dbPTM

NKTR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NKTR_HUMAN
UniProt AC	P30414
Protein Name	NK-tumor recognition protein {ECO:0000305\|PubMed:8421688}
Gene Name	NKTR {ECO:0000312\|HGNC:HGNC:7833}
Organism	Homo sapiens (Human).
Sequence Length	1462
Subcellular Localization	Cell membrane .
Protein Description	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. [PubMed: 20676357 Component of a putative tumor-recognition complex involved in the function of NK cells]
Protein Sequence	MGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSESSRYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Acetylation	DICPKTCKNFLCLCS CCCCHHCCCEEEEEC	56.84	26051181
47	Acetylation	LCLCSGEKGLGKTTG EEEECCCCCCCCCCC	64.06	25953088
60	Acetylation	TGKKLCYKGSTFHRV CCCCEECCCCHHHHH	45.44	30590759
95	Phosphorylation	SIYGGYFKDENFILK CEECCEECCCCEEEC	56.50	32645325
158	Phosphorylation	EQIENLKTDAASRPY HHHHCCCCCHHHCCC	33.75	28152594
162	Phosphorylation	NLKTDAASRPYADVR CCCCCHHHCCCCCEE	35.19	28152594
165	Phosphorylation	TDAASRPYADVRVID CCHHHCCCCCEEEEE	17.83	28152594
179	Sumoylation	DCGVLATKSIKDVFE ECCCEECHHHHHHHH	44.57	-
179	Acetylation	DCGVLATKSIKDVFE ECCCEECHHHHHHHH	44.57	25953088
179	Sumoylation	DCGVLATKSIKDVFE ECCCEECHHHHHHHH	44.57	-
182	Sumoylation	VLATKSIKDVFEKKR CEECHHHHHHHHHHC	55.73	-
182	Sumoylation	VLATKSIKDVFEKKR CEECHHHHHHHHHHC	55.73	-
202	Phosphorylation	SEGSDSSSNSSSSSE CCCCCCCCCCCCCCC	44.69	-
204	Phosphorylation	GSDSSSNSSSSSESS CCCCCCCCCCCCCCC	33.28	-
208	Phosphorylation	SSNSSSSSESSSESE CCCCCCCCCCCCHHH	43.37	-
210	Phosphorylation	NSSSSSESSSESELE CCCCCCCCCCHHHHH	40.90	32645325
225	Ubiquitination	HERSRRRKHKRRPKV HHHHHHHHHHCCHHH	52.22	-
227	Ubiquitination	RSRRRKHKRRPKVKR HHHHHHHHCCHHHHH	53.81	-
243	Phosphorylation	KKRRKEASSSEEPRN HHHHHHCCCCCCCCC	35.17	26055452
244	Phosphorylation	KRRKEASSSEEPRNK HHHHHCCCCCCCCCC	49.14	26055452
245	Phosphorylation	RRKEASSSEEPRNKH HHHHCCCCCCCCCCC	43.41	27794612
260	Phosphorylation	AMNPKGHSERSDTNE CCCCCCCCCCCCCCC	43.29	30576142
263	Phosphorylation	PKGHSERSDTNEKRS CCCCCCCCCCCCCCC	44.74	30576142
265	Phosphorylation	GHSERSDTNEKRSVD CCCCCCCCCCCCCCC	46.66	30576142
270	Phosphorylation	SDTNEKRSVDSSAKR CCCCCCCCCCCCCCC	41.15	28102081
273	Phosphorylation	NEKRSVDSSAKREKP CCCCCCCCCCCCCCC	30.00	28102081
274	O-linked_Glycosylation	EKRSVDSSAKREKPV CCCCCCCCCCCCCCC	33.09	30379171
274	Phosphorylation	EKRSVDSSAKREKPV CCCCCCCCCCCCCCC	33.09	28102081
279	Sumoylation	DSSAKREKPVVRPEE CCCCCCCCCCCCHHH	47.33	-
279	Acetylation	DSSAKREKPVVRPEE CCCCCCCCCCCCHHH	47.33	25953088
279	Sumoylation	DSSAKREKPVVRPEE CCCCCCCCCCCCHHH	47.33	-
305	Phosphorylation	RRDMPVVTAEPEPKI CCCCCEEECCCCCCC	26.07	28509920
311	Sumoylation	VTAEPEPKIPDVAPI EECCCCCCCCCCCCC	66.27	-
311	Sumoylation	VTAEPEPKIPDVAPI EECCCCCCCCCCCCC	66.27	-
320	Phosphorylation	PDVAPIVSDQKPSVS CCCCCCCCCCCCCCC	34.74	22199227
323	Sumoylation	APIVSDQKPSVSKSG CCCCCCCCCCCCCCC	44.22	-
323	Acetylation	APIVSDQKPSVSKSG CCCCCCCCCCCCCCC	44.22	25953088
323	Sumoylation	APIVSDQKPSVSKSG CCCCCCCCCCCCCCC	44.22	28112733
325	Phosphorylation	IVSDQKPSVSKSGRK CCCCCCCCCCCCCCE	46.16	22199227
327	Phosphorylation	SDQKPSVSKSGRKIK CCCCCCCCCCCCEEC	25.99	22199227
328	Acetylation	DQKPSVSKSGRKIKG CCCCCCCCCCCEECC	55.57	12439063
329	Phosphorylation	QKPSVSKSGRKIKGR CCCCCCCCCCEECCC	36.00	26055452
338	Phosphorylation	RKIKGRGTIRYHTPP CEECCCCEEEECCCC	10.83	20873877
341	Phosphorylation	KGRGTIRYHTPPRSR CCCCEEEECCCCCCC	13.24	20873877
343	Phosphorylation	RGTIRYHTPPRSRSC CCEEEECCCCCCCCC	26.50	28355574
347	Phosphorylation	RYHTPPRSRSCSESD EECCCCCCCCCCCCC	34.03	28355574
359	Phosphorylation	ESDDDDSSETPPHWK CCCCCCCCCCCCCHH	53.11	23927012
360	Phosphorylation	SDDDDSSETPPHWKE CCCCCCCCCCCCHHH	70.10	32142685
361	Phosphorylation	DDDDSSETPPHWKEE CCCCCCCCCCCHHHH	44.03	23927012
375	Phosphorylation	EMQRLRAYRPPSGEK HHHHHHHHCCCCCCC	19.74	23403867
379	Phosphorylation	LRAYRPPSGEKWSKG HHHHCCCCCCCCCCC	63.37	29255136
382	Sumoylation	YRPPSGEKWSKGDKL HCCCCCCCCCCCCCC	61.36	-
382	Sumoylation	YRPPSGEKWSKGDKL HCCCCCCCCCCCCCC	61.36	-
384	Phosphorylation	PPSGEKWSKGDKLSD CCCCCCCCCCCCCCC	37.52	25159151
388	Sumoylation	EKWSKGDKLSDPCSS CCCCCCCCCCCCCHH	59.57	-
388	Sumoylation	EKWSKGDKLSDPCSS CCCCCCCCCCCCCHH	59.57	-
390	Phosphorylation	WSKGDKLSDPCSSRW CCCCCCCCCCCHHCC	45.29	25262027
394	Phosphorylation	DKLSDPCSSRWDERS CCCCCCCHHCCCCCC	28.46	21815630
395	Phosphorylation	KLSDPCSSRWDERSL CCCCCCHHCCCCCCH	44.07	26552605
401	Phosphorylation	SSRWDERSLSQRSRS HHCCCCCCHHHHHCC	30.26	25159151
403	Phosphorylation	RWDERSLSQRSRSWS CCCCCCHHHHHCCCC	25.46	30108239
406	Phosphorylation	ERSLSQRSRSWSYNG CCCHHHHHCCCCCCC	24.03	28450419
408	Phosphorylation	SLSQRSRSWSYNGYY CHHHHHCCCCCCCCC	22.94	21712546
410	Phosphorylation	SQRSRSWSYNGYYSD HHHHCCCCCCCCCCC	15.23	17081983
411	Phosphorylation	QRSRSWSYNGYYSDL HHHCCCCCCCCCCCH	13.32	28450419
414	Phosphorylation	RSWSYNGYYSDLSTA CCCCCCCCCCCHHHH	8.99	28450419
415	Phosphorylation	SWSYNGYYSDLSTAR CCCCCCCCCCHHHHC	9.34	30108239
416	Phosphorylation	WSYNGYYSDLSTARH CCCCCCCCCHHHHCC	24.48	22617229
419	Phosphorylation	NGYYSDLSTARHSGH CCCCCCHHHHCCCCC	25.63	28450419
420	Phosphorylation	GYYSDLSTARHSGHH CCCCCHHHHCCCCCH	34.70	28450419
463	Phosphorylation	KRRILIPSDIESSKS CCEEECCCCHHCCHH	44.20	29255136
467	Phosphorylation	LIPSDIESSKSSTRR ECCCCHHCCHHHHHH	43.32	29255136
468	Phosphorylation	IPSDIESSKSSTRRM CCCCHHCCHHHHHHH	24.62	29255136
469	Sumoylation	PSDIESSKSSTRRMK CCCHHCCHHHHHHHH	58.67	-
469	Sumoylation	PSDIESSKSSTRRMK CCCHHCCHHHHHHHH	58.67	-
470	Phosphorylation	SDIESSKSSTRRMKS CCHHCCHHHHHHHHH	38.60	22167270
471	Phosphorylation	DIESSKSSTRRMKSS CHHCCHHHHHHHHHH	29.66	22167270
472	Phosphorylation	IESSKSSTRRMKSSC HHCCHHHHHHHHHHH	29.41	22167270
478	Phosphorylation	STRRMKSSCDRERSS HHHHHHHHHHHHHHH	17.96	-
485	Phosphorylation	SCDRERSSRSSSLSS HHHHHHHHHCHHHHH	42.26	22817900
488	Phosphorylation	RERSSRSSSLSSHHS HHHHHHCHHHHHHCC	33.90	25849741
489	Phosphorylation	ERSSRSSSLSSHHSS HHHHHCHHHHHHCCC	33.25	25849741
491	Phosphorylation	SSRSSSLSSHHSSKR HHHCHHHHHHCCCCC	29.58	22817900
492	Phosphorylation	SRSSSLSSHHSSKRD HHCHHHHHHCCCCCC	30.43	22817900
495	Phosphorylation	SSLSSHHSSKRDWSK HHHHHHCCCCCCCCC	31.93	20363803
496	Phosphorylation	SLSSHHSSKRDWSKS HHHHHCCCCCCCCCC	27.61	20363803
509	Phosphorylation	KSDKDVQSSLTHSSR CCHHHHHHHHCCCCH	27.45	20068231
510	Phosphorylation	SDKDVQSSLTHSSRD CHHHHHHHHCCCCHH	21.87	25849741
512	Phosphorylation	KDVQSSLTHSSRDSY HHHHHHHCCCCHHHH	22.97	20873877
514	Phosphorylation	VQSSLTHSSRDSYRS HHHHHCCCCHHHHHC	23.10	20363803
515	Phosphorylation	QSSLTHSSRDSYRSK HHHHCCCCHHHHHCC	32.28	20363803
518	Phosphorylation	LTHSSRDSYRSKSHS HCCCCHHHHHCCCCC	22.72	25849741
519	Phosphorylation	THSSRDSYRSKSHSQ CCCCHHHHHCCCCCC	24.16	27251275
521	Phosphorylation	SSRDSYRSKSHSQSY CCHHHHHCCCCCCCC	30.22	25849741
523	Phosphorylation	RDSYRSKSHSQSYSR HHHHHCCCCCCCCCC	29.62	-
529	Phosphorylation	KSHSQSYSRGSSRSR CCCCCCCCCCCCCCC	35.10	-
570	Phosphorylation	ASKSPRKTASQLSEN HCCCCCHHHHHHHCC	32.59	30108239
572	Phosphorylation	KSPRKTASQLSENKP CCCCHHHHHHHCCCC	36.56	17525332
575	Phosphorylation	RKTASQLSENKPVKT CHHHHHHHCCCCCCC	31.33	25159151
578	Sumoylation	ASQLSENKPVKTEPL HHHHHCCCCCCCCCC	47.32	-
578	Sumoylation	ASQLSENKPVKTEPL HHHHHCCCCCCCCCC	47.32	28112733
581	Sumoylation	LSENKPVKTEPLRAT HHCCCCCCCCCCHHH	56.55	-
581	Sumoylation	LSENKPVKTEPLRAT HHCCCCCCCCCCHHH	56.55	28112733
582	Phosphorylation	SENKPVKTEPLRATM HCCCCCCCCCCHHHH	42.97	24719451
588	Phosphorylation	KTEPLRATMAQNENV CCCCCHHHHCCCCCE	13.45	20873877
611	Phosphorylation	NIPVIPLSDSPPPSR CCCEEECCCCCCCCC	30.59	30266825
613	Phosphorylation	PVIPLSDSPPPSRWK CEEECCCCCCCCCCC	35.61	30266825
617	Phosphorylation	LSDSPPPSRWKPGQK CCCCCCCCCCCCCCC	57.45	30266825
627	Sumoylation	KPGQKPWKPSYERIQ CCCCCCCCCCHHHHH	32.39	-
627	Sumoylation	KPGQKPWKPSYERIQ CCCCCCCCCCHHHHH	32.39	-
629	Phosphorylation	GQKPWKPSYERIQEM CCCCCCCCHHHHHHH	35.58	26074081
630	Phosphorylation	QKPWKPSYERIQEMK CCCCCCCHHHHHHHH	20.11	26074081
637	Sumoylation	YERIQEMKAKTTHLL HHHHHHHHHHCCEEE	46.08	-
637	Methylation	YERIQEMKAKTTHLL HHHHHHHHHHCCEEE	46.08	23644510
637	Sumoylation	YERIQEMKAKTTHLL HHHHHHHHHHCCEEE	46.08	-
639	Sumoylation	RIQEMKAKTTHLLPI HHHHHHHHCCEEECC	48.73	-
639	Methylation	RIQEMKAKTTHLLPI HHHHHHHHCCEEECC	48.73	23644510
639	Sumoylation	RIQEMKAKTTHLLPI HHHHHHHHCCEEECC	48.73	28112733
648	Phosphorylation	THLLPIQSTYSLANI CEEECCCCEEEECCC	29.99	28796482
649	Phosphorylation	HLLPIQSTYSLANIK EEECCCCEEEECCCH	10.76	28796482
650	Phosphorylation	LLPIQSTYSLANIKE EECCCCEEEECCCHH	13.61	28796482
651	Phosphorylation	LPIQSTYSLANIKET ECCCCEEEECCCHHC	22.54	28796482
656	Sumoylation	TYSLANIKETGSSSS EEEECCCHHCCCCCC	49.37	28112733
658	Phosphorylation	SLANIKETGSSSSYH EECCCHHCCCCCCCC	37.04	-
666	Sumoylation	GSSSSYHKREKNSES CCCCCCCCCCCCCCC	54.76	-
666	Sumoylation	GSSSSYHKREKNSES CCCCCCCCCCCCCCC	54.76	28112733
671	Phosphorylation	YHKREKNSESDQSTY CCCCCCCCCCCHHHH	49.93	28102081
673	Phosphorylation	KREKNSESDQSTYSK CCCCCCCCCHHHHHC	40.55	21815630
676	Phosphorylation	KNSESDQSTYSKYSD CCCCCCHHHHHCCCC	34.01	28102081
678	Phosphorylation	SESDQSTYSKYSDRS CCCCHHHHHCCCCCC	14.38	-
679	Phosphorylation	ESDQSTYSKYSDRSS CCCHHHHHCCCCCCC	25.80	-
685	O-linked_Glycosylation	YSKYSDRSSESSPRS HHCCCCCCCCCCCCC	43.37	30379171
688	Phosphorylation	YSDRSSESSPRSRSR CCCCCCCCCCCCCCC	47.81	30576142
689	Phosphorylation	SDRSSESSPRSRSRS CCCCCCCCCCCCCCH	21.93	28102081
692	Phosphorylation	SSESSPRSRSRSSRS CCCCCCCCCCCHHHC	37.68	28102081
697	Phosphorylation	PRSRSRSSRSRSYSR CCCCCCHHHCHHHCC	32.91	24144214
699	Phosphorylation	SRSRSSRSRSYSRSY CCCCHHHCHHHCCHH	27.76	20068231
701	Phosphorylation	SRSSRSRSYSRSYTR CCHHHCHHHCCHHHH	28.80	20068231
702	Phosphorylation	RSSRSRSYSRSYTRS CHHHCHHHCCHHHHH	13.64	20068231
703	Phosphorylation	SSRSRSYSRSYTRSR HHHCHHHCCHHHHHH	18.92	20068231
705	Phosphorylation	RSRSYSRSYTRSRSL HCHHHCCHHHHHHHH	25.56	20860994
706	Phosphorylation	SRSYSRSYTRSRSLA CHHHCCHHHHHHHHH	12.69	28102081
707	Phosphorylation	RSYSRSYTRSRSLAS HHHCCHHHHHHHHHH	24.34	28102081
714	Phosphorylation	TRSRSLASSHSRSRS HHHHHHHHHCCCCCC	33.60	28102081
715	Phosphorylation	RSRSLASSHSRSRSP HHHHHHHHCCCCCCC	21.63	28102081
717	Phosphorylation	RSLASSHSRSRSPSS HHHHHHCCCCCCCCC	33.62	30576142
719	Phosphorylation	LASSHSRSRSPSSRS HHHHCCCCCCCCCCC	39.87	24719451
721	Phosphorylation	SSHSRSRSPSSRSHS HHCCCCCCCCCCCCC	30.31	30576142
724	Phosphorylation	SRSRSPSSRSHSRNK CCCCCCCCCCCCCCC	40.98	17081983
739	Phosphorylation	YSDHSQCSRSSSYTS CCCCCCCCCCCCCCC	27.79	24275748
741	Phosphorylation	DHSQCSRSSSYTSIS CCCCCCCCCCCCCCC	13.82	28674419
746	Phosphorylation	SRSSSYTSISSDDGR CCCCCCCCCCCCCHH	16.55	28102081
748	Phosphorylation	SSSYTSISSDDGRRA CCCCCCCCCCCHHHH	27.73	27134283
749	Phosphorylation	SSYTSISSDDGRRAK CCCCCCCCCCHHHHH	37.74	28674419
767	Phosphorylation	RSSGKKNSVSHKKHS HHCCCCCCCCCCCCC	33.60	-
769	Phosphorylation	SGKKNSVSHKKHSSS CCCCCCCCCCCCCCC	29.43	28985074
774	Phosphorylation	SVSHKKHSSSSEKTL CCCCCCCCCCCCHHH	40.57	24719451
775	Phosphorylation	VSHKKHSSSSEKTLH CCCCCCCCCCCHHHH	37.29	26270265
776	Phosphorylation	SHKKHSSSSEKTLHS CCCCCCCCCCHHHHH	45.60	26270265
777	Phosphorylation	HKKHSSSSEKTLHSK CCCCCCCCCHHHHHH	45.09	26270265
780	Phosphorylation	HSSSSEKTLHSKYVK CCCCCCHHHHHHHCC	26.17	26270265
783	Phosphorylation	SSEKTLHSKYVKGRD CCCHHHHHHHCCCCC	28.88	26270265
784	Acetylation	SEKTLHSKYVKGRDR CCHHHHHHHCCCCCH	43.23	25953088
787	Phosphorylation	TLHSKYVKGRDRSSC HHHHHHCCCCCHHHH	45.17	32142685
803	Phosphorylation	RKYSESRSSLDYSSD HHHHHCCCCCCCCCC	44.53	23312004
804	Phosphorylation	KYSESRSSLDYSSDS HHHHCCCCCCCCCCC	24.93	23312004
807	Phosphorylation	ESRSSLDYSSDSEQS HCCCCCCCCCCCHHH	18.50	23312004
808	Phosphorylation	SRSSLDYSSDSEQSS CCCCCCCCCCCHHHH	27.60	23312004
809	Phosphorylation	RSSLDYSSDSEQSSV CCCCCCCCCCHHHHH	38.64	23312004
811	Phosphorylation	SLDYSSDSEQSSVQA CCCCCCCCHHHHHHH	39.21	28102081
814	Phosphorylation	YSSDSEQSSVQATQS CCCCCHHHHHHHHHH	28.55	28102081
815	Phosphorylation	SSDSEQSSVQATQSA CCCCHHHHHHHHHHH	20.24	23312004
819	Phosphorylation	EQSSVQATQSAQEKE HHHHHHHHHHHHHHH	13.13	28102081
821	Phosphorylation	SSVQATQSAQEKEKQ HHHHHHHHHHHHHHH	27.80	28102081
847	Phosphorylation	KNRGEEKSKSERECP HCCCCCCCHHHHCCC	44.70	28985074
862	Sumoylation	HSKKRTLKENLSDHL HHHHHHHHHHHHHHH	43.90	-
862	Methylation	HSKKRTLKENLSDHL HHHHHHHHHHHHHHH	43.90	110869591
862	Sumoylation	HSKKRTLKENLSDHL HHHHHHHHHHHHHHH	43.90	-
866	Phosphorylation	RTLKENLSDHLRNGS HHHHHHHHHHHHCCC	34.27	30266825
880	Phosphorylation	SKPKRKNYAGSKWDS CCCCCCCCCCCCCCC	18.51	28450419
883	Phosphorylation	KRKNYAGSKWDSESN CCCCCCCCCCCCCCC	23.54	23090842
887	Phosphorylation	YAGSKWDSESNSERD CCCCCCCCCCCCCCC	41.64	25159151
889	Phosphorylation	GSKWDSESNSERDVT CCCCCCCCCCCCCCC	50.00	25159151
891	Phosphorylation	KWDSESNSERDVTKN CCCCCCCCCCCCCCC	43.20	25159151
896	Phosphorylation	SNSERDVTKNSKNDS CCCCCCCCCCCCCCC	28.88	30108239
902	Phosphorylation	VTKNSKNDSHPSSDK CCCCCCCCCCCCCCC	52.65	32142685
903	Phosphorylation	TKNSKNDSHPSSDKE CCCCCCCCCCCCCCC	46.84	20873877
906	Phosphorylation	SKNDSHPSSDKEEGE CCCCCCCCCCCCCCC	45.83	20873877
907	Phosphorylation	KNDSHPSSDKEEGEA CCCCCCCCCCCCCCC	58.09	20873877
915	Phosphorylation	DKEEGEATSDSESEV CCCCCCCCCCCCCCE	28.85	20873877
916	Phosphorylation	KEEGEATSDSESEVS CCCCCCCCCCCCCEE	46.30	20873877
918	Phosphorylation	EGEATSDSESEVSEI CCCCCCCCCCCEEEE	42.67	20873877
920	Phosphorylation	EATSDSESEVSEIHI CCCCCCCCCEEEEEE	47.45	20873877
923	Phosphorylation	SDSESEVSEIHIKVK CCCCCCEEEEEEEEE	27.12	21406692
940	Phosphorylation	TKSSTNTSLPDDNGA CCCCCCCCCCCCCCC	39.72	25627689
949	Sumoylation	PDDNGAWKSSKQRTS CCCCCCCCCCCCCCC	44.30	-
949	Acetylation	PDDNGAWKSSKQRTS CCCCCCCCCCCCCCC	44.30	26051181
949	Sumoylation	PDDNGAWKSSKQRTS CCCCCCCCCCCCCCC	44.30	-
963	Phosphorylation	STSDSEGSCSNSENN CCCCCCCCCCCCCCC	15.43	28102081
965	Phosphorylation	SDSEGSCSNSENNRG CCCCCCCCCCCCCCC	45.12	28102081
967	Phosphorylation	SEGSCSNSENNRGKP CCCCCCCCCCCCCCC	25.96	28102081
981	Phosphorylation	PQKHKHGSKENLKRE CCCCCCCCHHHHHHH	36.19	24719451
990	O-linked_Glycosylation	ENLKREHTKKVKEKL HHHHHHHHHHHHHHH	28.01	30379171
1040	Sumoylation	KQVTQESKEKKVSEN HHCCHHHHHHHCCCC	73.19	-
1040	Sumoylation	KQVTQESKEKKVSEN HHCCHHHHHHHCCCC	73.19	-
1043	Sumoylation	TQESKEKKVSENNET CHHHHHHHCCCCCHH	52.68	-
1043	Sumoylation	TQESKEKKVSENNET CHHHHHHHCCCCCHH	52.68	-
1045	Phosphorylation	ESKEKKVSENNETIK HHHHHHCCCCCHHHH	43.41	25849741
1057	Sumoylation	TIKDNILKTEKSSEE HHHHHHHHCCCCCHH	51.33	-
1057	Sumoylation	TIKDNILKTEKSSEE HHHHHHHHCCCCCHH	51.33	28112733
1058	Phosphorylation	IKDNILKTEKSSEED HHHHHHHCCCCCHHH	45.24	30177828
1061	Phosphorylation	NILKTEKSSEEDLSG HHHHCCCCCHHHHCC	36.43	25849741
1062	Phosphorylation	ILKTEKSSEEDLSGK HHHCCCCCHHHHCCC	56.95	25849741
1067	Phosphorylation	KSSEEDLSGKHDTVT CCCHHHHCCCCCEEE	59.11	23403867
1069	Acetylation	SEEDLSGKHDTVTVS CHHHHCCCCCEEEEE	34.63	26051181
1072	Phosphorylation	DLSGKHDTVTVSSDL HHCCCCCEEEEECCH	20.14	29255136
1074	Phosphorylation	SGKHDTVTVSSDLDQ CCCCCEEEEECCHHH	19.43	29255136
1076	Phosphorylation	KHDTVTVSSDLDQFT CCCEEEEECCHHHHC	14.58	23401153
1077	Phosphorylation	HDTVTVSSDLDQFTK CCEEEEECCHHHHCC	37.54	29255136
1083	Phosphorylation	SSDLDQFTKDDSKLS ECCHHHHCCCCCCCC	28.12	29255136
1090	Phosphorylation	TKDDSKLSISPTALN CCCCCCCCCCCCCCC	25.42	26074081
1092	Phosphorylation	DDSKLSISPTALNTE CCCCCCCCCCCCCHH	16.90	26074081
1094	Phosphorylation	SKLSISPTALNTEEN CCCCCCCCCCCHHHH	36.67	26074081
1098	Phosphorylation	ISPTALNTEENVACL CCCCCCCHHHHHHHH	45.59	26074081
1133	Phosphorylation	DDNMEICTPDRSSPA CCCCEECCCCCCCCC	33.61	26074081
1137	Phosphorylation	EICTPDRSSPAKVEE EECCCCCCCCCCCCC	48.32	25850435
1138	Phosphorylation	ICTPDRSSPAKVEET ECCCCCCCCCCCCCC	29.75	25850435
1145	Phosphorylation	SPAKVEETSPLGNAR CCCCCCCCCCCCCCC	23.34	30266825
1146	Phosphorylation	PAKVEETSPLGNARL CCCCCCCCCCCCCCC	22.77	19664994
1155	Phosphorylation	LGNARLDTPDINIVL CCCCCCCCCCCEEEE	27.70	19664994
1163	Sumoylation	PDINIVLKQDMATEH CCCEEEECCCCCCCC	33.10	28112733
1177	Sumoylation	HPQAEVVKQESSMSE CCCHHHHHCCCCCCH	54.23	-
1177	Sumoylation	HPQAEVVKQESSMSE CCCHHHHHCCCCCCH	54.23	25114211
1193	Sumoylation	KVLGEVGKQDSSSAS HHHHCCCCCCCCCHH	56.99	-
1193	Sumoylation	KVLGEVGKQDSSSAS HHHHCCCCCCCCCHH	56.99	-
1196	Phosphorylation	GEVGKQDSSSASLAS HCCCCCCCCCHHHHH	24.57	23186163
1197	Phosphorylation	EVGKQDSSSASLASA CCCCCCCCCHHHHHC	37.91	23186163
1203	Phosphorylation	SSSASLASAGESTGK CCCHHHHHCCCCCCC	41.94	28112733
1207	Phosphorylation	SLASAGESTGKKEVA HHHHCCCCCCCHHHH	41.35	23403867
1208	Phosphorylation	LASAGESTGKKEVAE HHHCCCCCCCHHHHH	49.03	23403867
1210	Sumoylation	SAGESTGKKEVAEKS HCCCCCCCHHHHHHH	45.94	-
1210	Acetylation	SAGESTGKKEVAEKS HCCCCCCCHHHHHHH	45.94	26051181
1210	Sumoylation	SAGESTGKKEVAEKS HCCCCCCCHHHHHHH	45.94	-
1216	Sumoylation	GKKEVAEKSQINLID CCHHHHHHHHHEECC	37.61	-
1216	Acetylation	GKKEVAEKSQINLID CCHHHHHHHHHEECC	37.61	25953088
1216	Sumoylation	GKKEVAEKSQINLID CCHHHHHHHHHEECC	37.61	28112733
1217	Phosphorylation	KKEVAEKSQINLIDK CHHHHHHHHHEECCC	28.00	-
1225	Sumoylation	QINLIDKKWKPLQGV HHEECCCCCCCCCCC	57.62	-
1225	Sumoylation	QINLIDKKWKPLQGV HHEECCCCCCCCCCC	57.62	28112733
1258	Sumoylation	LTTVPEMKPQGLRIE EEECCCCCCCCEEEE	32.31	-
1258	Sumoylation	LTTVPEMKPQGLRIE EEECCCCCCCCEEEE	32.31	28112733
1271	Sumoylation	IEIKSKNKVRPGSLF EEEEECCCCCCCCHH	43.27	-
1271	Sumoylation	IEIKSKNKVRPGSLF EEEEECCCCCCCCHH	43.27	-
1276	Phosphorylation	KNKVRPGSLFDEVRK CCCCCCCCHHHHHHH	28.66	20068231
1296	Phosphorylation	RRPRNQESSSDEQTP CCCCCCCCCCCCCCC	25.94	28102081
1297	Phosphorylation	RPRNQESSSDEQTPS CCCCCCCCCCCCCCC	40.84	21815630
1298	Phosphorylation	PRNQESSSDEQTPSR CCCCCCCCCCCCCCC	55.21	28102081
1302	Phosphorylation	ESSSDEQTPSRDDDS CCCCCCCCCCCCCCC	22.60	28290473
1304	Phosphorylation	SSDEQTPSRDDDSQS CCCCCCCCCCCCCCC	52.29	28102081
1309	Phosphorylation	TPSRDDDSQSRSPSR CCCCCCCCCCCCCCC	36.73	28102081
1311	Phosphorylation	SRDDDSQSRSPSRSR CCCCCCCCCCCCCCC	38.38	28102081
1313	Phosphorylation	DDDSQSRSPSRSRSK CCCCCCCCCCCCCCH	32.26	28102081
1315	Phosphorylation	DSQSRSPSRSRSKSE CCCCCCCCCCCCHHH	44.10	28102081
1333	Phosphorylation	RHRTRSVSYSHSRSR HHHHHCCCCCCCCCC	23.36	25599653
1335	Phosphorylation	RTRSVSYSHSRSRSR HHHCCCCCCCCCCCC	13.89	20363803
1337	Phosphorylation	RSVSYSHSRSRSRSS HCCCCCCCCCCCCCC	26.47	27794612
1339	Phosphorylation	VSYSHSRSRSRSSTS CCCCCCCCCCCCCCC	37.31	-
1341	Phosphorylation	YSHSRSRSRSSTSSY CCCCCCCCCCCCCCH	37.45	-
1343	Phosphorylation	HSRSRSRSSTSSYRS CCCCCCCCCCCCHHC	38.93	30576142
1346	Phosphorylation	SRSRSSTSSYRSRSY CCCCCCCCCHHCCCC	27.59	28102081
1347	Phosphorylation	RSRSSTSSYRSRSYS CCCCCCCCHHCCCCC	25.34	28102081
1348	Phosphorylation	SRSSTSSYRSRSYSR CCCCCCCHHCCCCCC	16.63	28102081
1350	Phosphorylation	SSTSSYRSRSYSRSR CCCCCHHCCCCCCHH	19.83	20068231
1352	Phosphorylation	TSSYRSRSYSRSRSR CCCHHCCCCCCHHCC	28.80	20068231
1353	Phosphorylation	SSYRSRSYSRSRSRG CCHHCCCCCCHHCCC	13.64	20068231
1354	Phosphorylation	SYRSRSYSRSRSRGW CHHCCCCCCHHCCCC	25.65	20068231
1356	Phosphorylation	RSRSYSRSRSRGWYS HCCCCCCHHCCCCCC	28.77	21406692
1358	Phosphorylation	RSYSRSRSRGWYSRG CCCCCHHCCCCCCCC	36.07	21406692
1363	Phosphorylation	SRSRGWYSRGRTRSR HHCCCCCCCCCCCCC	23.04	21406692
1373	Phosphorylation	RTRSRSSSYRSYKSH CCCCCCHHHHHHHCC	26.30	-
1377	Phosphorylation	RSSSYRSYKSHRTSS CCHHHHHHHCCCCCC	13.91	-
1390	O-linked_Glycosylation	SSRSRSRSSSYDPHS CCCCCCCCCCCCCCC	25.53	30379171
1390	Phosphorylation	SSRSRSRSSSYDPHS CCCCCCCCCCCCCCC	25.53	28102081
1391	Phosphorylation	SRSRSRSSSYDPHSR CCCCCCCCCCCCCCC	31.63	28102081
1392	Phosphorylation	RSRSRSSSYDPHSRS CCCCCCCCCCCCCCC	34.50	28102081
1393	Phosphorylation	SRSRSSSYDPHSRSR CCCCCCCCCCCCCCC	35.13	28102081
1397	Phosphorylation	SSSYDPHSRSRSYTY CCCCCCCCCCCCCCH	37.02	25849741
1401	Phosphorylation	DPHSRSRSYTYDSYY CCCCCCCCCCHHHCC	24.07	23663014
1402	Phosphorylation	PHSRSRSYTYDSYYS CCCCCCCCCHHHCCC	14.28	27732954
1403	Phosphorylation	HSRSRSYTYDSYYSR CCCCCCCCHHHCCCC	23.31	23663014
1404	Phosphorylation	SRSRSYTYDSYYSRS CCCCCCCHHHCCCCC	8.48	27732954
1406	Phosphorylation	SRSYTYDSYYSRSRS CCCCCHHHCCCCCCC	18.63	27732954
1407	Phosphorylation	RSYTYDSYYSRSRSR CCCCHHHCCCCCCCC	11.54	27732954
1408	Phosphorylation	SYTYDSYYSRSRSRS CCCHHHCCCCCCCCC	11.10	27732954
1409	Phosphorylation	YTYDSYYSRSRSRSR CCHHHCCCCCCCCCC	18.62	23663014
1411	Phosphorylation	YDSYYSRSRSRSRSQ HHHCCCCCCCCCCCC	28.77	25849741
1420	Phosphorylation	SRSRSQRSDSYHRGR CCCCCCCCCCCCCCC	24.22	24275748
1422	Phosphorylation	SRSQRSDSYHRGRSY CCCCCCCCCCCCCHH	24.88	24275748
1438	Phosphorylation	RRSRSCRSYGSDSES CCCCCCHHCCCCCCC	37.87	30576142
1441	Phosphorylation	RSCRSYGSDSESDRS CCCHHCCCCCCCCCC	29.72	28674419
1443	Phosphorylation	CRSYGSDSESDRSYS CHHCCCCCCCCCCCC	40.47	28787133
1445	Phosphorylation	SYGSDSESDRSYSHH HCCCCCCCCCCCCCC	42.13	30631047
1449	Phosphorylation	DSESDRSYSHHRSPS CCCCCCCCCCCCCCC	16.96	30576142
1450	Phosphorylation	SESDRSYSHHRSPSE CCCCCCCCCCCCCCC	17.67	30576142
1458	Phosphorylation	HHRSPSESSRYS--- CCCCCCCCCCCC---	25.18	25262027
1459	Phosphorylation	HRSPSESSRYS---- CCCCCCCCCCC----	31.05	25849741
1461	Phosphorylation	SPSESSRYS------ CCCCCCCCC------	22.23	25262027
1462	Phosphorylation	PSESSRYS------- CCCCCCCC-------	32.41	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NKTR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NKTR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NKTR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NKTR_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NKTR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-463; SER-887; SER-889AND SER-891, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-572, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-343; SER-347; SER-379;SER-406; SER-408 AND SER-410, AND MASS SPECTROMETRY.	17081983 [Abstract]