EPHA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPHA5_HUMAN
• UniProt AC: P54756
• Protein Name: Ephrin type-A receptor 5
• Gene Name: EPHA5
• Organism: Homo sapiens (Human).
• Sequence Length: 1037
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite .
• Protein Description: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)..
• Protein Sequence: MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MRGSGPRGAGR ----CCCCCCCCCCC	52.43	-
66	Phosphorylation	NEVNLLDSRTVMGDL CCCCCCCCCCCCCCE	29.80	20068231
133	Phosphorylation	IFIELKFTLRDCNSL EEEEEEEEECCCCCC	21.21	24719451
197	Phosphorylation	DRVMKLNTEVRDVGP HHEEECCCEEEECCC	46.42	-
225	Phosphorylation	GACIALVSVRVYYKK HHHHHEEEEEHHHHC	12.69	24719451
264	N-linked_Glycosylation	EVSGSCVNHSVTDEP EEECCEECCCCCCCC	26.50	UniProtKB CARBOHYD
295	Phosphorylation	KCMCKAGYEEKNGTC HEEEECCCCCCCCEE	26.27	20068231
299	N-linked_Glycosylation	KAGYEEKNGTCQVCR ECCCCCCCCEEEECC	55.04	UniProtKB CARBOHYD
301	Phosphorylation	GYEEKNGTCQVCRPG CCCCCCCEEEECCCC	14.79	-
313	Phosphorylation	RPGFFKASPHIQSCG CCCCCCCCCCCCCCC	20.01	-
318	Phosphorylation	KASPHIQSCGKCPPH CCCCCCCCCCCCCCC	25.00	-
333	Phosphorylation	SYTHEEASTSCVCEK CCCCCCCCCCEEECH	24.92	22496350
351	Phosphorylation	RRESDPPTMACTRPP CCCCCCCCCCCCCCC	23.84	25332170
369	N-linked_Glycosylation	RNAISNVNETSVFLE CCCCCCCCCCEEEEE	51.59	UniProtKB CARBOHYD
387	Ubiquitination	PADTGGRKDVSYYIA CCCCCCCCCEEEEEE	66.80	-
423	N-linked_Glycosylation	PRQSGLKNTSVMMVD CCCCCCCCCEEEEEE	42.50	UniProtKB CARBOHYD
436	N-linked_Glycosylation	VDLLAHTNYTFEIEA EEECCCCCEEEEEEE	24.79	UniProtKB CARBOHYD
461	N-linked_Glycosylation	ARQYVSVNVTTNQAA CEEEEEEEEECCCCC	20.22	UniProtKB CARBOHYD
523	Phosphorylation	TIIKSKETTITAEGL EEEECCCEEEEECCC	27.51	30576142
524	Phosphorylation	IIKSKETTITAEGLK EEECCCEEEEECCCC	19.88	30576142
526	Phosphorylation	KSKETTITAEGLKPA ECCCEEEEECCCCCC	19.30	30576142
649	Phosphorylation	IKLPGVRTYIDPHTY CCCCCCEEEECCCCC	23.56	22322096
650	Phosphorylation	KLPGVRTYIDPHTYE CCCCCEEEECCCCCC	7.86	22322096
655	Phosphorylation	RTYIDPHTYEDPNQA EEEECCCCCCCHHHH	33.71	26356563
656	Phosphorylation	TYIDPHTYEDPNQAV EEECCCCCCCHHHHH	18.46	22322096
673	Phosphorylation	FAKEIEASCITIERV HHHHHHHHCEEEEEE	8.02	-
676	Phosphorylation	EIEASCITIERVIGA HHHHHCEEEEEEECC	22.55	-
699	Ubiquitination	GRLKLPGKRELPVAI CCCCCCCCCCCCEEE	40.54	-
708	Phosphorylation	ELPVAIKTLKVGYTE CCCEEEEEEECCCCH	26.21	22461510
710	Ubiquitination	PVAIKTLKVGYTEKQ CEEEEEEECCCCHHH	38.55	-
713	Phosphorylation	IKTLKVGYTEKQRRD EEEEECCCCHHHCCC	18.08	22461510
755	Phosphorylation	PVMIVTEYMENGSLD CEEEEEEEECCCCCC	10.60	18547520
790	Phosphorylation	GISAGMKYLSDMGYV HHHHHHHHHHHCCCC	11.53	22817900
796	Phosphorylation	KYLSDMGYVHRDLAA HHHHHCCCCCHHHHH	6.09	-
817	Phosphorylation	SNLVCKVSDFGLSRV CCEEEEECHHCCHHH	16.83	-
822	Phosphorylation	KVSDFGLSRVLEDDP EECHHCCHHHCCCCC	22.26	19369195
833	Phosphorylation	EDDPEAAYTTRGGKI CCCCCHHCCCCCCCC	18.72	27273156
834	Phosphorylation	DDPEAAYTTRGGKIP CCCCHHCCCCCCCCC	12.80	25159151
835	Phosphorylation	DPEAAYTTRGGKIPI CCCHHCCCCCCCCCC	18.03	25159151
856	Phosphorylation	AIAFRKFTSASDVWS HEECCCCCCHHHHHH	26.81	-
873	Phosphorylation	IVMWEVVSYGERPYW EEEEEEEECCCCCCE	32.37	-
879	Phosphorylation	VSYGERPYWEMTNQD EECCCCCCEECCCHH	21.88	29978859
883	Phosphorylation	ERPYWEMTNQDVIKA CCCCEECCCHHHHHH	20.43	29978859
953	Phosphorylation	VNASCRVSNLLAEHS HHHHHHHHHHHHHCC	11.47	20068231
960	Phosphorylation	SNLLAEHSPLGSGAY HHHHHHCCCCCCCCC	17.21	22199227
964	Phosphorylation	AEHSPLGSGAYRSVG HHCCCCCCCCCCHHH	28.12	20068231
967	Phosphorylation	SPLGSGAYRSVGEWL CCCCCCCCCHHHHHH	13.62	20068231
982	Phosphorylation	EAIKMGRYTEIFMEN HHHHCCCCEEEEEEC	11.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPHA5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPHA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPHA5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT3_HUMAN	STAT3	physical	15485908
DUS21_HUMAN	DUSP21	physical	28065597

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.