| UniProt ID | DUS21_HUMAN | |
|---|---|---|
| UniProt AC | Q9H596 | |
| Protein Name | Dual specificity protein phosphatase 21 | |
| Gene Name | DUSP21 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 190 | |
| Subcellular Localization |
Cytoplasm . Nucleus . Mitochondrion inner membrane Peripheral membrane protein Matrix side. |
|
| Protein Description | Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.. | |
| Protein Sequence | MTASASSFSSSQGVQQPSIYSFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKLFNNNTVRMINSPVGNIPDIYEKDLRMMISM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTASASSFS ------CCCCCCCCC | 29.35 | 24043423 | |
| 4 | Phosphorylation | ----MTASASSFSSS ----CCCCCCCCCCC | 21.37 | 24719451 | |
| 6 | Phosphorylation | --MTASASSFSSSQG --CCCCCCCCCCCCC | 29.44 | 24043423 | |
| 7 | Phosphorylation | -MTASASSFSSSQGV -CCCCCCCCCCCCCC | 28.94 | 24043423 | |
| 9 | Phosphorylation | TASASSFSSSQGVQQ CCCCCCCCCCCCCCC | 30.90 | 24043423 | |
| 10 | Phosphorylation | ASASSFSSSQGVQQP CCCCCCCCCCCCCCC | 25.35 | 24043423 | |
| 11 | Phosphorylation | SASSFSSSQGVQQPS CCCCCCCCCCCCCCC | 29.74 | 24043423 | |
| 18 | Phosphorylation | SQGVQQPSIYSFSQI CCCCCCCCEEEHHHH | 29.80 | 24043423 | |
| 20 | Phosphorylation | GVQQPSIYSFSQITR CCCCCCEEEHHHHHH | 14.17 | 24043423 | |
| 21 | Phosphorylation | VQQPSIYSFSQITRS CCCCCEEEHHHHHHH | 19.42 | 24043423 | |
| 23 | Phosphorylation | QPSIYSFSQITRSLF CCCEEEHHHHHHHHH | 18.09 | 24043423 | |
| 26 | Phosphorylation | IYSFSQITRSLFLSN EEEHHHHHHHHHHCC | 13.43 | 24719451 | |
| 28 | Phosphorylation | SFSQITRSLFLSNGV EHHHHHHHHHHCCCC | 18.15 | 23612710 | |
| 113 | Phosphorylation | CMAGVSRSASLCLAY HHHCCCHHHHHHHHH | 18.07 | - | |
| 115 | Phosphorylation | AGVSRSASLCLAYLM HCCCHHHHHHHHHHH | 22.36 | - | |
| 120 | Phosphorylation | SASLCLAYLMKYHSM HHHHHHHHHHHHHHC | 8.38 | - | |
| 134 | Phosphorylation | MSLLDAHTWTKSRRP CCCHHCCCCCCCCCC | 36.23 | 22210691 | |
| 171 | Phosphorylation | NTVRMINSPVGNIPD CEEEEECCCCCCCCH | 15.27 | 29083192 | |
| 180 | Phosphorylation | VGNIPDIYEKDLRMM CCCCCHHHHHHHHHH | 25.06 | 29083192 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DUS21_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DUS21_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DUS21_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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