCCCCCCCCC		25.6530760315
363MethylationRSSRGGFRGGRGNGT
CCCCCCCCCCCCCCC		50.35-
366UbiquitinationRGGFRGGRGNGTTRR
CCCCCCCCCCCCCCC		37.9223000965
373MethylationRGNGTTRRNPTSHRA
CCCCCCCCCCCCCCC		51.9254557179
377PhosphorylationTTRRNPTSHRAGTGR
CCCCCCCCCCCCCCC		16.54-
379MethylationRRNPTSHRAGTGRV-
CCCCCCCCCCCCCC-		34.1854557167
379UbiquitinationRRNPTSHRAGTGRV-
CCCCCCCCCCCCCC-		34.1823000965
381UbiquitinationNPTSHRAGTGRV---
CCCCCCCCCCCC---		28.7623000965
389UbiquitinationTGRV-----------
CCCC-----------		23000965
391UbiquitinationRV-------------
CC-------------		23000965
392UbiquitinationV--------------
C--------------		23000965
402Ubiquitination------------------------
------------------------		23000965
405Ubiquitination---------------------------
---------------------------		24816145
415Ubiquitination-------------------------------------
-------------------------------------		23000965
417Ubiquitination---------------------------------------
---------------------------------------		23000965
428Ubiquitination--------------------------------------------------
--------------------------------------------------		23000965
441Ubiquitination---------------------------------------------------------------
---------------------------------------------------------------		24816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LS14B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LS14B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LS14B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEMG2_HUMANSEMG2physical
26186194
SEMG1_HUMANSEMG1physical
26186194
SIR3_HUMANSIRT3physical
26186194
ICK_HUMANICKphysical
26186194
SEMG2_HUMANSEMG2physical
28514442
SEMG1_HUMANSEMG1physical
28514442
SIR3_HUMANSIRT3physical
28514442
ICK_HUMANICKphysical
28514442
CASP3_HUMANCASP3physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LS14B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-115 ANDSER-154, AND MASS SPECTROMETRY.

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