| UniProt ID | LYAM2_HUMAN | |
|---|---|---|
| UniProt AC | P16581 | |
| Protein Name | E-selectin | |
| Gene Name | SELE | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 610 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.. | |
| Protein Sequence | MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | KESGAWSYNTSTEAM HHCCCCCCCCCCCEE | 16.26 | - | |
| 25 | N-linked_Glycosylation | ESGAWSYNTSTEAMT HCCCCCCCCCCCEEC | 23.26 | 26117840 | |
| 32 | Phosphorylation | NTSTEAMTYDEASAY CCCCCEECHHHHHHH | 34.56 | 22210691 | |
| 37 | Phosphorylation | AMTYDEASAYCQQRY EECHHHHHHHHHHHC | 20.09 | 22210691 | |
| 39 | Phosphorylation | TYDEASAYCQQRYTH CHHHHHHHHHHHCCE | 6.57 | 22210691 | |
| 66 | Phosphorylation | LNSILSYSPSYYWIG HHHHHHCCCCEEEEE | 12.18 | 26503514 | |
| 68 | Phosphorylation | SILSYSPSYYWIGIR HHHHCCCCEEEEEEE | 25.55 | 26503514 | |
| 69 | Phosphorylation | ILSYSPSYYWIGIRK HHHCCCCEEEEEEEE | 13.25 | 26503514 | |
| 70 | Phosphorylation | LSYSPSYYWIGIRKV HHCCCCEEEEEEEEE | 8.55 | 26503514 | |
| 76 | Ubiquitination | YYWIGIRKVNNVWVW EEEEEEEEECCEEEE | 47.60 | 29967540 | |
| 117 | Ubiquitination | DCVEIYIKREKDVGM CCEEEEEEEHHCCCC | 37.22 | - | |
| 145 | N-linked_Glycosylation | CYTAACTNTSCSGHG EEEHHCCCCCCCCCC | 29.85 | 26117840 | |
| 160 | N-linked_Glycosylation | ECVETINNYTCKCDP HHEEEECCEECCCCC | 29.64 | 26117840 | |
| 170 | Phosphorylation | CKCDPGFSGLKCEQI CCCCCCCCCCCEEEE | 49.48 | 22985185 | |
| 179 | N-linked_Glycosylation | LKCEQIVNCTALESP CCEEEEEECEECCCC | 21.03 | 26117840 | |
| 199 | N-linked_Glycosylation | VCSHPLGNFSYNSSC EEECCCCCCCCCCCC | 30.30 | 26117840 | |
| 203 | N-linked_Glycosylation | PLGNFSYNSSCSISC CCCCCCCCCCCEEEE | 26.67 | 26117840 | |
| 265 | N-linked_Glycosylation | NPGSFPWNTTCTFDC CCCCCCCCCEEEEEC | 26.25 | 26117840 | |
| 312 | N-linked_Glycosylation | RAVRQPQNGSVRCSH EEECCCCCCCEEECC | 51.93 | UniProtKB CARBOHYD | |
| 318 | Phosphorylation | QNGSVRCSHSPAGEF CCCCEEECCCCCCEE | 19.21 | - | |
| 332 | N-linked_Glycosylation | FTFKSSCNFTCEEGF EEEEECCCCEECCCE | 36.89 | UniProtKB CARBOHYD | |
| 383 | Phosphorylation | GYMNCLPSASGSFRY CCCCCCCCCCCCCCC | 23.32 | 22964224 | |
| 385 | Phosphorylation | MNCLPSASGSFRYGS CCCCCCCCCCCCCCC | 39.03 | 22964224 | |
| 387 | Phosphorylation | CLPSASGSFRYGSSC CCCCCCCCCCCCCCC | 12.21 | 22964224 | |
| 390 | Phosphorylation | SASGSFRYGSSCEFS CCCCCCCCCCCCEEE | 21.24 | - | |
| 452 | Phosphorylation | HSPIGEFTYKSSCAF CCCCCEEEEECCCEE | 26.24 | 24719451 | |
| 453 | Phosphorylation | SPIGEFTYKSSCAFS CCCCEEEEECCCEEE | 17.75 | 24719451 | |
| 503 | N-linked_Glycosylation | LAVPGKINMSCSGEP CCCCCEEEECCCCCC | 21.57 | UniProtKB CARBOHYD | |
| 527 | N-linked_Glycosylation | CPEGWTLNGSAARTC CCCCEEECCHHHHHC | 34.69 | UniProtKB CARBOHYD | |
| 603 | Phosphorylation | SLESDGSYQKPSYIL CCCCCCCCCCCCCCC | 26.53 | 11602579 | |
| 603 | Dephosphorylation | SLESDGSYQKPSYIL CCCCCCCCCCCCCCC | 26.53 | 11602579 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LYAM2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LYAM2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LYAM2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FAK1_HUMAN | PTK2 | physical | 8609175 | |
| PAXI_HUMAN | PXN | physical | 8609175 | |
| ACTA_HUMAN | ACTA2 | physical | 8609175 | |
| VINC_HUMAN | VCL | physical | 8609175 | |
| FLNA_HUMAN | FLNA | physical | 8609175 | |
| DIP2B_HUMAN | DIP2B | physical | 28514442 | |
| DIP2A_HUMAN | DIP2A | physical | 28514442 | |
| MBLC2_HUMAN | MBLAC2 | physical | 28514442 | |
| MTMR1_HUMAN | MTMR1 | physical | 28514442 | |
| MTMR5_HUMAN | SBF1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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