GSLG1_HUMAN - dbPTM
GSLG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GSLG1_HUMAN
UniProt AC Q92896
Protein Name Golgi apparatus protein 1
Gene Name GLG1
Organism Homo sapiens (Human).
Sequence Length 1179
Subcellular Localization Golgi apparatus membrane
Single-pass type I membrane protein .
Protein Description Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils)..
Protein Sequence MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQPPFPAGGPPARRGGAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLVVECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVSLKCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEAAAQEQTGQVEECLKVNLLKIKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSVISGSICILFLIGLMCGRITKRVTRELKDR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37O-linked_GlycosylationLPGQGVHSQGQGPGA
CCCCCCCCCCCCCCC		33.33OGP
69O-linked_GlycosylationQLPQLPQSSQLQQQQ
CCCCCCCHHHHHHHH		20.36OGP
70O-linked_GlycosylationLPQLPQSSQLQQQQQ
CCCCCCHHHHHHHHH		29.66OGP
117PhosphorylationWKLAEEESCREDVTR
CHHCCHHHHHCCHHH		23.04-
123PhosphorylationESCREDVTRVCPKHT
HHHHCCHHHHCCCCC		29.7023532336
165N-linked_GlycosylationLLWNYKLNLTTDPKF
HHHHCCCCCCCCHHH		31.05UniProtKB CARBOHYD
188AcetylationKSTITEIKECADEPV
HHHHHHHHHHCCCCC		40.2726051181
210N-linked_GlycosylationCLVDHRGNITEYQCH
EEECCCCCCCHHHHH		37.66UniProtKB CARBOHYD
238UbiquitinationYRLICGFMDDCKNDI
HHHHHCCCHHHCCCC		2.2929967540
242AcetylationCGFMDDCKNDINILK
HCCCHHHCCCCCEEE		65.7326051181
249UbiquitinationKNDINILKCGSIRLG
CCCCCEEECCCEECC		32.5229967540
258AcetylationGSIRLGEKDAHSQGE
CCEECCCCCCCCCCC		59.4226051181
261UbiquitinationRLGEKDAHSQGEVVS
ECCCCCCCCCCCHHH		30.6829967540
272UbiquitinationEVVSCLEKGLVKEAE
CHHHHHHHCCHHHHH		44.5929967540
272AcetylationEVVSCLEKGLVKEAE
CHHHHHHHCCHHHHH		44.5926051181
310MethylationSDDFHLDRHLYFACR
CCCCCCCHHHHEEEC		28.24-
349UbiquitinationKFEESMSEKCREALT
CCHHHHCHHHHHHHH		47.7529967540
360UbiquitinationEALTTRQKLIAQDYK
HHHHHHHHHHHCHHH		38.2729967540
370PhosphorylationAQDYKVSYSLAKSCK
HCHHHHHHHHHHHCH		15.64-
374 (in isoform 2)Ubiquitination-62.77-
374UbiquitinationKVSYSLAKSCKSDLK
HHHHHHHHHCHHHHH		62.77-
374AcetylationKVSYSLAKSCKSDLK
HHHHHHHHHCHHHHH		62.7726051181
383PhosphorylationCKSDLKKYRCNVENL
CHHHHHHHCCCHHCC		20.8624927040
416PhosphorylationVHRGRQVSSECQGEM
HHHCCCCCHHHCHHH		16.4523663014
417PhosphorylationHRGRQVSSECQGEML
HHCCCCCHHHCHHHH		43.4623663014
426PhosphorylationCQGEMLDYRRMLMED
HCHHHHHHHHHHHHC		8.9923663014
460MethylationSGLHRKGRTLHCLMK
CCCCCCCCHHHHHHH		36.83-
460DimethylationSGLHRKGRTLHCLMK
CCCCCCCCHHHHHHH		36.83-
467AcetylationRTLHCLMKVVRGEKG
CHHHHHHHHHHCCCC		25.3226051181
486O-linked_GlycosylationNCQQALQTLIQETDP
CHHHHHHHHHHHCCC		27.03OGP
491O-linked_GlycosylationLQTLIQETDPGADYR
HHHHHHHCCCCCCHH		30.99OGP
516 (in isoform 2)Ubiquitination-39.33-
516UbiquitinationSVIQTACKHIRSGDP
HHHHHHHHHHHCCCH		39.33-
551PhosphorylationHRLLELQYFISRDWK
HHHHHHHHHHHCCCC		18.59-
558 (in isoform 2)Ubiquitination-47.50-
558UbiquitinationYFISRDWKLDPVLYR
HHHHCCCCCCHHHHH		47.50-
564PhosphorylationWKLDPVLYRKCQGDA
CCCCHHHHHHCCCCH		14.3021406692
581N-linked_GlycosylationLCHTHGWNETSEFMP
HCCCCCCCCCCCCCC		47.46UniProtKB CARBOHYD
619UbiquitinationRECRAEVQRILHQRA
HHHHHHHHHHHHHHH		20.4322817900
627UbiquitinationRILHQRAMDVKLDPA
HHHHHHHCCCCCCHH		7.1122817900
630 (in isoform 2)Ubiquitination-42.8021906983
630UbiquitinationHQRAMDVKLDPALQD
HHHHCCCCCCHHHHC		42.8022817900
630 (in isoform 1)Ubiquitination-42.8021906983
638 (in isoform 2)Ubiquitination-20.2721906983
638UbiquitinationLDPALQDKCLIDLGK
CCHHHHCCCEEECCH		20.2722817900
638 (in isoform 1)Ubiquitination-20.2721906983
645UbiquitinationKCLIDLGKWCSEKTE
CCEEECCHHHCCCCC		52.9321906983
677N-linked_GlycosylationECRDIVGNLTELESE
HHHHHHCCCCCCCCC		32.6612754519
714PhosphorylationVADNQIDSGDLMECL
HHCCCCCCCCHHHHH		35.5228192239
739O-linked_GlycosylationEKCAIGVTHFQLVQM
HCCEECCEEEEEEEC		16.2655832601
747AcetylationHFQLVQMKDFRFSYK
EEEEEECCCCCCEEE		36.3090793
786N-linked_GlycosylationCLSTTVRNDTLQEAK
EECCCCCCCHHHHHH		42.13UniProtKB CARBOHYD
812SulfoxidationLRVEELEMTEDIRLE
HHHHHHCCCCCCCCC		8.5421406390
816UbiquitinationELEMTEDIRLEPDLY
HHCCCCCCCCCHHHH		4.3922817900
820UbiquitinationTEDIRLEPDLYEACK
CCCCCCCHHHHHHHH		41.3122817900
827UbiquitinationPDLYEACKSDIKNFC
HHHHHHHHHHHHHHH		59.2022817900
831 (in isoform 1)Ubiquitination-49.3021906983
831UbiquitinationEACKSDIKNFCSAVQ
HHHHHHHHHHHHHHH		49.3022817900
831 (in isoform 2)Ubiquitination-49.3021906983
851UbiquitinationIIECLKENKKQLSTR
HHHHHHHCHHHHHHH		56.0629967540
856PhosphorylationKENKKQLSTRCHQKV
HHCHHHHHHHHHHHH		16.0029116813
862UbiquitinationLSTRCHQKVFKLQET
HHHHHHHHHHHHHHH		26.4429967540
905AcetylationKTMLQCLKQNKNSEL
HHHHHHHHHCCCCCC		60.4927452117
922PhosphorylationPKCKQMITKRQITQN
HHHHHHHHHHHHHCC		18.1628555341
927PhosphorylationMITKRQITQNTDYRL
HHHHHHHHCCCCCCC		13.87-
927O-linked_GlycosylationMITKRQITQNTDYRL
HHHHHHHHCCCCCCC		13.87OGP
961PhosphorylationLTKAKDDSELEGQVI
HHCCCCCHHHHHHHH		54.9722617229
981PhosphorylationRYADQRLSSDCEDQI
HHCCHHCCCCCHHHH		26.7329449344
982PhosphorylationYADQRLSSDCEDQIR
HCCHHCCCCCHHHHH		51.3729449344
999PhosphorylationIQESALDYRLDPQLQ
HHHHHCCCCCCCCHH		17.58-
1029UbiquitinationAAQEQTGQVEECLKV
HHHHHCCCHHHHHHH		42.7232142685
1040UbiquitinationCLKVNLLKIKTELCK
HHHHCHHHHCHHHHH		45.3732142685
1042AcetylationKVNLLKIKTELCKKE
HHCHHHHCHHHHHHH		34.0727452117
1091PhosphorylationPGRGRQMSCLMEALE
CCCCHHHHHHHHHHH		8.8520068231
1120O-linked_GlycosylationNDRIEMWSYAAKVAP
HHHHHHHHHHHHCCC		12.00OGP
1179UbiquitinationVTRELKDR-------
HHHHHHCC-------		47.0222817900
1184 (in isoform 3)Phosphorylation-29052541
1188 (in isoform 3)Phosphorylation-30266825
1190 (in isoform 3)Phosphorylation-30266825
1190 (in isoform 2)Ubiquitination-21906983
1190Ubiquitination------------------
------------------		22817900
1195 (in isoform 2)Phosphorylation-29052541
1199 (in isoform 2)Phosphorylation-30266825
1201 (in isoform 2)Phosphorylation-30266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GSLG1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GSLG1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GSLG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LYAM2_HUMANSELEphysical
11404363
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GSLG1_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry.";
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
Nat. Biotechnol. 21:660-666(2003).
Cited for: GLYCOSYLATION AT ASN-677.

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