| UniProt ID | ICMT_HUMAN | |
|---|---|---|
| UniProt AC | O60725 | |
| Protein Name | Protein-S-isoprenylcysteine O-methyltransferase | |
| Gene Name | ICMT | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 284 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.. | |
| Protein Sequence | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Phosphorylation | PGSEARLSLATFLLG CCCHHHHHHHHHHHH | 15.48 | - | |
| 278 | Ubiquitination | PTGLPFIKGVKVDL- CCCCCCCCCEECCC- | 59.01 | 21890473 | |
| 278 | Ubiquitination | PTGLPFIKGVKVDL- CCCCCCCCCEECCC- | 59.01 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ICMT_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ICMT_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ICMT_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RAC2_HUMAN | RAC2 | physical | 9614111 | |
| RHOA_HUMAN | RHOA | physical | 9614111 | |
| GRAN_HUMAN | GCA | physical | 28514442 | |
| PCCA_HUMAN | PCCA | physical | 28514442 | |
| STXB3_HUMAN | STXBP3 | physical | 28514442 | |
| OXSR1_HUMAN | OXSR1 | physical | 28514442 | |
| PPM1E_HUMAN | PPM1E | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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