dbPTM

DUS28_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DUS28_HUMAN
UniProt AC	Q4G0W2
Protein Name	Dual specificity phosphatase 28
Gene Name	DUSP28
Organism	Homo sapiens (Human).
Sequence Length	176
Subcellular Localization
Protein Description	Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro). [PubMed: 24531476]
Protein Sequence	MGPAEAGRRGAASPVPPPLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQSCLQGEPPALGLGPEA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
13	Phosphorylation	AGRRGAASPVPPPLV CCCCCCCCCCCCCHH	26.37	19764811
114	S-palmitoylation	RSRSAAVCTAYLMRH CCHHHHHHHHHHHHH	1.22	29575903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DUS28_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DUS28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DUS28_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR3_HUMAN	UBR3	physical	27880917
DUS28_HUMAN	DUSP28	physical	27432908
QSPP_HUMAN	C9orf64	physical	27432908
PPIA_HUMAN	PPIA	physical	27432908
DHYS_HUMAN	DHPS	physical	27432908
IF4A2_HUMAN	EIF4A2	physical	27432908
DUS21_HUMAN	DUSP21	physical	27432908
RAD50_HUMAN	RAD50	physical	27432908
KAD6_HUMAN	AK6	physical	27432908
DYM_HUMAN	DYM	physical	27432908
MTCH1_HUMAN	MTCH1	physical	27432908
SPEE_HUMAN	SRM	physical	27432908
COPZ1_HUMAN	COPZ1	physical	27432908
DCTP1_HUMAN	DCTPP1	physical	27432908
DCTN2_HUMAN	DCTN2	physical	27432908
PPAC_HUMAN	ACP1	physical	27432908
ARF5_HUMAN	ARF5	physical	27432908
TAGL2_HUMAN	TAGLN2	physical	27432908
PRPS1_HUMAN	PRPS1	physical	27432908
CBX3_HUMAN	CBX3	physical	27432908
PFD2_HUMAN	PFDN2	physical	27432908
ICMT_HUMAN	ICMT	physical	27432908
PARK7_HUMAN	PARK7	physical	27432908
DCTN3_HUMAN	DCTN3	physical	27432908
CBWD1_HUMAN	CBWD1	physical	27432908
ECHD1_HUMAN	ECHDC1	physical	27432908

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DUS28_HUMAN

Related Literatures of Post-Translational Modification