| UniProt ID | FZD2_HUMAN | |
|---|---|---|
| UniProt AC | Q14332 | |
| Protein Name | Frizzled-2 | |
| Gene Name | FZD2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 565 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.. | |
| Protein Sequence | MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MRPRSALPRLLL ---CCCHHHHHHHHH | 36.52 | 24719451 | |
| 32 | O-linked_Glycosylation | FHGEKGISIPDHGFC HCCCCCCCCCCCCCC | 36.42 | 55825697 | |
| 53 | N-linked_Glycosylation | LCTDIAYNQTIMPNL EECHHCCCCCCCHHH | 24.40 | 29748286 | |
| 112 | Phosphorylation | QAIPPCRSICERARQ HHCHHHHHHHHHHHH | 38.00 | 28634120 | |
| 127 | Ubiquitination | GCEALMNKFGFQWPE HHHHHHHHHCCCCCH | 32.66 | - | |
| 154 | N-linked_Glycosylation | EQICVGQNHSEDGAP CEEECCCCCCCCCCC | 34.42 | UniProtKB CARBOHYD | |
| 165 | O-linked_Glycosylation | DGAPALLTTAPPPGL CCCCCEEECCCCCCC | 23.05 | 55827455 | |
| 166 | O-linked_Glycosylation | GAPALLTTAPPPGLQ CCCCEEECCCCCCCC | 36.82 | 55827461 | |
| 179 | O-linked_Glycosylation | LQPGAGGTPGGPGGG CCCCCCCCCCCCCCC | 20.17 | 55827467 | |
| 194 | O-linked_Glycosylation | GAPPRYATLEHPFHC CCCCCCCCCCCCCCC | 24.60 | 55830743 | |
| 206 | Ubiquitination | FHCPRVLKVPSYLSY CCCCCCCCCCCCCCC | 49.60 | - | |
| 210 | Phosphorylation | RVLKVPSYLSYKFLG CCCCCCCCCCCEECC | 8.13 | 24719451 | |
| 212 | Phosphorylation | LKVPSYLSYKFLGER CCCCCCCCCEECCCC | 20.31 | 24719451 | |
| 213 | Phosphorylation | KVPSYLSYKFLGERD CCCCCCCCEECCCCC | 11.81 | 23879269 | |
| 214 | Ubiquitination | VPSYLSYKFLGERDC CCCCCCCEECCCCCC | 30.64 | 21890473 | |
| 284 | Phosphorylation | ERPIIFLSGCYTMVS CCCEEEEECCCHHHH | 18.97 | 22210691 | |
| 287 | Phosphorylation | IIFLSGCYTMVSVAY EEEEECCCHHHHHHH | 11.03 | 22210691 | |
| 288 | Phosphorylation | IFLSGCYTMVSVAYI EEEECCCHHHHHHHH | 18.38 | 22210691 | |
| 291 | Phosphorylation | SGCYTMVSVAYIAGF ECCCHHHHHHHHHHH | 7.10 | 22210691 | |
| 446 | Methylation | FRIRTIMKHDGTKTE HHHHHHHCCCCCCHH | 34.39 | - | |
| 446 | "N6,N6-dimethyllysine" | FRIRTIMKHDGTKTE HHHHHHHCCCCCCHH | 34.39 | - | |
| 500 | Ubiquitination | SWVSQHCKSLAIPCP HHHHHHHHHCCCCCC | 46.51 | - | |
| 510 | Phosphorylation | AIPCPAHYTPRMSPD CCCCCCCCCCCCCCC | 22.12 | 27174698 | |
| 511 | Phosphorylation | IPCPAHYTPRMSPDF CCCCCCCCCCCCCCH | 8.44 | 27174698 | |
| 515 | Phosphorylation | AHYTPRMSPDFTVYM CCCCCCCCCCHHHHH | 23.69 | 27174698 | |
| 519 | Phosphorylation | PRMSPDFTVYMIKYL CCCCCCHHHHHHHHH | 20.36 | 27174698 | |
| 521 | Phosphorylation | MSPDFTVYMIKYLMT CCCCHHHHHHHHHHH | 7.06 | 27174698 | |
| 534 | Phosphorylation | MTLIVGITSGFWIWS HHHHHHHHCCCEECC | 19.50 | - | |
| 541 | Phosphorylation | TSGFWIWSGKTLHSW HCCCEECCCCCHHHH | 22.68 | - | |
| 547 | Phosphorylation | WSGKTLHSWRKFYTR CCCCCHHHHHHHHHH | 31.52 | 24719451 | |
| 552 | Phosphorylation | LHSWRKFYTRLTNSR HHHHHHHHHHHHCCC | 8.25 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FZD2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FZD2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FZD2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| WNT3A_HUMAN | WNT3A | physical | 19910923 | |
| WNT5A_HUMAN | WNT5A | physical | 19910923 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
