ARL17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL17_HUMAN
• UniProt AC: Q8IVW1
• Protein Name: ADP-ribosylation factor-like protein 17
• Gene Name: ARL17A
• Organism: Homo sapiens (Human).
• Sequence Length: 177
• Subcellular Localization: Golgi apparatus.
• Protein Description: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity)..
• Protein Sequence: MGNIFEKLFKSLLGKKKMRILILSLDTAGKTTILYKLKLGETVPAVPTVGFCVETVEYKNNTFAVWDVGSHFKIRPLWQHFFQNTKGARSPGSTHQGSLASGVLPIKCSHVEFGMWKGGRSHPFLPHSSRCAGSGGQLDSILPHQSPAWGPWGCKDLSSGFPSFLTSSILWKSAVVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNIFEKLF ------CCHHHHHHH	35.62	-
15	Ubiquitination	LFKSLLGKKKMRILI HHHHHHCCCCEEEEE	49.55	-
16	Ubiquitination	FKSLLGKKKMRILIL HHHHHCCCCEEEEEE	50.43	-
35	Phosphorylation	AGKTTILYKLKLGET CCCEEEEEEEECCCC	15.49	-
36	Acetylation	GKTTILYKLKLGETV CCEEEEEEEECCCCC	35.38	30769653
36	Ubiquitination	GKTTILYKLKLGETV CCEEEEEEEECCCCC	35.38	-
90	Phosphorylation	QNTKGARSPGSTHQG HCCCCCCCCCCCCCC	32.83	-
93	Phosphorylation	KGARSPGSTHQGSLA CCCCCCCCCCCCCCC	26.54	-
94	Phosphorylation	GARSPGSTHQGSLAS CCCCCCCCCCCCCCC	24.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ARL17_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36, AND MASS SPECTROMETRY.
PubMed: 19608861