SPPL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPPL3_HUMAN
• UniProt AC: Q8TCT6
• Protein Name: Signal peptide peptidase-like 3 {ECO:0000303|PubMed:12077416, ECO:0000312|HGNC:HGNC:30424}
• Gene Name: SPPL3 {ECO:0000303|PubMed:12077416, ECO:0000312|HGNC:HGNC:30424}
• Organism: Homo sapiens (Human).
• Sequence Length: 384
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus . Membrane ; Multi-pass membrane protein ; Lumenal side .
• Protein Description: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. [PubMed: 16873890]
• Protein Sequence: MAEQTYSWAYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSNSSSGSFNGNSTNNSIQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQNKISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLLLSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPNVGRDVPRLSLPGKLVFPSSTGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
141	Phosphorylation	GCCGRFTAAELLSFS CCCCCCCHHHHHHHH	24.48	29083192
147	Phosphorylation	TAAELLSFSLSVMLV CHHHHHHHHHHHHHH	25.97	29083192
149	Phosphorylation	AELLSFSLSVMLVLI HHHHHHHHHHHHHHH	19.16	29083192
151	Phosphorylation	LLSFSLSVMLVLIWV HHHHHHHHHHHHHHH	12.32	29083192
186	Phosphorylation	AFVRLPSLKVSCLLL HHHHCCHHHHHHHHH	45.47	24719451
221	O-linked_Glycosylation	NVMVKVATQPADNPL CEEEEEECCCCCCHH	8.52	OGP
235	Ubiquitination	LDVLSRKLHLGPNVG HHHHHHHHCCCCCCC	36.56	-
290	Ubiquitination	LRYDNYKKQASGDSC HHCCCCCHHCCCCCC	44.67	-
291	Ubiquitination	RYDNYKKQASGDSCG HCCCCCHHCCCCCCC	40.51	-
370	Phosphorylation	DLRRMWSEPFHSKSS HHHHHHCCCCCCCCC	26.50	30576142
376	Ubiquitination	SEPFHSKSSSSRFLE CCCCCCCCCCCCCCC	45.87	-
379	Phosphorylation	FHSKSSSSRFLEV-- CCCCCCCCCCCCC--	32.40	30576142
380	Phosphorylation	HSKSSSSRFLEV--- CCCCCCCCCCCC---	29.06	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPPL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPPL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPPL3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPPL3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.