TUSC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TUSC3_HUMAN
• UniProt AC: Q13454
• Protein Name: Tumor suppressor candidate 3
• Gene Name: TUSC3
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.; Magnesium transporter..
• Protein Sequence: MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSDLDFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Dimethylation	LMEWSSRRSIFRMNG HHHHHHHHHHHHHCH	35.73	-
63	Methylation	LMEWSSRRSIFRMNG HHHHHHHHHHHHHCH	35.73	58855423
67	Dimethylation	SSRRSIFRMNGDKFR HHHHHHHHHCHHHHH	18.91	-
67	Methylation	SSRRSIFRMNGDKFR HHHHHHHHHCHHHHH	18.91	58855429
72	Acetylation	IFRMNGDKFRKFIKA HHHHCHHHHHHHHCC	48.76	27452117
109	Phosphorylation	CRQANEEYQILANSW HHHHCHHHHHHHHHH	8.48	24043423
115	Phosphorylation	EYQILANSWRYSSAF HHHHHHHHHHHCHHH	13.81	24043423
124	Ubiquitination	RYSSAFCNKLFFSMV HHCHHHHHHHHHHCC	37.30	21987572
180	Ubiquitination	FAAEQLAKWIADRTD HHHHHHHHHHHHCCC	47.96	21987572
180 (in isoform 2)	Ubiquitination	-	47.96	20972266
216	Phosphorylation	SLVGGLLYLRRNNLE HHHHHHHHHHHCCCC	11.82	-
281	Phosphorylation	QAQFVAESHIILVLN HHHHHHHHHHHHHHH	15.39	-
292	Phosphorylation	LVLNAAITMGMVLLN HHHHHHHHHHHHHHH	11.71	-
327	Phosphorylation	GLVVFFFSFLLSIFR HHHHHHHHHHHHHHH	15.16	19276368
331	Phosphorylation	FFFSFLLSIFRSKYH HHHHHHHHHHHHHHC	23.10	19276368

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TUSC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TUSC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TUSC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPN2_HUMAN	RPN2	physical	28514442
F122B_HUMAN	FAM122B	physical	28514442
STXB2_HUMAN	STXBP2	physical	28514442
LIN54_HUMAN	LIN54	physical	28514442
STXB1_HUMAN	STXBP1	physical	28514442
NDRG3_HUMAN	NDRG3	physical	28514442
GGT7_HUMAN	GGT7	physical	28514442
NHRF2_HUMAN	SLC9A3R2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00768: Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
• OMIM Disease
• 611093: Mental retardation, autosomal recessive 7 (MRT7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.