dbPTM

DIP2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DIP2B_HUMAN
UniProt AC	Q9P265
Protein Name	Disco-interacting protein 2 homolog B
Gene Name	DIP2B
Organism	Homo sapiens (Human).
Sequence Length	1576
Subcellular Localization
Protein Description
Protein Sequence	MAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYSPQTQETDSAVQKELRNQTPAPSAAQTSAPSKYHRTRSGGARDERYRSDIHTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENFSAPPDVTTTTSSSSSSSSIRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVSSRVSTKIQQLLNTLKRPKRPPLKEFFVDDSEEIVEVPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGTTQAKCSCLTALDMTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGETIVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVNSAGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTSQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLDPIYVAYNM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AERGLEPSPAAVAAL CCCCCCCCHHHHHCC	20.14	29255136
32	Phosphorylation	AELELELSEGDITQK HHHEEECCCCCCCCC	30.11	-
37	Phosphorylation	ELSEGDITQKGYEKK ECCCCCCCCCCHHHH	29.03	-
46	Phosphorylation	KGYEKKRSKLLSPYS CCHHHHHHHCCCCCC	36.21	23312004
47	Ubiquitination	GYEKKRSKLLSPYSP CHHHHHHHCCCCCCC	58.44	21890473
47 (in isoform 1)	Ubiquitination	-	58.44	21890473
50	Phosphorylation	KKRSKLLSPYSPQTQ HHHHHCCCCCCCCCH	32.03	25159151
52	Phosphorylation	RSKLLSPYSPQTQET HHHCCCCCCCCCHHC	29.61	25159151
53	Phosphorylation	SKLLSPYSPQTQETD HHCCCCCCCCCHHCC	17.57	25159151
56	Phosphorylation	LSPYSPQTQETDSAV CCCCCCCCHHCCHHH	31.58	21712546
59	Phosphorylation	YSPQTQETDSAVQKE CCCCCHHCCHHHHHH	25.99	24732914
61	Phosphorylation	PQTQETDSAVQKELR CCCHHCCHHHHHHHH	37.45	24732914
65	Ubiquitination	ETDSAVQKELRNQTP HCCHHHHHHHHHCCC	52.71	21890473
65 (in isoform 1)	Ubiquitination	-	52.71	21890473
71	Phosphorylation	QKELRNQTPAPSAAQ HHHHHHCCCCCCHHH	25.60	29255136
75	Phosphorylation	RNQTPAPSAAQTSAP HHCCCCCCHHHCCCC	38.04	29255136
79	Phosphorylation	PAPSAAQTSAPSKYH CCCCHHHCCCCCCCC	23.33	29255136
80	Phosphorylation	APSAAQTSAPSKYHR CCCHHHCCCCCCCCC	26.54	29255136
83	Phosphorylation	AAQTSAPSKYHRTRS HHHCCCCCCCCCCCC	45.63	29255136
84	Acetylation	AQTSAPSKYHRTRSG HHCCCCCCCCCCCCC	43.97	25953088
84	Ubiquitination	AQTSAPSKYHRTRSG HHCCCCCCCCCCCCC	43.97	-
85	Phosphorylation	QTSAPSKYHRTRSGG HCCCCCCCCCCCCCC	10.81	30576142
88	Phosphorylation	APSKYHRTRSGGARD CCCCCCCCCCCCCCC	18.84	30576142
90	Phosphorylation	SKYHRTRSGGARDER CCCCCCCCCCCCCHH	40.75	30576142
98	Phosphorylation	GGARDERYRSDIHTE CCCCCHHHHHHHHHH	16.66	30266825
100	Phosphorylation	ARDERYRSDIHTEAV CCCHHHHHHHHHHHH	31.79	29255136
104	Phosphorylation	RYRSDIHTEAVQAAL HHHHHHHHHHHHHHH	26.44	30266825
113	Ubiquitination	AVQAALAKHKEQKMA HHHHHHHHCHHHHCC	56.94	-
115	Ubiquitination	QAALAKHKEQKMALP HHHHHHCHHHHCCCC	62.22	-
125	Phosphorylation	KMALPMPTKRRSTFV HCCCCCCCCCCCCCC	30.82	29514088
126	Acetylation	MALPMPTKRRSTFVQ CCCCCCCCCCCCCCC	39.69	25953088
126	Ubiquitination	MALPMPTKRRSTFVQ CCCCCCCCCCCCCCC	39.69	-
129	Phosphorylation	PMPTKRRSTFVQSPA CCCCCCCCCCCCCHH	30.17	28450419
130	Phosphorylation	MPTKRRSTFVQSPAD CCCCCCCCCCCCHHH	26.47	28450419
134	Phosphorylation	RRSTFVQSPADACTP CCCCCCCCHHHHCCC	19.43	23663014
140	Phosphorylation	QSPADACTPPDTSSA CCHHHHCCCCCCCCC	39.31	21712546
144	Phosphorylation	DACTPPDTSSASEDE HHCCCCCCCCCCCCC	30.29	23401153
145	Phosphorylation	ACTPPDTSSASEDEG HCCCCCCCCCCCCCC	31.15	21082442
146	Phosphorylation	CTPPDTSSASEDEGS CCCCCCCCCCCCCCH	37.60	21712546
148	Phosphorylation	PPDTSSASEDEGSLR CCCCCCCCCCCCHHH	47.75	22617229
153	Phosphorylation	SASEDEGSLRRQAAL CCCCCCCHHHHHHHH	19.36	22617229
167	Phosphorylation	LSAALQQSLQNAESW HHHHHHHHHHHHHHH	20.97	27470641
173	Phosphorylation	QSLQNAESWINRSIQ HHHHHHHHHHHHHHC	30.74	27470641
178	Phosphorylation	AESWINRSIQGSSTS HHHHHHHHHCCCCCC	18.12	28450419
182	Phosphorylation	INRSIQGSSTSSSAS HHHHHCCCCCCCCCC	17.67	28450419
183	Phosphorylation	NRSIQGSSTSSSASS HHHHCCCCCCCCCCC	38.85	28450419
184	Phosphorylation	RSIQGSSTSSSASST HHHCCCCCCCCCCCC	34.03	28450419
185	Phosphorylation	SIQGSSTSSSASSTL HHCCCCCCCCCCCCC	25.01	23927012
186	Phosphorylation	IQGSSTSSSASSTLS HCCCCCCCCCCCCCC	29.97	28450419
187	Phosphorylation	QGSSTSSSASSTLSH CCCCCCCCCCCCCCC	31.75	23927012
189	Phosphorylation	SSTSSSASSTLSHGE CCCCCCCCCCCCCCE	26.29	28450419
190	Phosphorylation	STSSSASSTLSHGEV CCCCCCCCCCCCCEE	32.84	28450419
191	Phosphorylation	TSSSASSTLSHGEVK CCCCCCCCCCCCEEC	29.77	28450419
193	Phosphorylation	SSASSTLSHGEVKGT CCCCCCCCCCEECCC	29.54	28450419
198	Ubiquitination	TLSHGEVKGTSGSLA CCCCCEECCCCCCHH	52.77	-
200	Phosphorylation	SHGEVKGTSGSLADV CCCEECCCCCCHHHH	24.97	29255136
201	Phosphorylation	HGEVKGTSGSLADVF CCEECCCCCCHHHHH	34.74	29255136
203	Phosphorylation	EVKGTSGSLADVFAN EECCCCCCHHHHHHC	21.83	29255136
211	Phosphorylation	LADVFANTRIENFSA HHHHHHCCCEECCCC	29.60	23403867
223	Phosphorylation	FSAPPDVTTTTSSSS CCCCCCCEECCCCCC	26.30	22210691
227	Phosphorylation	PDVTTTTSSSSSSSS CCCEECCCCCCCCCC	26.57	22210691
231	Phosphorylation	TTTSSSSSSSSIRPA ECCCCCCCCCCCCCC	35.87	27470641
232	Phosphorylation	TTSSSSSSSSIRPAN CCCCCCCCCCCCCCC	30.01	22210691
255	Phosphorylation	VKGMHKGSNRSSLMD CCCCCCCCCCCCCCC	33.60	23927012
258	Phosphorylation	MHKGSNRSSLMDTAD CCCCCCCCCCCCCCC	31.88	23401153
259	Phosphorylation	HKGSNRSSLMDTADG CCCCCCCCCCCCCCC	25.19	23927012
263	Phosphorylation	NRSSLMDTADGVPVS CCCCCCCCCCCCCCH	16.81	23927012
270	Phosphorylation	TADGVPVSSRVSTKI CCCCCCCHHHHHHHH	13.32	23403867
271	Phosphorylation	ADGVPVSSRVSTKIQ CCCCCCHHHHHHHHH	36.61	28348404
274	Phosphorylation	VPVSSRVSTKIQQLL CCCHHHHHHHHHHHH	23.91	28348404
275	Phosphorylation	PVSSRVSTKIQQLLN CCHHHHHHHHHHHHH	29.34	28348404
276	Ubiquitination	VSSRVSTKIQQLLNT CHHHHHHHHHHHHHH	30.89	21890473
276 (in isoform 1)	Ubiquitination	-	30.89	21890473
283	Phosphorylation	KIQQLLNTLKRPKRP HHHHHHHHCCCCCCC	33.36	23401153
285	Ubiquitination	QQLLNTLKRPKRPPL HHHHHHCCCCCCCCC	65.69	-
285 (in isoform 1)	Ubiquitination	-	65.69	21890473
288	Ubiquitination	LNTLKRPKRPPLKEF HHHCCCCCCCCCHHC	79.96	-
293	Ubiquitination	RPKRPPLKEFFVDDS CCCCCCCHHCCCCCC	59.24	21906983
293 (in isoform 1)	Ubiquitination	-	59.24	21890473
315	Ubiquitination	QPDPNQPKPEGRQMT CCCCCCCCCCCCCCC	46.03	-
322	Phosphorylation	KPEGRQMTPVKGEPL CCCCCCCCCCCCCEE	19.32	24719451
383	Phosphorylation	SRSLKLAYTLLNKLG HHHHHHHHHHHHHHC	14.35	-
384	Phosphorylation	RSLKLAYTLLNKLGT HHHHHHHHHHHHHCC	21.11	-
391	Phosphorylation	TLLNKLGTKNEPVLK HHHHHHCCCCCCCCC	40.93	-
480	Ubiquitination	NGEIVQFKGWPRLKW CCCEEEECCCCCEEE	42.87	21890473
480 (in isoform 1)	Ubiquitination	-	42.87	21890473
492	O-linked_Glycosylation	LKWVVTDSKYLSKPP EEEEEECHHHCCCCC	17.52	30379171
494	Phosphorylation	WVVTDSKYLSKPPKD EEEECHHHCCCCCCC	21.84	23403867
496	Phosphorylation	VTDSKYLSKPPKDWQ EECHHHCCCCCCCCC	39.77	23403867
519	Ubiquitination	EPAYIEYKTSKEGSV CCEEEEEECCCCCCC	33.27	-
525	Phosphorylation	YKTSKEGSVMGVTVS EECCCCCCCEEEEHH	15.26	17192257
530	Phosphorylation	EGSVMGVTVSRLAML CCCCEEEEHHHHHHH	13.66	-
532	Phosphorylation	SVMGVTVSRLAMLSH CCEEEEHHHHHHHHH	16.53	24719451
554	Phosphorylation	CNYSEGETIVNVLDF CCCCCCCEEEEEEEE	40.87	22210691
578	Ubiquitination	MFANVMNKMHTISVP HHHHHHHHCCCCCCC	17.60	-
611	Ubiquitination	KAKVALVKCRDLHWA CCEEEEEEHHHHHHH	25.13	-
629	Phosphorylation	HRDQRDVSLSSLRML CCCCCCCCHHHEEEE	27.16	22167270
631	Phosphorylation	DQRDVSLSSLRMLIV CCCCCCHHHEEEEEE	21.59	22167270
632	Phosphorylation	QRDVSLSSLRMLIVT CCCCCHHHEEEEEEC	25.86	22167270
714	Ubiquitination	IRVNTEDKNSALTVQ EEEECCCCCCCEEEE	46.71	-
719	Phosphorylation	EDKNSALTVQDVGHV CCCCCCEEEEECCCC	18.81	24719451
746	Phosphorylation	GPPQLCKTDEIGEIC CCCCCCCCCCCCCEE	37.56	-
755	Phosphorylation	EIGEICVSSRTGGMM CCCCEEEECCCCCEE	15.08	-
756	Phosphorylation	IGEICVSSRTGGMMY CCCEEEECCCCCEEE	17.29	-
781	Phosphorylation	FEVIPVNSAGSPVGD EEEEECCCCCCCCCC	33.95	28348404
784	Phosphorylation	IPVNSAGSPVGDVPF EECCCCCCCCCCCCC	19.01	28348404
794	Phosphorylation	GDVPFIRSGLLGFVG CCCCCCCCCCCCEEC	29.04	25867546
804	Phosphorylation	LGFVGPGSLVFVVGK CCEECCCCEEEEEEE	25.21	25867546
819	Phosphorylation	MDGLLMVSGRRHNAD CCCEEEEECCCCCHH	16.77	25867546
831	Phosphorylation	NADDIVATGLAVESI CHHHHHHCCCHHHHH	23.10	-
837	Phosphorylation	ATGLAVESIKTVYRG HCCCHHHHHHHHCCC	23.84	-
887	Phosphorylation	RVLQAIDSIHQVGVY HHHHHHHHHHHHCCE	18.83	-
894	Phosphorylation	SIHQVGVYCLALVPA HHHHHCCEEEEEEEC	3.94	-
903	Phosphorylation	LALVPANTLPKTPLG EEEEECCCCCCCCCC	46.69	-
907	Phosphorylation	PANTLPKTPLGGIHI ECCCCCCCCCCCEEE	23.08	-
956	Phosphorylation	QPGVGPASVMVGNLV CCCCCCHHHHCCHHH	17.55	27470641
1035	Phosphorylation	KRAERIASVLGDKGH HHHHHHHHHHCCCCC	18.59	-
1125	Ubiquitination	AAAAVDVKTWPTIID HHHCCCCCCCCCEEC	40.17	21906983
1125 (in isoform 1)	Ubiquitination	-	40.17	21890473
1149	Phosphorylation	PQLYKPPTPEMLAYL CCCCCCCCHHHHHCC	40.17	-
1155	Phosphorylation	PTPEMLAYLDFSVST CCHHHHHCCCEEEEC	11.66	-
1297	Phosphorylation	PRVALQQSFSKLFKD HHHHHHHHHHHHHHH	20.66	24719451
1300	Ubiquitination	ALQQSFSKLFKDIGL HHHHHHHHHHHHHCC	56.80	21890473
1300 (in isoform 1)	Ubiquitination	-	56.80	21890473
1303	Ubiquitination	QSFSKLFKDIGLSPR HHHHHHHHHHCCCCC	59.89	-
1308	Phosphorylation	LFKDIGLSPRAVSTT HHHHHCCCCCEECCC	13.71	24719451
1359	Phosphorylation	VERGAPQSLLLSESG HHCCCCCCEEECCCC	21.67	20068231
1363	Phosphorylation	APQSLLLSESGKILP CCCCEEECCCCCCCC	29.68	20068231
1365	Phosphorylation	QSLLLSESGKILPGV CCEEECCCCCCCCCC	41.85	20068231
1367	Ubiquitination	LLLSESGKILPGVKV EEECCCCCCCCCCEE	50.80	2189047
1367 (in isoform 1)	Ubiquitination	-	50.80	21890473
1404	Phosphorylation	SPHTASGYYTIYDSE CCCCCCEEEEEEECC	8.57	-
1430	Phosphorylation	SFGDAAQTLWARTGY CHHHHHHHHHHHHCC	21.38	25850435
1437	Phosphorylation	TLWARTGYLGFVRRT HHHHHHCCCCEEEEE	11.75	-
1458	Phosphorylation	GERHDALYVVGALDE CCCCEEEEEEECCCC	8.53	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DIP2B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DIP2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DIP2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DIP2B_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DIP2B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-50; SER-53;THR-71; SER-100; THR-140; SER-145; SER-146 AND SER-148, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-153, ANDMASS SPECTROMETRY.	15302935 [Abstract]