NEUA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUA_HUMAN
• UniProt AC: Q8NFW8
• Protein Name: N-acylneuraminate cytidylyltransferase
• Gene Name: CMAS
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Nucleus .
• Protein Description: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)..
• Protein Sequence: MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEHICLLMEKVNNSCQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSVEKGA -------CCCCCCCC	8.60	22814378
3	Phosphorylation	-----MDSVEKGAAT -----CCCCCCCCCC	30.77	28270605
6	Acetylation	--MDSVEKGAATSVS --CCCCCCCCCCCCC	52.25	25953088
6	Ubiquitination	--MDSVEKGAATSVS --CCCCCCCCCCCCC	52.25	24816145
10	Phosphorylation	SVEKGAATSVSNPRG CCCCCCCCCCCCCCC	29.18	23401153
11	Phosphorylation	VEKGAATSVSNPRGR CCCCCCCCCCCCCCC	20.87	28634120
13	Phosphorylation	KGAATSVSNPRGRPS CCCCCCCCCCCCCCC	40.67	23401153
16	Methylation	ATSVSNPRGRPSRGR CCCCCCCCCCCCCCC	58.99	-
18	Methylation	SVSNPRGRPSRGRPP CCCCCCCCCCCCCCC	27.57	-
21	Methylation	NPRGRPSRGRPPKLQ CCCCCCCCCCCCCCC	48.07	-
26	Acetylation	PSRGRPPKLQRNSRG CCCCCCCCCCCCCCC	60.99	25953088
37	Methylation	NSRGGQGRGVEKPPH CCCCCCCCCCCCCHH	37.79	-
41	Ubiquitination	GQGRGVEKPPHLAAL CCCCCCCCCHHHHHH	62.53	33845483
41	Acetylation	GQGRGVEKPPHLAAL CCCCCCCCCHHHHHH	62.53	25953088
52	Methylation	LAALILARGGSKGIP HHHHHHHCCCCCCCC	46.70	-
55	Phosphorylation	LILARGGSKGIPLKN HHHHCCCCCCCCCCC	30.45	24719451
56	Ubiquitination	ILARGGSKGIPLKNI HHHCCCCCCCCCCCC	65.22	27667366
61 (in isoform 1)	Ubiquitination	-	51.80	21890473
61 (in isoform 2)	Ubiquitination	-	51.80	21890473
61	Ubiquitination	GSKGIPLKNIKHLAG CCCCCCCCCCHHHHC	51.80	22817900
64	Ubiquitination	GIPLKNIKHLAGVPL CCCCCCCHHHHCCCH	41.79	22817900
64	Acetylation	GIPLKNIKHLAGVPL CCCCCCCHHHHCCCH	41.79	26051181
92	Phosphorylation	FQSVWVSTDHDEIEN CCEEEEECCHHHHHH	27.95	-
166	Phosphorylation	EMIREEGYDSVFSVV HHHHHCCCCHHHHHH	14.34	-
168	Phosphorylation	IREEGYDSVFSVVRR HHHCCCCHHHHHHHH	19.31	-
185	Ubiquitination	FRWSEIQKGVREVTE CCHHHHHHHHCCCCC	66.10	23000965
200	Acetylation	PLNLNPAKRPRRQDW CCCCCCCCCCCCCCC	65.28	25953088
200	Ubiquitination	PLNLNPAKRPRRQDW CCCCCCCCCCCCCCC	65.28	33845483
269	Acetylation	LRYGYFGKEKLKEIK HHHCCCCHHHHHHCE	41.60	26051181
292	Phosphorylation	CLTNGHIYVSGDQKE CCCCCEEEECCCCCE	5.27	-
312	Phosphorylation	VKDAIGISLLKKSGI HHHHHHHHHHHHCCC	23.57	24719451
331	Ubiquitination	ISERACSKQTLSSLK EEHHHCCCHHHHHCC	47.38	29967540
335	Phosphorylation	ACSKQTLSSLKLDCK HCCCHHHHHCCCCEE	36.69	26699800
336	Phosphorylation	CSKQTLSSLKLDCKM CCCHHHHHCCCCEEE	32.41	26699800
338	Acetylation	KQTLSSLKLDCKMEV CHHHHHCCCCEEEEE	44.20	25953088
342	Acetylation	SSLKLDCKMEVSVSD HHCCCCEEEEEEHHH	37.45	19810249
346	Phosphorylation	LDCKMEVSVSDKLAV CCEEEEEEHHHCHHH	11.55	21406692
348	Phosphorylation	CKMEVSVSDKLAVVD EEEEEEHHHCHHHHH	22.86	21406692
382	Ubiquitination	VSDEECLKRVGLSGA CCHHHHHHHHCCCCC	57.61	32015554
382	Acetylation	VSDEECLKRVGLSGA CCHHHHHHHHCCCCC	57.61	26051181
399	Ubiquitination	DACSTAQKAVGYICK CHHHHHHHHHHHHHC	42.44	32015554
399	Methylation	DACSTAQKAVGYICK CHHHHHHHHHHHHHC	42.44	23583077
406	Acetylation	KAVGYICKCNGGRGA HHHHHHHCCCCCCHH	22.60	26051181
427	Acetylation	HICLLMEKVNNSCQK HHHHHHHHHHHHHCC	35.98	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEUA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
DDB1_HUMAN	DDB1	physical	26344197
NAA15_HUMAN	NAA15	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.