dbPTM

RTN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RTN1_HUMAN
UniProt AC	Q16799
Protein Name	Reticulon-1
Gene Name	RTN1
Organism	Homo sapiens (Human).
Sequence Length	776
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein.
Protein Description	May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells..
Protein Sequence	MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15 (in isoform 3)	Phosphorylation	-	21.86	-
34	Phosphorylation	EGENEAVTPKGATPA CCCCCCCCCCCCCCC	26.74	24719451
39	Phosphorylation	AVTPKGATPAPQAGE CCCCCCCCCCCCCCC	28.75	27486199
48	Phosphorylation	APQAGEPSPGLGARA CCCCCCCCCCCCHHH	27.57	30266825
60	Phosphorylation	ARAREAASREAGSGP HHHHHHHHHHCCCCC	37.39	23532336
65	Phosphorylation	AASREAGSGPARQSP HHHHHCCCCCCCCCC	48.96	23403867
71	Phosphorylation	GSGPARQSPVAMETA CCCCCCCCCCCCHHC	18.78	21082442
77	Phosphorylation	QSPVAMETASTGVAG CCCCCCHHCCCCCCC	16.90	28060719
79	Phosphorylation	PVAMETASTGVAGVS CCCCHHCCCCCCCHH	32.87	28060719
80	Phosphorylation	VAMETASTGVAGVSS CCCHHCCCCCCCHHH	32.96	28060719
86	Phosphorylation	STGVAGVSSAMDHTF CCCCCCHHHHCCCEE	16.09	28060719
87	Phosphorylation	TGVAGVSSAMDHTFS CCCCCHHHHCCCEEE	25.80	28060719
92	Phosphorylation	VSSAMDHTFSTTSKD HHHHCCCEEECCCCC	18.28	28060719
94	Phosphorylation	SAMDHTFSTTSKDGE HHCCCEEECCCCCCC	31.75	28060719
95	Phosphorylation	AMDHTFSTTSKDGEG HCCCEEECCCCCCCC	30.78	28060719
96	Phosphorylation	MDHTFSTTSKDGEGS CCCEEECCCCCCCCC	32.36	28060719
97	Phosphorylation	DHTFSTTSKDGEGSC CCEEECCCCCCCCCE	28.92	28060719
139	Phosphorylation	GHVTISESPEELGTP CEEEECCCHHHHCCC	30.71	24719451
145	Phosphorylation	ESPEELGTPGPSLPD CCHHHHCCCCCCCCC	37.38	24719451
163	Phosphorylation	IESRGLFSSDSGIEM CCCCCCCCCCCCCCC	37.97	27251275
164	Phosphorylation	ESRGLFSSDSGIEMT CCCCCCCCCCCCCCC	28.58	27251275
166	Phosphorylation	RGLFSSDSGIEMTPA CCCCCCCCCCCCCCC	43.55	26657352
196	Phosphorylation	MKAEAYKYIDITRPE HHHHHHHHCCCCCHH	7.37	27642862
200	O-linked_Glycosylation	AYKYIDITRPEEVKH HHHHCCCCCHHHHCC	36.10	28657654
278	Phosphorylation	QRRAPQITTPVKITL HHHCCCCCCCCEEEE	21.57	30266825
279	Phosphorylation	RRAPQITTPVKITLT HHCCCCCCCCEEEEE	27.93	30266825
284	Phosphorylation	ITTPVKITLTEIEPS CCCCCEEEEEEEECC	23.16	23312004
286	Phosphorylation	TPVKITLTEIEPSVE CCCEEEEEEEECCCC	26.68	29978859
291	Phosphorylation	TLTEIEPSVETTTQE EEEEEECCCCCCCCC	21.57	29978859
294	Phosphorylation	EIEPSVETTTQEKTP EEECCCCCCCCCCCC	32.75	29978859
295	Phosphorylation	IEPSVETTTQEKTPE EECCCCCCCCCCCCC	16.99	29978859
296	Phosphorylation	EPSVETTTQEKTPEK ECCCCCCCCCCCCCC	41.99	29978859
300	Phosphorylation	ETTTQEKTPEKQDIC CCCCCCCCCCCCCCC	35.61	29743597
311	Phosphorylation	QDICLKPSPDTVPTV CCCCCCCCCCCCCEE	33.54	27486199
314	Phosphorylation	CLKPSPDTVPTVTVS CCCCCCCCCCEEEEC	31.59	27486199
317	Phosphorylation	PSPDTVPTVTVSEPE CCCCCCCEEEECCCC	25.19	28270605
319	Phosphorylation	PDTVPTVTVSEPEDD CCCCCEEEECCCCCC	22.31	28270605
321	Phosphorylation	TVPTVTVSEPEDDSP CCCEEEECCCCCCCC	37.76	28270605
327	Phosphorylation	VSEPEDDSPGSITPP ECCCCCCCCCCCCCC	43.41	28270605
330	Phosphorylation	PEDDSPGSITPPSSG CCCCCCCCCCCCCCC	27.03	28270605
332	Phosphorylation	DDSPGSITPPSSGTE CCCCCCCCCCCCCCC	30.74	28270605
335	Phosphorylation	PGSITPPSSGTEPSA CCCCCCCCCCCCCCH	42.47	28270605
336	Phosphorylation	GSITPPSSGTEPSAA CCCCCCCCCCCCCHH	56.35	28270605
338	Phosphorylation	ITPPSSGTEPSAAES CCCCCCCCCCCHHHH	46.82	27251275
341	Phosphorylation	PSSGTEPSAAESQGK CCCCCCCCHHHHCCC	33.60	27251275
345	Phosphorylation	TEPSAAESQGKGSIS CCCCHHHHCCCCCCC	39.23	28270605
350	Phosphorylation	AESQGKGSISEDELI HHHCCCCCCCHHHHH	26.82	30266825
352	Phosphorylation	SQGKGSISEDELITA HCCCCCCCHHHHHHH	40.47	19664994
358	Phosphorylation	ISEDELITAIKEAKG CCHHHHHHHHHHHCC	34.65	30266825
368	Phosphorylation	KEAKGLSYETAENPR HHHCCCCCCCCCCCC	23.49	22817900
470	Phosphorylation	DSELIIESCDASSAS CCEEHHHHCCCCCCC	13.59	28060719
474	Phosphorylation	IIESCDASSASEESP HHHHCCCCCCCCCCC	17.12	28060719
475	Phosphorylation	IESCDASSASEESPK HHHCCCCCCCCCCCC	37.22	28060719
477	Phosphorylation	SCDASSASEESPKRE HCCCCCCCCCCCCCC	43.79	28060719
480	Phosphorylation	ASSASEESPKREQDS CCCCCCCCCCCCCCC	31.50	28060719
487	Phosphorylation	SPKREQDSPPMKPSA CCCCCCCCCCCCHHH	30.51	30266825
493	Phosphorylation	DSPPMKPSALDAIRE CCCCCCHHHHHHHHH	35.63	23927012
558	Phosphorylation	PRKPEEDSSSNQSPA CCCCCCCCCCCCCCC	38.66	28060719
559	Phosphorylation	RKPEEDSSSNQSPAA CCCCCCCCCCCCCCH	45.70	28060719
560	Phosphorylation	KPEEDSSSNQSPAAT CCCCCCCCCCCCCHH	42.72	28060719
563	Phosphorylation	EDSSSNQSPAATKGP CCCCCCCCCCHHCCC	22.28	28060719
567	Phosphorylation	SNQSPAATKGPGPLG CCCCCCHHCCCCCCC	38.34	28060719
601	Phosphorylation	YWRDIKQTGIVFGSF ECCCHHHHCCHHHHH	24.71	24043423
607	Phosphorylation	QTGIVFGSFLLLLFS HHCCHHHHHHHHHHH	10.97	24043423
614	Phosphorylation	SFLLLLFSLTQFSVV HHHHHHHHCCHHHHH	30.40	24043423
616	Phosphorylation	LLLLFSLTQFSVVSV HHHHHHCCHHHHHHH	26.77	24043423
619	Phosphorylation	LFSLTQFSVVSVVAY HHHCCHHHHHHHHHH	16.28	24043423
622	Phosphorylation	LTQFSVVSVVAYLAL CCHHHHHHHHHHHHH	14.55	24043423
626	Phosphorylation	SVVSVVAYLALAALS HHHHHHHHHHHHHHH	4.86	24043423
633	Phosphorylation	YLALAALSATISFRI HHHHHHHHHHHHHHH	20.74	24043423
635	Phosphorylation	ALAALSATISFRIYK HHHHHHHHHHHHHHH	17.49	24043423
637	Phosphorylation	AALSATISFRIYKSV HHHHHHHHHHHHHHH	12.24	29496963
650	Ubiquitination	SVLQAVQKTDEGHPF HHHHHHHHCCCCCCC	51.88	-
772	Acetylation	QAKIPGAKRHAE--- HHHCCCCHHCCC---	51.11	19668229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RTN1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RTN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RTN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F16A2_HUMAN	FAM160A2	physical	16189514
PKHF2_HUMAN	PLEKHF2	physical	16189514
B2CL1_HUMAN	BCL2L1	physical	11126360
SEY1_YEAST	SEY1	physical	19665976
HDAC8_HUMAN	HDAC8	physical	19140693
SDCB1_HUMAN	SDCBP	physical	25416956
DYRK2_HUMAN	DYRK2	physical	28514442
RTN4_HUMAN	RTN4	physical	28514442
RTN2_HUMAN	RTN2	physical	28514442
PLS1_HUMAN	PLSCR1	physical	28514442
F210B_HUMAN	FAM210B	physical	28514442
MET7A_HUMAN	METTL7A	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
GDN_HUMAN	SERPINE2	physical	28514442
NB5R3_HUMAN	CYB5R3	physical	28514442
TMM43_HUMAN	TMEM43	physical	28514442
TMM70_HUMAN	TMEM70	physical	28514442
SGMR1_HUMAN	SIGMAR1	physical	28514442
CTR3_HUMAN	SLC7A3	physical	28514442
T120B_HUMAN	TMEM120B	physical	28514442
TYSY_HUMAN	TYMS	physical	28514442
PRAF3_HUMAN	ARL6IP5	physical	28514442
DERL2_HUMAN	DERL2	physical	28514442
RASN_HUMAN	NRAS	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RTN1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352 AND SER-487, ANDMASS SPECTROMETRY.	18088087 [Abstract]