GDN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDN_HUMAN
• UniProt AC: P07093
• Protein Name: Glia-derived nexin
• Gene Name: SERPINE2
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Secreted, extracellular space.
• Protein Description: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin..
• Protein Sequence: MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Dimethylation	KQLAMVMRYGVNGVG HHHHHHHHHCCCCHH	17.40	-
82	Methylation	KQLAMVMRYGVNGVG HHHHHHHHHCCCCHH	17.40	58855399
109	Phosphorylation	KKNKDIVTVANAVFV CCCCCCEEEEEEEEE	17.78	29083192
118	N-linked_Glycosylation	ANAVFVKNASEIEVP EEEEEEECCCCCCCC	43.31	UniProtKB CARBOHYD
120	Phosphorylation	AVFVKNASEIEVPFV EEEEECCCCCCCCEE	48.80	29083192
128	Phosphorylation	EIEVPFVTRNKDVFQ CCCCCEEECCCCEEE	28.98	29083192
131	Ubiquitination	VPFVTRNKDVFQCEV CCEEECCCCEEEEEE	52.56	-
159	N-linked_Glycosylation	SINAWVKNETRDMID HHHHHHHHHHHHHHH	46.37	UniProtKB CARBOHYD
170	Phosphorylation	DMIDNLLSPDLIDGV HHHHHHCCHHHHHHH	21.38	-
282	Phosphorylation	KTIDSWMSIMVPKRV CCCCCHHHHHCCCEE	10.98	-
314	Phosphorylation	PLKVLGITDMFDSSK HHHHCCCCCCCCCCC	21.44	20068231
319	Phosphorylation	GITDMFDSSKANFAK CCCCCCCCCCCCEEE	23.60	20068231
320	Phosphorylation	ITDMFDSSKANFAKI CCCCCCCCCCCEEEE	37.32	20068231
359	O-linked_Glycosylation	TKASAATTAILIARS CCCCHHHHHHHHHCC	13.63	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDE_HUMAN	AGL	physical	22863883
NCBP1_HUMAN	NCBP1	physical	22863883
FAM9B_HUMAN	FAM9B	physical	25416956
TPA_HUMAN	PLAT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.