CEGT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CEGT_HUMAN
• UniProt AC: Q16739
• Protein Name: Ceramide glucosyltransferase
• Gene Name: UGCG
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Golgi apparatus membrane; Multi-pass membrane protein.
• Protein Description: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase"..
• Protein Sequence: MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	LNKKATDKQPYSKLP HCCCCCCCCCCCCCC	49.14	21890473
49	Ubiquitination	TDKQPYSKLPGVSLL CCCCCCCCCCCCCCC	53.51	21890473
54	Phosphorylation	YSKLPGVSLLKPLKG CCCCCCCCCCCCCCC	33.62	24719451
57	Ubiquitination	LPGVSLLKPLKGVDP CCCCCCCCCCCCCCH	54.30	21890473
104	Ubiquitination	VCKKLLGKYPNVDAR HHHHHHCCCCCCCEE	58.46	21890473
117	Acetylation	ARLFIGGKKVGINPK EEEEECCEECCCCCC	38.79	-
117	2-Hydroxyisobutyrylation	ARLFIGGKKVGINPK EEEEECCEECCCCCC	38.79	-
124	Ubiquitination	KKVGINPKINNLMPG EECCCCCCCCCCCCC	54.28	21890473
162	Phosphorylation	TDMVNQMTEKVGLVH HHHHHHHHHHHCCCC	23.92	20886841
164	Ubiquitination	MVNQMTEKVGLVHGL HHHHHHHHHCCCCCC	32.22	-
209	Phosphorylation	VTGFKCVTGMSCLMR CCCCEECCCCHHHHC	36.32	-
374	Phosphorylation	ALWDPTISWRTGRYR HHCCCCCCCCCCCEE	17.00	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CEGT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CEGT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CEGT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RTN1_HUMAN	RTN1	physical	12873973
RTN3_HUMAN	RTN3	physical	12873973
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D05032: Miglustat (JAN/USAN/INN); Brazaves (TN); Zavesca (TN)
• D09893: Eliglustat (USAN/INN)
• D09894: Eliglustat tartrate (USAN)
• DrugBank
• DB00419: Miglustat