QSPP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QSPP_HUMAN
• UniProt AC: Q5T6V5
• Protein Name: Queuosine salvage protein {ECO:0000303|PubMed:24911101}
• Gene Name: C9orf64
• Organism: Homo sapiens (Human).
• Sequence Length: 341
• Protein Description: Involved in salvaging queuosine..
• Protein Sequence: MDGLLNPRESSKFIAENSRDVFIDSGGVRRVAELLLAKAAGPELRVEGWKALHELNPRAADEAAVNWVFVTDTLNFSFWSEQDEHKCVVRYRGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDQVRNILRSDTDVSMPLVEERHRILNETGKILLEKFGGSFLNCVRESENSAQKLMHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEVEIRGCSLWCVELIRDCLLELIEQKGEKPNGEINSILLDYYLWDYAHDHREDMKGIPFHRIRCIYY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDGLLNPR -------CCCCCCHH		22814378
10	Phosphorylation	GLLNPRESSKFIAEN CCCCHHHHHCCHHHC		29978859
11	Phosphorylation	LLNPRESSKFIAENS CCCHHHHHCCHHHCC		29978859
12	Acetylation	LNPRESSKFIAENSR CCHHHHHCCHHHCCC		27452117
12	Ubiquitination	LNPRESSKFIAENSR CCHHHHHCCHHHCCC		-
18	Phosphorylation	SKFIAENSRDVFIDS HCCHHHCCCCEEECC		29978859
25	Phosphorylation	SRDVFIDSGGVRRVA CCCEEECCCHHHHHH		27251275
38	Ubiquitination	VAELLLAKAAGPELR HHHHHHHHHHCCCEE		-
45	Methylation	KAAGPELRVEGWKAL HHHCCCEEEHHHHHH		-
117	Phosphorylation	LDEGIPITSASYYAT HHCCCCCCCEEEEEE		20068231
118	Phosphorylation	DEGIPITSASYYATV HCCCCCCCEEEEEEE		20068231
120	Phosphorylation	GIPITSASYYATVTL CCCCCCEEEEEEEEH		20068231
121	Phosphorylation	IPITSASYYATVTLD CCCCCEEEEEEEEHH		20068231
122	Phosphorylation	PITSASYYATVTLDQ CCCCEEEEEEEEHHH		20068231
124	Phosphorylation	TSASYYATVTLDQVR CCEEEEEEEEHHHHH		20068231
126	Phosphorylation	ASYYATVTLDQVRNI EEEEEEEEHHHHHHH		20068231
136	Phosphorylation	QVRNILRSDTDVSMP HHHHHHHCCCCCCCH		18491316
138	Phosphorylation	RNILRSDTDVSMPLV HHHHHCCCCCCCHHH		18491316
157	Ubiquitination	RILNETGKILLEKFG HHHHHHCCHHHHHHC		-
162	Ubiquitination	TGKILLEKFGGSFLN HCCHHHHHHCCCHHH		-
201	Ubiquitination	DVTLFEGKRVSFYKR CCEEECCCEEEEHHE		-
253	Ubiquitination	LAHLGALKYSDDLLK HHHHCCCCCCHHHHH		-
260	Ubiquitination	KYSDDLLKKLLKGEM CCCHHHHHHHHCCCC		-
264	Ubiquitination	DLLKKLLKGEMLSYG HHHHHHHCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QSPP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QSPP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QSPP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NNRD_HUMAN	CARKD	physical	26344197
DPYD_HUMAN	DPYD	physical	26344197
ITPA_HUMAN	ITPA	physical	26344197
NEDD8_HUMAN	NEDD8	physical	26344197
NMRL1_HUMAN	NMRAL1	physical	26344197
KPYM_HUMAN	PKM	physical	26344197
NIF3L_HUMAN	NIF3L1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.